Catalog No.
YHJ78601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu1650-Ala1901
Predicted molecular weight
29.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKA4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
A-kinase anchor protein 220 kDa, KIAA0629, A-kinase anchor protein 11, AKAP11, hAKAP220, AKAP-11, Protein kinase A-anchoring protein 11, PRKA11, AKAP220, AKAP 220
Schizophrenia-Related Synaptic Dysfunction and Abnormal Sensorimotor Gating in Akap11-Deficient Mice., PMID:40408419
Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia., PMID:40316678
Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling., PMID:40263600
Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2., PMID:40204782
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission., PMID:40162211
Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorder., PMID:40133559
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission., PMID:39803523
Autophagosomes coordinate an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling., PMID:39211170
Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons., PMID:38600097
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia., PMID:37207277
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model., PMID:37171958
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations., PMID:36914870
Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients., PMID:36914641
Common variants associated with AKAP11 expression confer risk of bipolar disorder., PMID:36179529
Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing., PMID:36071494
Genetic variation as a long-distance modulator of RAD21 expression in humans., PMID:35906355
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia., PMID:35410376
Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels., PMID:35328741
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth., PMID:33785595
A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations., PMID:33249669
Gene-gene and gene-lifestyle interactions of AKAP11, KCNMA1, PUM1, SPTBN1, and EPDR1 on osteoporosis risk in middle-aged adults., PMID:32619791
Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process., PMID:31740454
AKAP11 gene polymorphism is associated with bone mass measured by quantitative ultrasound in young adults., PMID:30013441
Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer., PMID:29528523
The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β., PMID:27484798
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2., PMID:27476799
AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption., PMID:27402760
Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II)., PMID:26821332
PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation., PMID:25188285
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density., PMID:24249740
AKAP220 protein organizes signaling elements that impact cell migration., PMID:21890631
Isoform-specific targeting of PKA to multivesicular bodies., PMID:21502359
Anchored protein kinase A recruitment of active Rac GTPase., PMID:21460214
Differential gene expression in human granulosa cells from recombinant FSH versus human menopausal gonadotropin ovarian stimulation protocols., PMID:20226040
Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance., PMID:19587378
Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis., PMID:15849745
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta., PMID:12147701
AKAP mediated signal transduction., PMID:11807172
Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation., PMID:11152471
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis., PMID:10864471
Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220., PMID:10209101
Anchoring and scaffold proteins for kinases and phosphatases., PMID:9238861
Properties of A-kinase anchoring proteins., PMID:8968497
Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes., PMID:8621616
For research use only. Not for human or drug use.
