Catalog No.
YHJ80001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys181
Predicted molecular weight
22.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULC4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MCTS1, Multiple copies T-cell malignancies, MCT1, MCT-1, Malignant T-cell-amplified sequence 1
Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis., PMID:40204712
MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays., PMID:39748120
MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development., PMID:39240686
Differential effects of 40S ribosome recycling factors on reinitiation at regulatory uORFs in GCN4 mRNA are not dictated by their roles in bulk 40S recycling., PMID:39232119
Expression Regulation of Gluconeogenesis Related Genes in Ovine Skeletal Muscle Cells., PMID:38940053
Impacts of yeast Tma20/MCTS1, Tma22/DENR and Tma64/eIF2D on translation reinitiation and ribosome recycling., PMID:38903097
Identification of genes and key pathways underlying the pathophysiological association between sarcopenia and chronic obstructive pulmonary disease., PMID:38320732
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria., PMID:37875108
Proliferation-associated 2G4 P48 is stabilized by malignant T-cell amplified sequence 1 and promotes the proliferation of head and neck squamous cell carcinoma., PMID:37799877
MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination., PMID:37634410
Relocalization of Translation Termination and Ribosome Recycling Factors to Stress Granules Coincides with Elevated Stop-Codon Readthrough and Reinitiation Rates upon Oxidative Stress., PMID:36672194
Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players., PMID:35741757
Screening the Potential Biomarkers of COVID-19-Related Thrombosis Through Bioinformatics Analysis., PMID:35692833
Identification of a combined apoptosis and hypoxia gene signature for predicting prognosis and immune infiltration in breast cancer., PMID:35441810
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability., PMID:35274760
Non-canonical initiation factors modulate repeat-associated non-AUG translation., PMID:35220421
Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs., PMID:35197532
Identification of immune-related cells and genes in the breast invasive carcinoma microenvironment., PMID:35120331
Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division., PMID:35115540
Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress., PMID:35017469
CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation., PMID:35008603
Etodolac improves collagen induced rheumatoid arthritis in rats by inhibiting synovial inflammation, fibrosis and hyperplasia., PMID:35006449
Identification of the Upregulation of MRPL13 as a Novel Prognostic Marker Associated with Overall Survival Time and Immunotherapy Response in Breast Cancer., PMID:34868337
Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma., PMID:34704820
MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma., PMID:34668521
The Role of the MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation., PMID:34377560
MCTS1 promotes the development of lung adenocarcinoma by regulating E2F1 expression., PMID:34079590
DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4., PMID:32938922
MCTS1 Directly Binds to TWF1 and Synergistically Modulate Cyclin D1 and C-Myc Translation in Luminal A/B Breast Cancer Cells., PMID:32606753
Genetic association research in football: A systematic review., PMID:32466725
Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury., PMID:32160403
Isoorientin Decreases Cell Migration via Decreasing Functional Activity and Molecular Expression of Proton-Linked Monocarboxylate Transporters in Human Lung Cancer Cells., PMID:31918564
Multiple Copies in T-Cell Malignancy 1 (MCT-1) Promotes the Stemness of Non-Small Cell Lung Cancer Cells via Activating Interleukin-6 (IL-6) Signaling through Suppressing MiR-34a Expression., PMID:31891569
MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer., PMID:30885232
Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation., PMID:30584092
The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer., PMID:30521130
Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo., PMID:30146315
DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation., PMID:29889857
A tandem mass tag (TMT) proteomic analysis during the early phase of experimental pancreatitis reveals new insights in the disease pathogenesis., PMID:29678717
PKC inhibition of sotrastaurin has antitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1., PMID:29534146
Structural and Functional Insights into Human Re-initiation Complexes., PMID:28732596
Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1., PMID:28723557
Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells., PMID:28623304
Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism., PMID:28260082
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells., PMID:28258651
GLUT1, MCT1/4 and CD147 overexpression supports the metabolic reprogramming in papillary renal cell carcinoma., PMID:28028797
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity., PMID:27294876
De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation., PMID:27239039
Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method., PMID:26699426
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment., PMID:26563366
For research use only. Not for human or drug use.
