Catalog No.
YHJ77301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile305-Arg384
Predicted molecular weight
11.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UI42
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CPA3, Carboxypeptidase A4, CPA4, Carboxypeptidase A3
Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies., PMID:40414875
CPA4 overexpression correlates with poor prognosis and tumor progression in endometrial cancer., PMID:40089797
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
Macrophage-Induced Carboxypeptidase A4 Promotes the Progression of Anaplastic Thyroid Cancer., PMID:38666696
CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells., PMID:38494845
CircCPA4 induces ASCT2 expression to promote tumor property of non-small cell lung cancer cells in a miR-145-5p-dependent manner., PMID:38400818
circRNA-CPA4 Regulates Cell Proliferation and Apoptosis of Non-small Cell Lung Cancer via the miR-1183/PDPK1 Axis., PMID:38273153
circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop., PMID:38219533
Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway., PMID:38049405
Rapid characterization of anti-CRISPR proteins and optogenetically engineered variants using a versatile plasmid interference system., PMID:37930830
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197., PMID:37410095
Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4., PMID:37162264
Knockdown of carboxypeptidase A4 (CPA4) inhibits gastric cancer cell progression via cell cycle arrest and apoptosis., PMID:36636089
The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells., PMID:36361992
Comprehensive Analysis of CPA4 as a Poor Prognostic Biomarker Correlated with Immune Cells Infiltration in Bladder Cancer., PMID:34827136
Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer., PMID:34741437
Therapeutic Potential of Human Nasal Inferior Turbinate-Derived Stem Cells: Microarray Analysis of Multilineage Differentiation., PMID:34488222
Establish six-gene prognostic model for glioblastoma based on multi-omics data of TCGA database., PMID:34284982
Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non-small cell lung cancer., PMID:33934493
Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells., PMID:33746592
HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells., PMID:33203807
Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)., PMID:32746878
Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling., PMID:32347291
Identification of potential microRNAs and their targets in promoting gefitinib resistance by integrative network analysis., PMID:32030273
Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease., PMID:31927669
Downregulation of CPA4 inhibits non small-cell lung cancer growth by suppressing the AKT/c-MYC pathway., PMID:31397502
Monoclonal antibody AC10364 inhibits cell proliferation in 5-fluorouracil resistant hepatocellular carcinoma via apoptotic pathways., PMID:31303763
Carboxypeptidase A4 promotes cell growth via activating STAT3 and ERK signaling pathways and predicts a poor prognosis in colorectal cancer., PMID:31279884
Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated with Placental Cadmium Concentrations and Birth Size., PMID:31082282
Carboxypeptidase A4 promotes proliferation and stem cell characteristics of hepatocellular carcinoma., PMID:31058377
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma., PMID:28475748
Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) - a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity., PMID:28209092
Altered Expression of Imprinted Genes in Squamous Cell Carcinoma of the Head and Neck., PMID:27127130
Cell Pluripotency Levels Associated with Imprinted Genes in Human., PMID:26504487
Revealing Glycoproteins in the Secretome of MCF-7 Human Breast Cancer Cells., PMID:26167486
A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4., PMID:23746805
Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4., PMID:22294694
Complementary positional proteomics for screening substrates of endo- and exoproteases., PMID:20526345
Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing., PMID:20385563
Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin., PMID:15738388
Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32., PMID:14962666
The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome., PMID:12676894
The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain., PMID:12552318
Identification and characterization of three members of the human metallocarboxypeptidase gene family., PMID:11836249
For research use only. Not for human or drug use.
