Catalog No.
YHJ78701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe404-Ser673
Predicted molecular weight
32.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKG1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APPL1, Dip13-alpha, APPL, DIP13A, DCC-interacting protein 13-alpha, KIAA1428, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
Endosomal H2O2 Molecules Act as Signaling Mediators in Akt/PKB Activation., PMID:40427476
Adiponectin receptor agonist AdipoRon regulates glucose and lipid metabolism via PPARγ signaling pathway in hepatocytes of large yellow croaker (Larimichthys crocea)., PMID:40379087
Exploring the therapeutic potential of HAPC in COVID-19-induced acute lung injury., PMID:40023068
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling., PMID:39562139
Spatial-temporal regulation of the prostanoid receptor EP2 co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium., PMID:39555416
Unraveling the genetic basis of MODY: insights from next-generation sequencing., PMID:39361122
Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration., PMID:39345644
Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction., PMID:39287861
Exploring the Logic and Conducting a Comprehensive Evaluation of the Adiponectin Receptor Agonists AdipoRon and AdipoAI's Impacts on Bone Metabolism and Repair-A Systematic Review., PMID:39206478
Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers., PMID:39117701
Adenosine kinase inhibits β-cell proliferation by upregulating DNA methyltransferase 3A expression., PMID:38699782
METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes., PMID:38664788
Constitutive internalisation of EP2 differentially regulates G protein signalling., PMID:38639976
Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients., PMID:38464380
Antidiabetic features of AdipoAI, a novel AdipoR agonist., PMID:38269524
Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids., PMID:38157366
A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and early endosomes in hepatitis E virus replication., PMID:38109552
Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus., PMID:38054414
Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury., PMID:37795615
Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism., PMID:37532690
MicroRNA-668-3p inhibits myoblast proliferation and differentiation by targeting Appl1., PMID:37488537
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo., PMID:37429524
Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread., PMID:37422404
Novel Histopathological Biomarkers in Prostate Cancer: Implications and Perspectives., PMID:37371647
Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis., PMID:37187293
Contribution of vesicle trafficking dysregulation to the pathomechanism of mucopolysaccharidosis., PMID:37149983
AdipoAI suppresses osteoclastogenesis by activating AdipoR1/APPL1: An in vivo experimental study in diabetes-associated peri-implantitis., PMID:37092468
Adiponectin-mediated promotion of CD44 suppresses diabetic vascular inflammatory effects., PMID:37020952
Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice., PMID:36860545
APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma., PMID:36846720
NMDA Receptor-Dependent Synaptic Potentiation via APPL1 Signaling Is Required for the Accessibility of a Prefrontal Neuronal Assembly in Retrieving Fear Extinction., PMID:36842495
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats., PMID:36716441
Probiotic Yogurt Alleviates High-Fat Diet-Induced Lipid Accumulation and Insulin Resistance in Mice via the Adiponectin Pathway., PMID:36695046
Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome., PMID:36340038
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells., PMID:36302621
Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer., PMID:36089417
Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis., PMID:35984564
The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells., PMID:35853811
Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats., PMID:35720361
Active APPL1 sequestration by Plasmodium favors liver-stage development., PMID:35649358
DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway., PMID:35509834
Exercise ameliorates high-fat diet-induced insulin resistance accompanied by changes in protein levels of hepatic ATF3-related signaling in rats., PMID:35240124
A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy., PMID:35196181
APPL1 ameliorates myocardial ischemia-reperfusion injury by regulating the AMPK signaling pathway., PMID:35069838
Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats., PMID:34973346
Tetrahydrocurcumin Upregulates the Adiponectin-AdipoR Pathway and Improves Insulin Signaling and Pancreatic β-Cell Function in High-Fat Diet/Streptozotocin-Induced Diabetic Obese Mice., PMID:34960104
Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice., PMID:34925690
LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion injury by sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway., PMID:34919285
Quantitative correlative microscopy reveals the ultrastructural distribution of endogenous endosomal proteins., PMID:34817533
The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages., PMID:34789781
For research use only. Not for human or drug use.
