Catalog No.
YHJ70501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala331-Tyr503
Predicted molecular weight
21.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZW5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MPP6, VAM1, Veli-associated MAGUK 1, MAGUK p55 subfamily member 6, VAM-1
Involvement of membrane palmitoylated protein 6 (MPP6) in synapses of mouse cerebrum., PMID:40360818
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy., PMID:38565536
A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor., PMID:38000659
Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families., PMID:37895291
Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs., PMID:37672187
Key genes and potential drugs in age-related hearing loss: transcriptome analysis of cochlear hair cells in old mice., PMID:37605587
A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor., PMID:37292674
Elevated MPP6 expression correlates with an unfavorable prognosis, angiogenesis and immune evasion in hepatocellular carcinoma., PMID:37207207
MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus., PMID:35902094
Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus., PMID:35854144
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex., PMID:35688134
Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35., PMID:35445918
Genetic parameters estimation and genome-wide association studies for internal organ traits in an F2 chicken population., PMID:35225379
Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination., PMID:34450044
Synthesis and Cellular Labeling of Multifunctional Phosphatidylinositol Bis- and Trisphosphate Derivatives., PMID:34075669
Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons., PMID:33034629
The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis., PMID:32003502
Reconstitution of the Human Nuclear RNA Exosome., PMID:31768991
Reconstitution of the Schizosaccharomyces pombe RNA Exosome., PMID:31768990
Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins., PMID:31768989
Structures and Molecular Composition of Schmidt-Lanterman Incisures., PMID:31760645
Scaffold protein Lin7 family in membrane skeletal protein complex in mouse seminiferous tubules., PMID:31410570
Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression., PMID:31402947
The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system., PMID:30357511
Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex., PMID:29906447
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors., PMID:29351990
Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase., PMID:28877463
Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system., PMID:28755316
Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase., PMID:28742025
Exosome Cofactors Connect Transcription Termination to RNA Processing by Guiding Terminated Transcripts to the Appropriate Exonuclease within the Nuclear Exosome., PMID:27076633
Involvement of membrane skeletal molecules in the Schmidt-Lanterman incisure in Schwann cells., PMID:26541343
Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine., PMID:26496923
Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells., PMID:26295306
NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing., PMID:26166824
The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase., PMID:25319414
The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae., PMID:24224060
Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6., PMID:24106327
Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast., PMID:24047896
Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS., PMID:23306908
Molecular cloning and mRNA expression of M-phase phosphoprotein 6 gene in black tiger shrimp (Penaeus monodon)., PMID:23065290
Comparison of the yeast and human nuclear exosome complexes., PMID:22817747
Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves., PMID:22025680
Rrp6, rrp47 and cofactors of the nuclear exosome., PMID:21713680
Anti-degradation of a recombinant complex protein by incorporation in small molecular hydrogels., PMID:21079842
Rrp6, Rrp47 and cofactors of the nuclear exosome., PMID:21618877
A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts., PMID:18591258
C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome., PMID:17599775
C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing., PMID:17412707
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation., PMID:16396833
A protein interaction framework for human mRNA degradation., PMID:15231747
For research use only. Not for human or drug use.
