Catalog No.
YHJ67301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln81
Predicted molecular weight
11.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NSA3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Inhibitor of beta-catenin and Tcf-4, ICAT, Beta-catenin-interacting protein 1, CTNNBIP1
Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1., PMID:38811444
Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease., PMID:38404150
Paeoniflorin inhibits colorectal cancer cell stemness through the miR-3194-5p/catenin beta-interacting protein 1 axis., PMID:37530655
miR-342-5p targets CTNNBIP1 to promote enterovirus 71 replication., PMID:37479047
LINC00355 Mediates CTNNBIP1 Promoter Methylation and Promotes Endoplasmic Reticulum Stress-Induced Podocyte Injury in Diabetic Nephropathy., PMID:36738224
Verification of Ferroptosis Subcluster-Associated Genes Related to Osteosarcoma and Exploration of Immune Targeted Therapy., PMID:36211822
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice., PMID:36181623
ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway., PMID:36036768
Expression level and prognostic potential of beta-catenin-interacting protein in acute myeloid leukemia., PMID:35984200
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models., PMID:35536676
DNA methylation signatures in Blood DNA of Hutchinson-Gilford Progeria syndrome., PMID:35045206
RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma., PMID:34975322
miR-29a-3p promotes migration and invasion in ameloblastoma via Wnt/β-catenin signaling by targeting catenin beta interacting protein 1., PMID:34636093
Overexpression of ICAT Inhibits the Progression of Colorectal Cancer by Binding with β-Catenin in the Cytoplasm., PMID:34569368
Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function., PMID:34320339
The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development., PMID:34192541
MiR-486-3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/β-catenin pathway., PMID:34118593
The Circ_CARM1 controls cell migration by regulating CTNNBIP1 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells., PMID:34052308
ICAT acts as a Coactivator in Regulating PPARγ Transcriptional Activity in Mesangial Cells., PMID:32937668
CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of β-catenin/TCF complex downstream genes., PMID:32531088
E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT., PMID:32326181
miR‑296‑3p promotes the proliferation of glioblastoma cells by targeting ICAT., PMID:32323769
The Alteration of CTNNBIP1 in Lung Cancer., PMID:31766223
Spatial sorting enables comprehensive characterization of liver zonation., PMID:31535084
Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma., PMID:31432149
Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/β-catenin pathway inactivation through ICAT., PMID:31207322
Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells., PMID:30957640
A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes., PMID:30590765
CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway., PMID:30424816
Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction., PMID:30197296
CTNNBIP1 downregulation is associated with tumor grade and viral infections in gastric adenocarcinoma., PMID:30076728
Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner., PMID:29540185
Integrated analysis of long noncoding RNA-associated competing endogenous RNA network in periodontitis., PMID:29516510
Ibuprofen reduces cell proliferation through inhibiting Wnt/β catenin signaling pathway in gastric cancer stem cells., PMID:29512256
Inhibitor of β-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/β-catenin complex., PMID:29048651
Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling., PMID:28939743
Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity., PMID:28273108
Müllerian inhibiting substance inhibits an ovarian cancer cell line via β-catenin interacting protein deregulation of the Wnt signal pathway., PMID:28197641
Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids., PMID:28092415
CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma., PMID:27829235
[Overexpression of inhibitor of β-catenin and T cell factor (ICAT) promotes proliferation and migration of cervical cancer Caski cells]., PMID:27774943
MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1., PMID:27521659
Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance., PMID:27208794
[Expression of ICAT and Wnt signaling-related proteins in the monocytic differentiation of HL-60 cells induced by a new steroidal drug NSC67657]., PMID:27087369
MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway., PMID:26337084
MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma., PMID:26317904
Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas., PMID:26299367
MicroRNAs 29b, 133b, and 211 Regulate Vascular Smooth Muscle Calcification Mediated by High Phosphorus., PMID:26187577
Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis., PMID:25760378
miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1., PMID:25681036
For research use only. Not for human or drug use.
