Catalog No.
YHJ74301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn472-Val652
Predicted molecular weight
22.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBZ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA repair protein REV1, AIBP80, Alpha integrin-binding protein 80, REV1L, Rev1-like terminal deoxycytidyl transferase, REV1
Tumor-associated macrophages contribute to cisplatin resistance via regulating Pol η-mediated translesion DNA synthesis in ovarian cancer., PMID:40437303
Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing., PMID:40166206
Comparative Transcriptome Analysis of Arabidopsis Seedlings Under Heat Stress on Whole Plants, Shoots, and Roots Reveals New HS-Regulated Genes, Organ-Specific Responses, and Shoots-Roots Communication., PMID:40141121
Post-replicative lesion processing limits DNA damage-induced mutagenesis., PMID:40114379
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed., PMID:40106439
FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations., PMID:40082407
Bypass of Methoxyamine-Adducted Abasic Sites by Eukaryotic Translesion DNA Polymerases., PMID:39859356
Molecular dependencies and genomic consequences of a global DNA damage tolerance defect., PMID:39741332
PCNA and Rnh1 independently participate in the protection of mitochondrial genome against UV-induced mutagenesis in yeast cells., PMID:39730600
DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion., PMID:39727171
The putative error prone polymerase REV1 mediates DNA damage and drug resistance in Candida albicans., PMID:39619432
Disruption of Erythritol Catabolism via the Deletion of Fructose-Bisphosphate Aldolase (Fba) and Transaldolase (Tal) as a Strategy to Improve the Brucella Rev1 Vaccine., PMID:39457012
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis., PMID:39300172
Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671
REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster., PMID:39074150
Protein Assemblies in Translesion Synthesis., PMID:39062611
PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis., PMID:39043663
Whole Genome Sequence Analysis of Brucella spp. from Human, Livestock, and Wildlife in South Africa., PMID:39037482
Loss-of-function mutation of REV1 (p.R704Q) mediates cetuximab primary resistance by activating autophagy in RAS-wild type metastatic colorectal cancer., PMID:38969162
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases., PMID:38959714
The effect of exogenous melatonin on waterlogging stress in Clematis., PMID:38957603
MRNIP limits ssDNA gaps during replication stress., PMID:38917325
Phylogenetic Analysis and Comparative Genomics of Brucella abortus and Brucella melitensis Strains in Egypt., PMID:38809331
Rev1Δwzm vaccine candidate is safe in young and adult sheep and protects against Brucella ovis infection in rams., PMID:38806353
USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase., PMID:38802791
Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction., PMID:38749343
Cryo-EM structure of the Rev1-Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis., PMID:38720088
Primordial germ cell DNA demethylation and development require DNA translesion synthesis., PMID:38702312
The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA., PMID:38612916
Rev1 overexpression accelerates N-methyl-N-nitrosourea (MNU)-induced thymic lymphoma by increasing mutagenesis., PMID:38572512
WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases., PMID:38503516
REV1 Coordinates a Multi-Faceted Tolerance Response to DNA Alkylation Damage and Prevents Chromosome Shattering in Drosophila melanogaster., PMID:38405884
The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links., PMID:38352618
The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage., PMID:38321962
PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass., PMID:37971291
A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases., PMID:37935254
Mad2B forms a complex with Cdc20, Cdc27, Rev3 and Rev1 in response to cisplatin-induced DNA damage., PMID:37641805
Mitochondrial superoxide dismutase Sod2 suppresses nuclear genome instability during oxidative stress., PMID:37638880
Two independent DNA repair pathways cause mutagenesis in template switching deficient Saccharomyces cerevisiae., PMID:37594077
Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating AhR-TLS-promoted genomic instability in human colon cancer cells., PMID:37543059
Genetic inhibitors of APOBEC3B-induced mutagenesis., PMID:37532520
The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG-related disorders., PMID:37470284
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells., PMID:37459543
Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis., PMID:37415867
Episomal and chromosomal DNA replication and recombination in Entamoeba histolytica., PMID:37363402
A novel role for Mms2 in the control of spontaneous mutagenesis and Pol3 abundance., PMID:36934633
Mammalian life depends on two distinct pathways of DNA damage tolerance., PMID:36669105
Vaccine properties of Brucella melitensis 16MΔwzm and reactivation of placental infection in pregnant sheep., PMID:36653223
Evaluation of the goat cellular immune response to rBtuB-Hia-FlgK peptides from Brucella melitensis., PMID:36638645
Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ., PMID:36592930
For research use only. Not for human or drug use.
