Catalog No.
YHJ78301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu45-His260
Predicted molecular weight
25.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UJU2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, LEF-1, TCF1-alpha, LEF1
Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation., PMID:40515848
MBD2 promotes B cell differentiation and BCR signaling in systemic lupus erythematosus by regulating the LEF-1-PTEN-PI3K axis., PMID:40467564
Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice., PMID:40464222
ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP-Wnt pathway., PMID:40456828
LEF1-AS1 Deregulation in the Peripheral Blood of Patients with Persistent Post-COVID Symptoms., PMID:40429947
Analysis of immune infiltration in basal cell carcinoma based on transcriptome sequencing and experimental validation of diagnostic biomarkers., PMID:40410644
A Selective GSK3β Inhibitor, Tideglusib, Decreases Intermittent Access and Binge Ethanol Self-Administration in C57BL/6J Mice., PMID:40390305
NAMPT-mediated deacetylation of HCLS1 protein promotes clonogenic growth of pediatric CML cells., PMID:40349748
Impact of MiRNAs on Wnt-related gene activity in breast cancer., PMID:40346182
Inhibition of Fin Regeneration in Fathead Minnow (Pimephales promelas) by a Potent Synthetic Glucocorticoid and Development of Adverse Outcome Pathway 334., PMID:40326831
Diagnostic insights into solid pseudopapillary neoplasms of the pancreas: a decade of experience with pediatric representation., PMID:40307756
USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells., PMID:40301985
β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells., PMID:40301545
miR-143-3p Promotes TSCM Differentiation and Inhibits Progressive T Cell Differentiation via Inhibiting ABL2 and PAG1., PMID:40282426
NLK knockdown in hBMSCs enhance repair of critical-size bone defects by modulating neurogenic and osteogenic differentiation., PMID:40280200
Identification of MEOX1 as a potential target in metabolic dysfunction-associated steatohepatitis-related liver fibrosis., PMID:40270091
Fate and state transitions during human blood vessel organoid development., PMID:40250419
The Possible Role of Wnt/β-Catenin Pathway in Central Neurocytoma., PMID:40154600
Mucoepidermoid Carcinoma Associated with an Intercalated Duct Lesion: Precursor or Coincidence?, PMID:40138019
Wnt/β-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration., PMID:40130164
LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC., PMID:40093269
Conformational ensembles for protein structure prediction., PMID:40074747
Construction of Large-Scale Bioengineered Hair Germs and In Vivo Transplantation., PMID:40042061
Integrative transcriptomic and metabolomic analyses reveal the role of melatonin in promoting secondary hair follicle development in cashmere goats., PMID:40016679
The influence of lymphoid enhancer binding factor-1 expression on the outcome of adult acute promyelocytic leukemia patients., PMID:39960008
A Novel tRF, HCETSR, Derived From tRNA-Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1-catenin Complex Axis., PMID:39921434
Diagnostic utility of lymphocyte enhancer factor 1 in aggressive B-cell lymphoma with MYC rearrangement., PMID:39912808
Vdr mediates Wnt signaling pathway to regulate odontoblasts differentiation during dentin apposition., PMID:39894431
Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7-driven Small Cell Lung Cancer., PMID:39887933
Expression of Lymphoid Enhancer-Binding Factor 1 in Cancer-Associated Fibroblasts Mediates Tumor Growth and Transdifferentiation Toward Squamous Cell Carcinoma in Human Breast Cancer., PMID:39887653
Diagnostic utility of LEF1 and β-catenin in WNT pathway tumors with CTNNB1 mutation., PMID:39881334
Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma., PMID:39851951
Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m6A regulation., PMID:39849105
The molecule events expression of TGF-β/Smad signaling pathway in morphological and structural developmental characteristics of gonads in goose embryos., PMID:39823842
Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies., PMID:39820173
Elevated MRPS23 expression facilitates aggressive phenotypes in breast cancer cells., PMID:39799495
Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis., PMID:39794729
Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity., PMID:39762891
Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status., PMID:39738380
Prader-Willi syndrome protein necdin regulates the nucleocytoplasmic distribution and dopaminergic neuron development., PMID:39738217
Regulation of the β‑catenin/LEF‑1 pathway by the siRNA knockdown of RUVBL1 expression inhibits breast cancer cell proliferation, migration and invasion., PMID:39670302
Gpr54 deletion accelerates hair cycle and hair regeneration., PMID:39587329
Wnt signaling aberrant activation drives ameloblastoma invasion and recurrence: bioinformatics and in vitro insights., PMID:39574093
Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids., PMID:39567475
Refining Diagnostic Subtypes of Peripheral T-Cell Lymphoma Using a Multiparameter Approach., PMID:39491745
Peptide Cy RL-QN15 accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor., PMID:39479995
LEF1 is associated with immunosuppressive microenvironment of patients with lung adenocarcinoma., PMID:39465830
CRABP1 Enhances the Proliferation of the Dermal Papilla Cells of Hu Sheep through the Wnt/β-catenin Pathway., PMID:39457415
Role of Immunohistochemistry in the Diagnosis of Pilomatrical Tumors., PMID:39450990
TCF4 as a potential prognostic biomarker and an anticancer target in gastric cancer., PMID:39430834
For research use only. Not for human or drug use.
