Catalog No.
YHJ66801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr125
Predicted molecular weight
16.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRX4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein histidine phosphatase, Protein janus-A homolog, PHPT1, PHP14, 14 kDa phosphohistidine phosphatase, PHP, Phosphohistidine phosphatase 1
Histidine Phosphorylation: Protein Kinases and Phosphatases., PMID:39063217
[Progress in enrichment methods for protein N-phosphorylation]., PMID:38966971
A salt bridge of the C-terminal carboxyl group regulates PHPT1 substrate affinity and catalytic activity., PMID:38747379
Genetic associations of protein-coding variants in venous thromboembolism., PMID:38561338
Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1., PMID:37267298
Identification of a Target Site for Covalent Inhibition of Protein Phosphohistidine Phosphatase 1., PMID:36518699
Histidine dephosphorylation of the Gβ protein GPB-1 promotes axon regeneration in C. elegans., PMID:36278516
Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1., PMID:35859860
Comparative transcriptomic analysis reveals region-specific expression patterns in different beef cuts., PMID:35596128
FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer., PMID:35411430
Identification of Hub Genes Associated With Tuberculous Pleurisy by Integrated Bioinformatics Analysis., PMID:34925441
14-kDa phosphohistidine phosphatase is a potential therapeutic target for liver fibrosis., PMID:33406007
Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl4-induced liver fibrosis., PMID:32860079
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer., PMID:32186702
Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling., PMID:32027948
Roles of Protein Histidine Phosphatase 1 (PHPT1) in Brown Adipocyte Differentiation., PMID:31752058
In Vitro Assays for Measuring Protein Histidine Phosphatase Activity., PMID:31707655
Protein Phosphohistidine Phosphatases of the HP Superfamily., PMID:31707654
RAPID GENE EXPRESSION BASED DOSE ESTIMATION FOR RADIOLOGICAL EMERGENCIES., PMID:31137037
Specific Fluorescent Probe for Protein Histidine Phosphatase Activity., PMID:30912641
Influence of Confounding Factors on Radiation Dose Estimation Using In Vivo Validated Transcriptional Biomarkers., PMID:29787434
Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity., PMID:29630837
Regulation of KATP Channel Trafficking in Pancreatic β-Cells by Protein Histidine Phosphorylation., PMID:29440278
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway., PMID:29098317
pHisphorylation: the emergence of histidine phosphorylation as a reversible regulatory modification., PMID:28129587
Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells., PMID:27974694
Structural and activity characterization of human PHPT1 after oxidative modification., PMID:27034094
Chemical Synthesis of Proteins with Non-Strategically Placed Cysteines Using Selenazolidine and Selective Deselenization., PMID:26636774
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma., PMID:26537769
Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine., PMID:25574816
A splice variant of the human phosphohistidine phosphatase 1 (PHPT1) is degraded by the proteasome., PMID:25450458
Regulation of the epithelial Ca²⁺ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1., PMID:24523290
[Study on gene differential expressions of substance and energy metabolism in chronic superficial gastritis patients of Pi deficiency syndrome and of pi-wei hygropyrexia syndrome]., PMID:23185754
Design and synthesis of an Fmoc-SPPS-compatible amino acid building block mimicking the transition state of phosphohistidine phosphatase., PMID:22283371
Histone H4 histidine phosphorylation: kinases, phosphatases, liver regeneration and cancer., PMID:22260708
Influence of protein histidine phosphatase overexpression and down-regulation on human umbilical-vein endothelial cell viability., PMID:21967643
MALDI-TOF high mass calibration up to 200 kDa using human recombinant 16 kDa protein histidine phosphatase aggregates., PMID:21876758
A screening method for phosphohistidine phosphatase 1 activity., PMID:21679093
Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion., PMID:21626002
Clinical significance of PHPT1 protein expression in lung cancer., PMID:21163124
Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1., PMID:20946858
Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells., PMID:20501872
Relevance of glycine and cysteine residues as well as N- and C-terminals for the activity of protein histidine phosphatase., PMID:19836470
Immunohistochemical localization of phosphohistidine phosphatase PHPT1 in mouse and human tissues., PMID:19396692
Ethylene regulates phosphorus remobilization and expression of a phosphate transporter (PhPT1) during petunia corolla senescence., PMID:19380421
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion., PMID:19344975
Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand., PMID:19320245
Reversible phosphorylation of histidine residues in proteins from vertebrates., PMID:19278958
Role of protein histidine phosphatase for viability of neuronal cells., PMID:19138678
Solution structure and catalytic mechanism of human protein histidine phosphatase 1., PMID:18991813
For research use only. Not for human or drug use.
