Catalog No.
YHJ77101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn347-Ser509
Predicted molecular weight
19.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UHX3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EMR2, EGF-like module receptor 2, ADGRE2, EGF-like module-containing mucin-like hormone receptor-like 2, Adhesion G protein-coupled receptor E2, CD312
CD312 Promotes Paediatric Acute Lymphoblastic Leukaemia Through GNA15-Mediated Non-Classical GPCR Signalling Pathway., PMID:39656442
Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia., PMID:39082681
The Posttraumatic Increase of the Adhesion GPCR EMR2/ADGRE2 on Circulating Neutrophils Is Not Related to Injury Severity., PMID:37998392
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain., PMID:33497605
Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes., PMID:33488598
Clinical Impact of Inherited and Acquired Genetic Variants in Mastocytosis., PMID:33401724
Historical Anecdotes and Breakthroughs of Histamine: From Discovery to Date., PMID:32727338
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2., PMID:32222457
G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody., PMID:31969668
The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis., PMID:31594642
Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia., PMID:31337736
Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies., PMID:31273197
Expanding the phenotypic and genetic spectrum of Chinese patients with congenital absence of vas deferens bearing CFTR and ADGRG2 alleles., PMID:30811104
The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells., PMID:30728423
Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation., PMID:30445064
Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study., PMID:30291379
Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation., PMID:29540735
miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer., PMID:29072692
Affinity Binding of EMR2 Expressing Cells by Surface-Grafted Chondroitin Sulfate B., PMID:28437084
Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients., PMID:27905560
CD97/ADGRE5 Inhibits LPS Induced NF-κB Activation through PPAR-γ Upregulation in Macrophages., PMID:26997758
Vibratory Urticaria Associated with a Missense Variant in ADGRE2., PMID:26841242
Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation., PMID:26153037
Composition of lymphocyte subpopulations in normal canine lymph nodes., PMID:25512102
Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas., PMID:25200831
Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains., PMID:22310662
EMR2 receptor ligation modulates cytokine secretion profiles and cell survival of lipopolysaccharide-treated neutrophils., PMID:22035891
F4/80 and the related adhesion-GPCRs., PMID:21952799
Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma., PMID:21503828
Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival., PMID:21174063
Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease., PMID:20167235
Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors., PMID:18267122
Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function., PMID:17928360
The role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-G protein-coupled receptors., PMID:17620333
CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells., PMID:17174274
Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies., PMID:16918507
Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue., PMID:15693006
Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells., PMID:15498814
Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif., PMID:15150276
Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule., PMID:15103144
Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif., PMID:12860403
The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans., PMID:12829604
Detection of alternatively spliced EMR2 mRNAs in colorectal tumor cell lines but rare expression of the molecule in colorectal adenocarcinomas., PMID:12761622
CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas., PMID:12428789
The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells., PMID:11994511
Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex., PMID:11297558
Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97., PMID:10903844
For research use only. Not for human or drug use.
