Catalog No.
YHJ81101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala40-Glu467
Predicted molecular weight
47.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UM47
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
The role of NOTCH3 in CADASIL pathogenesis: insights into novel therapies., PMID:40456481
Case Report: Inflammatory CADASIL phenotype associated with a rare cysteine-sparing NOTCH3 variant., PMID:40438539
Genetic and imaging features of CADASIL patients with acute ischemic stroke., PMID:40379656
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway., PMID:40356960
Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer., PMID:40356021
Induction of T-Cell Differentiation by KLF4 in T-Cell Acute Lymphoblastic Leukemia Cells Harboring Activating Mutation in NOTCH3., PMID:40354086
Vitamin D enhances the effect of Soufeng sanjie formula in alleviating joint inflammation in CIA mice through VDR-NOTCH3/DLL4 signaling in macrophages., PMID:40350051
Signaling pathways and molecular mechanisms involved in the onset and progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); a focus on Notch3 signaling., PMID:40301727
Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort - Implications for NOTCH3 Variant-Specific Disease Prediction., PMID:40265482
ADAMTSL2 is an independent predictor for the prognosis of gastric cancer., PMID:40252157
Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease., PMID:40235495
Inducing mononuclear cells of patients with CADASIL to construct a CSVD disease model., PMID:40176124
Is migraine a common manifestation of CADASIL-Cons., PMID:40170160
Notch3 is an asymmetric gene and a modifier of heart looping defects in Nodal mouse mutants., PMID:40163542
The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease., PMID:40145673
Peripapillary vessel wall changes correlate with disease severity in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)., PMID:40117968
Research and progress of microRNA-136 in metastatic tumors., PMID:40104500
Pre-B-cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in HSC., PMID:40080840
Intracerebral Hemorrhage in Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts and Leukoencephalopathy., PMID:40067051
RANBP1 Regulates NOTCH3-Mediated Autophagy in High Glucose-Induced Vascular Smooth Muscle Cells., PMID:40018934
NOTCH3 Variant Position Affects the Phenotype at the Pluripotent Stem Cell Level in CADASIL., PMID:40016442
ASH2L Deficiency in Smooth Muscle Drives Pulmonary Vascular Remodeling., PMID:39996311
Generation of a human iPSC line with Notch3 R133C mutation by CRISPR/Cas9: A tool for investigating CADASIL and therapeutic targets., PMID:39983483
Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease., PMID:39974976
Synergistic effects of mutation and glycosylation on disease progression., PMID:39967653
Causal association between cerebral small vessel disease and epilepsy., PMID:39954159
Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma., PMID:39951484
Bilateral Middle Cerebellar Peduncle Sign in a Patient with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy and Coronavirus Disease 2019., PMID:39924233
[Treatment-refractory chronic depression in a CADASIL patient with a symptom-free somatic course: a case report]., PMID:39919799
Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease., PMID:39910908
An Innovative Anoikis Signature With Inflammatory Infiltrates in Osteoarthritis., PMID:39895467
Genomic profiles of patients with skin melanoma in the era of immune checkpoint inhibitors., PMID:39888082
Impaired Resting-State Functional Connectivity in Cerebral Autosomal-Dominant Arteriopathy, Subcortical Infarcts, and Leukoencephalopathy Mutant Mice., PMID:39882613
NOTCH1, 2, and 3 receptors enhance osteoblastogenesis of mesenchymal C3H10T1/2 cells and inhibit this process in preosteoblastic MC3T3-E1 cells., PMID:39879823
Rhabdomyosarcoma With EWSR1::NF2 Gene Fusion: A Case Report Potentially Expanding Its Genetic Spectrum., PMID:39873201
Light-chain split luciferase assay implicates pathological NOTCH3 thiol reactivity in inherited cerebral small vessel disease., PMID:39864627
Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review., PMID:39858606
NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL., PMID:39853935
Type IV collagen expression is regulated by Notch3-mediated Notch signaling during angiogenesis., PMID:39842335
Traumatic brain injury causes early aggregation of beta-amyloid peptides and NOTCH3 reduction in vascular smooth muscle cells of leptomeningeal arteries., PMID:39841284
Intracerebral hemorrhage in CADASIL., PMID:39806999
Bioinformatic Analysis for Exploring Target Genes and Molecular Mechanisms of Cadmium-Induced Nonalcoholic Fatty Liver Disease and Targeted Drug Prediction., PMID:39806544
Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries., PMID:39792671
Mutational and co-mutational landscape of early onset colorectal cancer., PMID:39761813
Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models., PMID:39759869
FoxC1 activates Notch3 signaling to promote the inflammatory phenotype of keloid fibroblasts and aggravates keloid., PMID:39753198
A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells., PMID:39752389
Targeted exonic sequencing identifies novel variants in a cerebral small vessel disease cohort., PMID:39743006
A pilot study of transcriptomic preimplantation genetic testing (PGT-T): towards a new step in embryo selection?, PMID:39719045
Determining Clinical Disease Progression in Symptomatic Patients With CADASIL., PMID:39689282
For research use only. Not for human or drug use.
