Catalog No.
YHJ82701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu832-Leu889
Predicted molecular weight
8.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UP79
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
METH2, ADAM-TS 8, ADAM-TS8, ADAMTS8, METH-8, ADAMTS-8, METH-2, A disintegrin and metalloproteinase with thrombospondin motifs 8
Integrative genome-wide association studies, proteome-wide Mendelian randomization, and single-cell RNA sequencing identify interleukin-6 receptor protein as a therapeutic target in aortic aneurysm., PMID:40409638
DNMT3A facilitates breast cancer progression via regulating ADAMTS8 mediated EGFR-MEK-ERK activation., PMID:40323963
STAT-3, ELK-1, and c- Jun contributes IL-6 mediated ADAMTS-8 upregulation in colorectal cancer., PMID:39969607
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:39809772
The role and mechanism of AMPK in pulmonary hypertension., PMID:39136335
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:38633783
Development of a Novel Biomarker for the Progression of Idiopathic Pulmonary Fibrosis., PMID:38203769
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders., PMID:38182882
Expression and Purification of Recombinant ADAMTS8., PMID:38038931
HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8., PMID:38006215
Establishment of a 6-signature risk model associated with cellular senescence for predicting the prognosis of breast cancer., PMID:37986376
ADAMTS8 inhibits glioma development in vitro and in vivo., PMID:37587889
Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before in vitro fertilization and embryo transfer., PMID:37460099
Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface., PMID:37424113
Novel Implication of the Basement Membrane for Breast Cancer Outcome and Immune Infiltration., PMID:37056938
Expression of ADAMTS 1-4-8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester., PMID:37014320
A novel risk model based on the correlation between the expression of basement membrane genes and immune infiltration to predict the invasiveness of pituitary adenomas., PMID:36686480
The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer., PMID:36346393
Combining bioinformatics, network pharmacology and artificial intelligence to predict the mechanism of celastrol in the treatment of type 2 diabetes., PMID:36339449
Identidication of novel biomarkers in non-small cell lung cancer using machine learning., PMID:36202977
Contribution of MicroRNA-27b-3p to Synovial Fibrotic Responses in Knee Osteoarthritis., PMID:35791923
The Therapeutic Potential of ADAMTS8 in Lung Adenocarcinoma without Targetable Therapy., PMID:35743687
Altered gene expression of selected matrix metalloproteinase system proteins in the broiler chicken gastrointestinal tract during post-hatch development and coccidia infection., PMID:35687960
Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise., PMID:35428952
The Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing., PMID:35250290
ADAMTS8 inhibited lung cancer progression through suppressing VEGFA., PMID:35149432
Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8., PMID:34687701
METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer., PMID:34131102
Expression gradient of metalloproteinases and their inhibitors from proximal to distal segments of abdominal aortic aneurysm., PMID:34091862
Low-intensity pulsed ultrasound promotes aggrecan expression via ZNT-9 in temporomandibular joint chondrocytes., PMID:33227396
ADAMTS8 Inhibits Progression of Esophageal Squamous Cell Carcinoma., PMID:33054388
ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer., PMID:32904790
Transcriptomics Study to Determine the Molecular Mechanism by which sIL-13Rα2-Fc Inhibits Caudal Intervertebral Disc Degeneration in Rats., PMID:32855969
ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor., PMID:32033751
The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer., PMID:31782329
ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target., PMID:31556812
Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide., PMID:31473210
The role of fibroblasts in the pathogenesis of linear morphoea: targeting the secretome., PMID:31025728
The role of ADAMTS genes in the end stage of hip osteoarthritis., PMID:30655094
Downregulation of Extracellular Matrix and Cell Adhesion Molecules in Cumulus Cells of Infertile Polycystic Ovary Syndrome Women with and without Insulin Resistance., PMID:30507086
ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma., PMID:30464505
Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts., PMID:30367460
Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality., PMID:30169632
RNA sequencing reveals target genes of temporomandibular joint osteoarthritis in rats after the treatment of low-intensity pulsed ultrasound., PMID:29885465
Molecular characterization and expression of a disintegrin and metalloproteinase with thrombospondin motifs 8 in chicken., PMID:29879819
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma., PMID:29860265
Proteome response of dental pulp cells to exogenous FGF8., PMID:29758290
Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage., PMID:29137610
Adamts 1, 4, 5, 8, and 9 in Early Pregnancies., PMID:28949770
Differentially regulated ADAMTS1, 8, and 18 in gastric adenocarcinoma., PMID:28814085
For research use only. Not for human or drug use.
