Catalog No.
YHJ75301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg190
Predicted molecular weight
25.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UH17
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA dC->dU-editing enzyme APOBEC-3B, Phorbolin-1-related protein, A3B, Phorbolin-2/3, APOBEC3B
Kaposi's sarcoma-associated herpesvirus ORF61 protein sequesters APOBEC3B in filamentous aggregates., PMID:40470958
Precise detection of differential RNA editing sites across varied biological conditions using the CADRES pipeline., PMID:40467918
APOBEC affects tumor evolution and age at onset of lung cancer in smokers., PMID:40394004
APOBEC3 Activity Promotes the Survival and Evolution of Drug-Tolerant Persister Cells during EGFR Inhibitor Resistance in Lung Cancer., PMID:40323013
Purification of enzymatically active APOBEC proteins from an insect cell expression system., PMID:40250960
An in vitro cytidine deaminase assay to monitor APOBEC activity on DNA., PMID:40250954
Defining APOBEC-induced mutation signatures and modifying activities in yeast., PMID:40250951
Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe., PMID:40238882
APOBEC3B Does Not Promote Tumor Progression in Tp53 Hemizygous Mice., PMID:40213992
Comprehensive Analysis of Roles of APOBEC3 Gene Family in Clear Cell Renal Cell Carcinoma., PMID:40191862
APOBEC3 Proteins: From Antiviral Immunity to Oncogenic Drivers in HPV-Positive Cancers., PMID:40143363
NAT10 and N4-acetylcytidine restrain R-loop levels and related inflammatory responses., PMID:40138394
Regulatory Interactions between APOBEC3B N- and C-Terminal Domains., PMID:40105360
Complex rearrangements fuel ER+ and HER2+ breast tumours., PMID:39779850
APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats., PMID:39772743
Untargeted Mutation Triggered by Ribonucleoside Embedded in DNA., PMID:39769470
Regulatory interactions between APOBEC3B N- and C-terminal domains., PMID:39713448
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes., PMID:39680033
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma., PMID:39548236
Validation of the APOBEC3A-Mediated RNA Single Base Substitution Signature and Proposal of Novel APOBEC1, APOBEC3B, and APOBEC3G RNA Signatures., PMID:39510348
Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis., PMID:39443671
APOBEC3B expression in 293T viral producer cells drives mutations in chimeric antigen receptors and reduces CAR T cell efficacy., PMID:39403625
p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver., PMID:39346550
Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs., PMID:39322638
Genetic alteration of mRNA editing enzyme APOBEC3B in the pathogenesis of ovarian endometriosis., PMID:39197402
RAD51 protects abasic sites to prevent replication fork breakage., PMID:39178838
Regulation, functional impact, and therapeutic targeting of APOBEC3A in cancer., PMID:39047499
The role of distinct APOBEC/ADAR mRNA levels in mutational signatures linked to aging and ultraviolet radiation., PMID:38965255
The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences., PMID:38946641
APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution., PMID:38868014
New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B., PMID:38827321
Development of Allosteric Small Molecule APOBEC3B Inhibitors from In Silico Screening., PMID:38712210
Protein Interaction Map of APOBEC3 Enzyme Family Reveals Deamination-Independent Role in Cellular Function., PMID:38548018
Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations., PMID:38499553
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes., PMID:38499542
Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function., PMID:38370690
Monitoring APOBEC3A protein levels in human cancer cells., PMID:38359985
Role and molecular mechanism of APOBEC3B in the development and progression of gastric cancer., PMID:38312680
The Mutational Spectrum of Pre- and Post-Neoadjuvant Chemotherapy Triple-Negative Breast Cancers., PMID:38254917
Computational drug discovery of an inhibitor of APOBEC3B as a treatment for epithelial cancers., PMID:38109103
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance., PMID:38049664
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer., PMID:38033156
Acute expression of human APOBEC3B in mice results in RNA editing and lethality., PMID:38001542
[SWI/SNF Complex Gene Mutations Promote the Liver Metastasis
of Non-small Cell Lung Cancer Cells in NSI Mice]., PMID:37989338
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases., PMID:37797615
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer., PMID:37735199
APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels., PMID:37672599
Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations., PMID:37577595
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism., PMID:37565748
For research use only. Not for human or drug use.
