Catalog No.
YHJ75901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile33-Ala126
Predicted molecular weight
37.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UHD9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N4BP4, UBQLN2, Ubiquilin-2, Ubiquitin-like product Chap1/Dsk2, DSK2 homolog, PLIC-2, hPLIC-2, PLIC2, Protein linking IAP with cytoskeleton 2, Chap1
Defective autophagy in a fibroin secretion-deficient silkworm mutant., PMID:40413758
Bioinformatics analysis of oxidative phosphorylation-related differentially expressed genes in osteoporosis., PMID:40241169
Endoplasmic reticulum stress and unfolded protein response play roles in recurrent pregnancy loss: A bioinformatics study., PMID:39923360
Chronic Oxidative Stress and Stress Granule Formation in UBQLN2 ALS Neurons: Insights into Neuronal Degeneration and Potential Therapeutic Targets., PMID:39769213
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties., PMID:39484508
ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2ALS phenotypes in Drosophila melanogaster., PMID:39395630
Prion protein pathology in Ubiquilin 2 models of ALS., PMID:39299489
Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate., PMID:39121161
The structural and biophysical basis of substrate binding to the hydrophobic groove in Ubiquilin Sti1 domains., PMID:39026758
Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats., PMID:38990251
Two new cases with the UBQLN2 gene mutation in Han Chinese., PMID:38943019
High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)., PMID:38879591
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations., PMID:38872230
Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia., PMID:38703371
Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate., PMID:38559018
Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity., PMID:38472280
Autophagy Markers Are Altered in Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia., PMID:38256197
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833
Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia., PMID:38115557
Short disordered termini and proline-rich domain are major regulators of UBQLN1/2/4 phase separation., PMID:38041404
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units., PMID:37824531
Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4., PMID:37808720
Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein., PMID:37565261
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture., PMID:37501540
Loss-of-function variant in the ovine TMCO6 gene in North Country Cheviot sheep with motor neuron disease., PMID:37488055
UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells., PMID:37444499
The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence., PMID:37359784
Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid-Liquid Phase Separation., PMID:37276246
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways., PMID:37257946
Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS., PMID:37208601
Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components., PMID:37160462
Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2., PMID:37039476
We con-dense if we want to; We can't leave AZUL outside., PMID:37028393
Decoding optimal ligand design for multicomponent condensates., PMID:36993708
UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS., PMID:36951542
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure., PMID:36827983
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1., PMID:36674783
Silencing UBQLN2 Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma (ESCC) via Activating p38 MAPK., PMID:36644234
Ubiquilin-2 regulates pathological alpha-synuclein., PMID:36609661
UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding., PMID:36423739
Mutation spectrum of chinese amyotrophic lateral sclerosis patients with frontotemporal dementia., PMID:36345033
Neuronal Puncta/Aggregate Formation by WT and Mutant UBQLN2., PMID:36310225
An Optimized Stress Granule Detection Method: Investigation of UBQLN2 Effect on Stress Granule Formation., PMID:36310224
A Spectrophotometric Turbidity Assay to Study Liquid-Liquid Phase Separation of UBQLN2 In Vitro., PMID:36310223
Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2P497H Mutation., PMID:36232630
Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice., PMID:36099783
Behavioral and Cognitive Phenotypes of Patients With Amyotrophic Lateral Sclerosis Carrying SOD1 Variants., PMID:35985819
Genetic Spectrum and Clinical Heterogeneity of Chinese Frontotemporal Dementia Patients: Data from PUMCH Dementia Cohort., PMID:35964197
Role of Ubiquilin-2 in Proteostasis and Tau Aggregation in Tauopathies., PMID:35948434
For research use only. Not for human or drug use.
