Catalog No.
EHJ80401
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Glu180
Predicted molecular weight
20.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULV1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fz-4, Frizzled-4, CD344, FzE4, FZD4, hFz4
N-Glycosylation Modification of Fzd4 Is Essential for the Fzd4-Wnt-β-Catenin Signalling Axis., PMID:40230079
Underlying Disease in Atypical Retinopathy of Prematurity., PMID:40010420
Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel., PMID:39918476
Genotype-Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes., PMID:39903177
Congenital retinal folds., PMID:39884496
Wnt7B enhances the osteogenic differentiation of lipopolysaccharide-stimulated human periodontal ligament stem cells and inhibits the M1 polarization of macrophages by binding FZD4., PMID:39301638
Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation., PMID:39223191
Clinical and genetic characteristics and natural history of Finnish families with familial exudative vitreoretinopathy due to pathogenic FZD4 variants., PMID:38706142
FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4., PMID:38589650
Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations., PMID:38558095
Investigating the Impact of Dimer Interface Mutations on Norrin's Secretion and Norrin/β-Catenin Pathway Activation., PMID:38517429
Severe isolated exudative vitreoretinopathy caused by biallelic FZD4 variants., PMID:38361102
Screening Mutations of the Monogenic Syndromic High Myopia by Whole Exome Sequencing From MAGIC Project., PMID:38315492
Genetic Characteristics and Clinical Manifestations of Foveal Hypoplasia in Familial Exudative Vitreoretinopathy., PMID:38280677
Quality Control of Stem Cell-Based Cultured Meat According to Specific Differentiation Abilities., PMID:38247826
Clinical and genetic risk factors underlying severe consequence identified in 75 families with unilateral high myopia., PMID:38243264
ATOH8 Expression Is Regulated by BMP2 and Plays a Key Role in Human Endometrial Stromal Cell Decidualization., PMID:38060684
Mechanisms Underlying Rare Inherited Pediatric Retinal Vascular Diseases: FEVR, Norrie Disease, Persistent Fetal Vascular Syndrome., PMID:37947657
Folate deficiency promotes cervical squamous carcinoma SiHa cells progression by targeting miR-375/FZD4/β-catenin signaling., PMID:37926400
Long non coding RNA, C8orf49, a novel diagnostic and prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis by sponging miR-1323 in endometriosis., PMID:37557978
Identification of cuproptosis-related lncRNA for predicting prognosis and immunotherapeutic response in cervical cancer., PMID:37400520
YAP/WNT5A/FZD4 axis regulates osteogenic differentiation of human periodontal ligament cells under cyclic stretch., PMID:37340863
Deciphering the Cardiovascular Potential of Human CD34+ Stem Cells., PMID:37298503
Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR., PMID:37089697
18p Deletion Syndrome With Concurrent Frizzled-4 Mutation: Surgical Management of Bilateral Stage 5 Traction Retinal Detachment., PMID:37022334
m6A RNA methylation-mediated upregulation of HLF promotes intrahepatic cholangiocarcinoma progression by regulating the FZD4/β-catenin signaling pathway., PMID:36958694
[Fibroblasts overpressing WNT2b cause impairment of intestinal mucosal barrier]., PMID:36946039
The non-invasive diagnosis of colorectal cancer via a SOX9-based gene panel., PMID:36637582
A comprehensive functional analysis on the pathogenesis of novel TSPAN12 and NDP variants in familial exudative vitreoretinopathy., PMID:36453149
Familial exudative vitreoretinopathy (FEVR) in a child with novel microarray-defined deletion of 11q14 previously diagnosed as retinopathy of prematurity (ROP)., PMID:36444989
CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/β-catenin signaling due to modulating miR-671-5p/FZD4 axis., PMID:36434577
Clinical characteristics and mutation spectrum in 33 Chinese families with familial exudative vitreoretinopathy., PMID:36411543
Signal Peptide Variants in Inherited Retinal Diseases: A Multi-Institutional Case Series., PMID:36362148
Molecular characterization of early breast cancer onset to understand disease phenotypes in African patients., PMID:36352274
A regulatory circuit of lncRNA NLGN1-AS1 and Wnt signalling controls clear cell renal cell carcinoma phenotypes through FZD4-modulated pathways., PMID:36170021
Identification of Epigenetic Interactions between miRNA and Gene Expression as Potential Prognostic Markers in Bladder Cancer., PMID:36140796
Severe Familial Exudative Vitreoretinopathy, Congenital Hearing Loss, and Developmental Delay in a Child With Biallelic Variants in FZD4., PMID:35951321
Mutation spectrum in a cohort with familial exudative vitreoretinopathy., PMID:35876299
Genotype-phenotype associations in familial exudative vitreoretinopathy: A systematic review and meta-analysis on more than 3200 individuals., PMID:35830446
Long Chain Non Coding RNA Targeting miR Signal Axis Regulates the Mechanism of Apoptosis and Invasion and Migration of Glioma U251 Cells., PMID:35818202
Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo., PMID:35525270
MicroRNA-200a regulates skin pigmentation by targeting WNT5A and FZD4 in Cashmere goats., PMID:35461010
Update on the Phenotypic and Genotypic Spectrum of KIF11-Related Retinopathy., PMID:35456519
Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation., PMID:35418614
Circ_0001971 makes progress of oral squamous cell carcinoma by targeting miR-107/FZD4 axis., PMID:35403775
FZD4 in a Large Chinese Population With Familial Exudative Vitreoretinopathy: Molecular Characteristics and Clinical Manifestations., PMID:35394490
The expression profile of WNT/β-catanin signalling genes in human oocytes obtained from polycystic ovarian syndrome (PCOS) patients., PMID:35357301
Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in rheumatoid arthritis., PMID:35352610
A Survey of Multigenic Protein-Altering Variant Frequency in Familial Exudative Vitreo-Retinopathy (FEVR) Patients by Targeted Sequencing of Seven FEVR-Linked Genes., PMID:35328049
Whole exome sequencing revealed 14 variants in NDP, FZD4, LRP5, and TSPAN12 genes for 20 families with familial exudative vitreoretinopathy., PMID:35277167
For research use only. Not for human or drug use.
