Catalog No.
YHJ79201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala18-Asn248
Predicted molecular weight
27.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKR0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Kallikrein-like protein 5, KLK-L5, Kallikrein-12, KLK12, KLKL5
Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer., PMID:39757274
Nanoparticles target M2 macrophages to silence kallikrein-related peptidase 12 for the treatment of tuberculosis and drug-resistant tuberculosis., PMID:39305944
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation., PMID:39163389
Unveiling the Genomic Landscape of Intraductal Carcinoma of the Prostate Using Spatial Gene Expression Analysis., PMID:38732035
Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors., PMID:37591246
Early detection of squamous cell carcinoma of the oral tongue using multidimensional plasma protein analysis and interpretable machine learning., PMID:37428440
Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker., PMID:37176127
Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer., PMID:37139608
KLK12 Regulates MMP-1 and MMP-9 via Bradykinin Receptors: Biomarkers for Differentiating Latent and Active Bovine Tuberculosis., PMID:36293113
Epigenetics of Triple-Negative Breast Cancer via Natural Compounds., PMID:34238140
Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor., PMID:33977679
Gene Expression of Kallikreins in Breast Cancer Cell Lines., PMID:32366393
Silencing KLK12 expression via RGDfC-decorated selenium nanoparticles for the treatment of colorectal cancer in vitro and in vivo., PMID:32204058
Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients., PMID:32028882
Kallikrein-related peptidases protein expression in lymphoid tissues suggests potential implications in immune response., PMID:31904348
Knockdown of KLK12 inhibits viability and induces apoptosis in human colorectal cancer HT-29 cell line., PMID:31485623
CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer., PMID:31378128
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis., PMID:31060300
Identifying Candidate Biomarkers for Pleomorphic Adenoma: A Case-Control Study., PMID:30120721
Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology., PMID:29874189
Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors., PMID:29807016
Human kallikrein-related peptidase 12 stimulates endothelial cell migration by remodeling the fibronectin matrix., PMID:29679011
Kallikrein-related peptidases in lung diseases., PMID:29604204
A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site., PMID:28358853
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia., PMID:28000848
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration., PMID:27706634
Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models., PMID:27442805
Identification, Molecular Characterization and Alternative Splicing of Three Novel Members of the Canine Kallikrein (Klk)-related Peptidase Family., PMID:25964550
Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows., PMID:25550244
SigFuge: single gene clustering of RNA-seq reveals differential isoform usage among cancer samples., PMID:25030904
Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury., PMID:24352040
Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway., PMID:24225148
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12., PMID:23612974
Clinical significance of human kallikrein 12 gene expression in gastric cancer., PMID:23236234
Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor., PMID:23152405
Elevated immunoglobulin to tissue KLK11 in patients with Sjögren syndrome., PMID:23086370
Human kallikrein-related peptidase 12 (KLK12) splice variants expression in breast cancer and their clinical impact., PMID:22351561
Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin., PMID:21753780
Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness., PMID:21741862
Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors., PMID:21628462
Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6., PMID:21439340
Potential role of multiple members of the kallikrein-related peptidase family of serine proteases in activating latent TGF beta 1 in semen., PMID:19919178
Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis., PMID:18697857
Kallikreins as microRNA targets: an in silico and experimental-based analysis., PMID:18627289
Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues., PMID:17654496
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)., PMID:17391064
Rapid, high-quality and epidermal-specific isolation of RNA from human skin., PMID:17286810
Characterization of human kallikreins 6 and 10 in ascites fluid from ovarian cancer patients., PMID:16864975
In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families., PMID:16829021
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity., PMID:15300858
For research use only. Not for human or drug use.
