Catalog No.
YHJ80301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu153-Arg557
Predicted molecular weight
48.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULM6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1194, CCR4, CNOT6, CCR4a, CCR4 carbon catabolite repression 4-like, Cytoplasmic deadenylase, Carbon catabolite repressor protein 4 homolog, CCR4-NOT transcription complex subunit 6
CNOT6L deadenylase suppresses cardiac remodeling in heart failure through downregulation of tenascin-C mRNA., PMID:40023604
The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT., PMID:39699231
Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity., PMID:39451207
Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease., PMID:39339346
Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks., PMID:39215079
Bioinformatics analysis of ferroptosis-related genes and immune cell infiltration in non-alcoholic fatty liver disease., PMID:38115130
CNOT6: A Novel Regulator of DNA Mismatch Repair., PMID:35159331
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1., PMID:35121990
CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development., PMID:34788619
Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex., PMID:34038562
The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis., PMID:34026442
A Novel RNA Binding Protein-Related Prognostic Signature for Hepatocellular Carcinoma., PMID:33251144
Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR)., PMID:33178865
Analysis of CNOT Family Gene Expression, Clinicopathological Features, and Prognosis Value in Hepatocellular Carcinoma., PMID:33085544
Silencing of CCR4-NOT complex subunits affects heart structure and function., PMID:32471864
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability., PMID:31924127
Differently Expressed Genes (DEGs) Relevant to Type 2 Diabetes Mellitus Identification and Pathway Analysis via Integrated Bioinformatics Analysis., PMID:31797865
Transcriptome profiling of longissimus thoracis muscles identifies highly connected differentially expressed genes in meat type sheep of India., PMID:31170190
CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway., PMID:31155293
mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells., PMID:31116665
Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis., PMID:30926667
CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation., PMID:29717177
Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains., PMID:28954224
Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs., PMID:27805284
Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia., PMID:27151989
The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells., PMID:27037025
miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways., PMID:26792405
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression., PMID:26541675
The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module., PMID:25944446
Deadenylase depletion protects inherited mRNAs in primordial germ cells., PMID:25100654
Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation., PMID:24142921
RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes., PMID:23337855
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex., PMID:23236473
The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex., PMID:22977175
Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex., PMID:22817755
Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker., PMID:22614729
Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development., PMID:21741365
CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death., PMID:21299754
The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence., PMID:21233283
hCCR4/cNOT6 targets DNA-damage response proteins., PMID:18818012
Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1., PMID:18180299
For research use only. Not for human or drug use.
