Catalog No.
YHJ66601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His353-Ser550
Predicted molecular weight
49.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRR4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein Drosha, DROSHA, Ribonuclease III, RNASE3L, RNASEN, RN3, RNase III, Ribonuclease 3, p241
PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor., PMID:40512079
[Berberine promotes expression of AQP4 in astrocytes by regulating production of miR-383-5p in HepG2 cell-derived exosomes under insulin resistance]., PMID:40350853
Sex-Biased Gene Expression of RNAi Pathway Components in the Sea Lice Caligus rogercresseyi., PMID:40347394
Drosha: a new tumor suppressor in pineoblastoma., PMID:40345854
Characteristics of the MicroRNA-Processing Enzymes in Melanocytic Skin Lesions: Dicer and DGCR8 Are Potential Biomarkers for Primary Cutaneous Melanomas., PMID:40344283
Assessing Microprocessor Complex Mutations with a Microsensor System., PMID:40328469
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma., PMID:40240142
Dysregulation of MicroRNA Biogenesis Machinery in Nervous System Diseases., PMID:40082738
D-bait: A siDNA for regulation of DNA-protein kinases against DNA damage and its implications in cancer., PMID:40024452
Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition., PMID:39992227
The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers., PMID:39970212
miR-32533 Reduces Cognitive Impairment and Amyloid-β Overload by Targeting CREB5-Mediated Signaling Pathways in Alzheimer's Disease., PMID:39840513
The biogenesis and regulation of animal microRNAs., PMID:39702526
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor., PMID:39677784
Genetics architecture of spontaneous coronary artery dissection in an Italian cohort., PMID:39654947
PIWIL genes in hepatocellular carcinoma: a multi-omics approach uncovering dysregulated expression and ceRNA networks in mice., PMID:39604866
MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?, PMID:39601261
Relationship Between the Occurrence of Depression and DROSHA (rs6877842, rs10719) and XPO5 (rs11077) Single-Nucleotide Polymorphisms in the Polish Population: A Case-Control Study., PMID:39596271
A functional connection between the Microprocessor and a variant NEXT complex., PMID:39515294
Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8., PMID:39464105
MicroRNA and Rare Human Diseases., PMID:39457367
BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseases., PMID:39455000
AGO2 protein: a key enzyme in the miRNA pathway as a novel biomarker in adrenocortical carcinoma., PMID:39404265
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs., PMID:39368465
TET proteins regulate Drosha expression and impact microRNAs in iNKT cells., PMID:39364402
A transcription-independent role for HIF-1α in modulating microprocessor assembly., PMID:39319577
Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ., PMID:39250314
ARGONAUTE2 Localizes to Sites of Sporocysts in the Schistosome-Infected Snail, Biomphalaria glabrata., PMID:39202383
Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma., PMID:39196622
TET proteins regulate Drosha expression and impact microRNAs in iNKT cells., PMID:39131272
IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration., PMID:39102262
IL-32 regulates trophoblast invasion through miR-205-NFκB-MMP2/9 axis contributing to the pregnancy-induced hypertension†., PMID:39101465
The Effect of Alternative Splicing Sites on Mirtron Formation and Arm Selection of Precursor microRNAs., PMID:39062888
The double-stranded microRNA precursor., PMID:39016229
CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth., PMID:39003349
m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis., PMID:38879605
Extended haplotype with rs41524547-G defines the ancestral origin of SCA10., PMID:38832639
Structural basis of pri-let-7 recognition by human pseudouridine synthase TruB1., PMID:38776834
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA., PMID:38722021
Regulation of Microprocessor assembly and localization via Pasha's WW domain in C. elegans., PMID:38712061
DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor., PMID:38647377
Regulatory role of RNA-binding proteins in microRNA biogenesis., PMID:38567098
Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression., PMID:38545619
Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism., PMID:38517158
Non-canonical RNA substrates of Drosha lack many of the conserved features found in primary microRNA stem-loops., PMID:38509178
Variant Analysis of miRNA Regulatory Genes in 35 Sporadic Lung Carcinoma Tumors., PMID:38472669
Effect of heat stress on the hypothalamic expression of water channel- and noncoding RNA biogenesis-related genes in modern broilers and their ancestor red jungle fowl., PMID:38365130
Cytoplasmic and nuclear DROSHA in human villous trophoblasts., PMID:38241848
Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI., PMID:38200156
Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs., PMID:38109320
For research use only. Not for human or drug use.
