Catalog No.
YHJ77801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly349
Predicted molecular weight
40.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UIM3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FK506-binding protein-like, DIR1, FKBPL, NG7, WISp39, WAF-1/CIP1 stabilizing protein 39
The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation., PMID:40069829
A long noncoding RNA with enhancer-like function in pig zygotic genome activation., PMID:39749834
Point-of-Care Tests for Preeclampsia: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies., PMID:39663778
ER quality control through reticulophagy and protein secretion., PMID:39603274
Identifying therapeutic targets for kidney stone disease through proteome-wide Mendelian randomization and colocalization analysis., PMID:39585470
Cytosolic FKBPL and ER-resident CKAP4 co-regulates ER-phagy and protein secretion., PMID:39251576
Proteome-wide mendelian randomization identifies therapeutic targets for nephrolithiasis., PMID:39237840
Integrative analysis reveals novel insights into juvenile idiopathic arthritis pathogenesis and shared molecular pathways with associated traits., PMID:39175752
Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis., PMID:38566994
Expression and role of FKBPL in lung adenocarcinoma., PMID:38164287
Improving Women's Health., PMID:37665233
Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy., PMID:37499939
Vitamins C and D Exhibit Similar Antidepressant Effects to Escitalopram Mediated by NOx and FKBPL in a Stress-Induced Mice Model., PMID:37375593
Quantitative Point of Care Tests for Timely Diagnosis of Early-Onset Preeclampsia with High Sensitivity and Specificity., PMID:37055349
E-Cigarette Aerosol Condensate Leads to Impaired Coronary Endothelial Cell Health and Restricted Angiogenesis., PMID:37047355
FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility., PMID:36830764
A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia., PMID:36652019
Loss of Expression of Antiangiogenic Protein FKBPL in Endometrioid Endometrial Carcinoma: Implications for Clinical Practice., PMID:36295491
FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury., PMID:35101451
Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia., PMID:34435509
A novel mutation in FK506 binding protein-like (FKBPL) causes male infertility., PMID:34212559
FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function., PMID:34149611
Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia., PMID:33879252
FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease., PMID:33303872
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention., PMID:32622856
Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment., PMID:32617576
FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer., PMID:31772325
Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair., PMID:31676385
FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4., PMID:30975104
An improved reversibly dimerizing mutant of the FK506-binding protein FKBP., PMID:27738551
Low-frequency nonsynonymous variants in FKBPL and ARPC1B genes are associated with breast cancer risk in Chinese women., PMID:27479355
Associations of 6p21.3 Region with Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy., PMID:26861912
RALA-mediated delivery of FKBPL nucleic acid therapeutics., PMID:26419658
Novel endogenous angiogenesis inhibitors and their therapeutic potential., PMID:26364800
WISp39 and Hsp90: actin' together in cell migration., PMID:26257007
Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations., PMID:25937444
FKBPL: a marker of good prognosis in breast cancer., PMID:25906750
WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility., PMID:25800056
FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis., PMID:25767277
Biological relevance of Hsp90-binding immunophilins in cancer development and treatment., PMID:25754838
Molecular cochaperones: tumor growth and cancer treatment., PMID:24278769
Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen., PMID:23912458
Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway., PMID:23741069
The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway., PMID:23457460
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3., PMID:22694956
The therapeutic and diagnostic potential of FKBPL; a novel anticancer protein., PMID:22265918
The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL., PMID:21428958
FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism., PMID:21364036
Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype., PMID:20479757
Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study., PMID:20210997
For research use only. Not for human or drug use.
