Catalog No.
YHJ78501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly243-Ala372
Predicted molecular weight
17.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UK59
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lariat debranching enzyme, DBR1
Intron-Derived Lariat RNAs Go Stable., PMID:40033900
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity., PMID:39636299
Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance., PMID:39227617
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency., PMID:39023559
The debranching enzyme Dbr1 regulates lariat turnover and intron splicing., PMID:38816363
Cretan HLA genetics supports its early Minoan culture as a link between North Africa and Europe., PMID:38637221
Genetic causes of infection induced encephalitis., PMID:38564873
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance., PMID:38177131
Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation., PMID:37800682
A founder DBR1 variant causes a lethal form of congenital ichthyosis., PMID:37656279
Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain., PMID:37507019
The debranching enzyme Dbr1 regulates lariat turnover and intron splicing., PMID:37398028
Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs., PMID:36974901
An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching., PMID:36943791
Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product., PMID:36484984
Intron turnover is essential to the development and pathogenicity of the plant pathogenic fungus Fusarium graminearum., PMID:36289323
SICKLE modulates lateral root development by promoting degradation of lariat intronic RNA., PMID:35788403
Metal content and kinetic properties of yeast RNA lariat debranching enzyme Dbr1., PMID:35459748
The Role of DBR1 as a Candidate Prognosis Biomarker in Esophageal Squamous Cell Carcinoma., PMID:35244467
Neuron-intrinsic immunity to viruses in mice and humans., PMID:34425410
Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections., PMID:33386334
Dbr1 functions in mRNA processing, intron turnover and human diseases., PMID:33038423
Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification., PMID:32924658
Mutation of leucine 20 causes a change of local conformation indirectly impairing the DNA binding of SP_0782 from Streptococcus pneumoniae., PMID:31980174
Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs., PMID:31914145
Postsplicing-Derived Full-Length Intron Circles in the Protozoan Parasite Entamoeba histolytica., PMID:30123775
Unexplored Molecular Features of the Entamoeba histolytica RNA Lariat Debranching Enzyme Dbr1 Expression Profile., PMID:30023353
Cloning and characterization of enoate reductase with high β-ionone to dihydro-β-ionone bioconversion productivity., PMID:29743047
Genome-Wide Identification of circRNAs in Pathogenic Basidiomycetous Yeast Cryptococcus neoformans Suggests Conserved circRNA Host Genes over Kingdoms., PMID:29495353
Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection., PMID:29474921
Conformational Changes in the 5' End of the HIV-1 Genome Dependent on the Debranching Enzyme DBR1 during Early Stages of Infection., PMID:28931690
Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development., PMID:28504715
Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1., PMID:27930312
Intron Lariat RNA Inhibits MicroRNA Biogenesis by Sequestering the Dicing Complex in Arabidopsis., PMID:27870853
Mechanistic insights into the manganese-dependent phosphodiesterase activity of yeast Dbr1 with bis-p-nitrophenylphosphate and branched RNA substrates., PMID:27765821
In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity., PMID:26797105
Significance of the differences in the prevalence of anti-HLA antibodies in matched pairs of mother's and cord blood., PMID:26721232
Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA., PMID:26715653
Obstructive sleep apnoea syndrome and HLA in the North of Portugal., PMID:26411274
ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae., PMID:25803831
Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein., PMID:25671812
Saturation editing of genomic regions by multiplex homology-directed repair., PMID:25141179
Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1., PMID:25123664
Alzheimer's disease risk genes and mechanisms of disease pathogenesis., PMID:24951455
Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome., PMID:24931452
A homolog of lariat-debranching enzyme modulates turnover of branched RNA., PMID:24919400
LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq., PMID:24709818
Impairment of HIV-1 cDNA synthesis by DBR1 knockdown., PMID:24672043
The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction., PMID:23681507
[Research progresses in synthetic biology of artemisinin]., PMID:23672015
For research use only. Not for human or drug use.
