Catalog No.
YHJ81701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys212-Ser448
Predicted molecular weight
28.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UNE0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DL, Ectodermal dysplasia receptor, EDA-A1 receptor, EDAR, Tumor necrosis factor receptor superfamily member EDAR, Ectodysplasin-A receptor, Anhidrotic ectodysplasin receptor 1, Downless homolog
Cost-effective optimisation and validation of the VISAGE enhanced tool assay on the Illumina NovaSeq 6000 platform., PMID:40382887
Molecular Profiling of Odontoclasts during Physiological Tooth Replacement., PMID:39876039
Developmental defects in ectodermal appendages caused by missense mutation in edaradd gene in the nfr mangrove killifish kryptolebias marmoratus., PMID:39837941
PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans., PMID:39672157
Exploring the genetics, mechanisms, and therapeutic innovations in non-syndromic tooth agenesis., PMID:39657464
Evaluation of EDARADD, LPO and ACTN2 genes polymorphisms in children with dental caries compared to caries-free controls., PMID:39543892
Hypohidrotic ectodermal dysplasia caused by an intragenic duplication in EDAR., PMID:39476951
EDA Variants Are Responsible for Approximately 90% of Deciduous Tooth Agenesis., PMID:39408781
Genetic profiling and diagnostic strategies for patients with ectodermal dysplasias in Korea., PMID:39244550
Hydrocortisone treatment as a tool to study conjunctival placode induction., PMID:39096180
Long-Term PM2.5 Exposure and Upregulation of CLCA1 Expression in Nasal Epithelium from Youth with Asthma., PMID:38986136
Novel homozygous frameshift insertion variant in the last exon of the EDARADD causing hypohidrotic ectodermal dysplasia in two siblings: case report and review of the literature., PMID:38840186
ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification., PMID:38582368
Fine Wrinkle Improvement through Bioactive Materials That Modulate EDAR and BNC2 Gene Expression., PMID:38540700
A20: a jack of all trades., PMID:38461099
Transcriptomic and proteomic strategies to reveal the mechanism of Gymnocypris przewalskii scale development., PMID:38310220
Eight EDA mutations in Chinese patients with tooth agenesis and genotype-phenotype analysis., PMID:38287639
The avian ectodermal default competence to make feathers., PMID:38190932
HMZDupFinder: a robust computational approach for detecting intragenic homozygous duplications from exome sequencing data., PMID:38153174
Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum., PMID:38128411
Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis., PMID:38064228
Molecular basis and genetics of hypohidrotic ectodermal dysplasias., PMID:38023809
EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail., PMID:37838280
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte., PMID:37739945
Spatial and Temporal Expression of Ectodysplasin-A Signaling Pathway Members During Mandibular Condylar Development in Postnatal Mice., PMID:37731334
A new variant of the ectodysplasin A receptor death domain gene associated with anhidrotic ectodermal dysplasia in a Turkish family and its simple diagnosis by restriction fragment length polymorphism., PMID:37673591
[Measurement and analysis of the crown conical degree of maxillary incisors in patients with congenital tooth agenesis caused by different gene mutations]., PMID:37550043
X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED): A Case Report and Overview of the Diagnosis and Multidisciplinary Modality Treatments., PMID:37456454
EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes., PMID:37430358
Novel insight into the ectodermal dysplasia 11A: Splicing variant of the EDARADD gene in a family with clinical variability and literature review., PMID:37269152
Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats., PMID:37174489
Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep., PMID:37137429
Comparative Genomic and Transcriptomic Analyses Reveal the Impacts of Genetic Admixture in Kazaks, Uyghurs, and Huis., PMID:36869755
Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis., PMID:36804570
Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants., PMID:36765055
Protocol for the Phase 2 EDELIFE Trial Investigating the Efficacy and Safety of Intra-Amniotic ER004 Administration to Male Subjects with X-Linked Hypohidrotic Ectodermal Dysplasia., PMID:36672894
Divergent tooth development mechanisms of Mexican tetra fish (Astyanax mexicanus) of Pachón cave origin., PMID:36496080
A novel EDAR variant identified in non-syndromic tooth agenesis: Insights from molecular dynamics., PMID:36470092
A novel mutation in the collagen domain of EDA results in hypohidrotic ectodermal dysplasia by impacting the receptor-binding capability., PMID:36448232
Ectodysplasin A1 Deficiency Leads to Osteopetrosis-like Changes in Bones of the Skull Associated with Diminished Osteoclastic Activity., PMID:36293046
Different degree of loss-of-function among four missense mutations in the EDAR gene responsible for autosomal recessive hypohidrotic ectodermal dysplasia may be associated with the phenotypic severity., PMID:36258277
Turing's turtles all the way down: A conserved role of EDAR in the carapacial ridge suggests a deep homology of prepatterns across ectodermal appendages., PMID:36239299
Gene mutations and chromosomal abnormalities in syndromes with tooth agenesis., PMID:36219525
Homeostases of epidermis and hair follicle, and development of basal cell carcinoma., PMID:36089203
WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer., PMID:35999385
Evaluation of facial hair-associated SNPs: a pilot study on male Pakistani Punjabi population., PMID:35994154
Ectodysplasin-A mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response., PMID:35964664
Spatio-temporal dynamics of pathogenic variants associated with monogenic disorders reconstructed with ancient DNA., PMID:35749392
miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network., PMID:35646897
For research use only. Not for human or drug use.
