Catalog No.
YHJ66601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His353-Ser550
Predicted molecular weight
49.81 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRR4
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein Drosha, DROSHA, Ribonuclease III, RNASE3L, RNASEN, RN3, RNase III, Ribonuclease 3, p241
Note
For research use only.
Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs., PMID:38109320
Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI., PMID:38200156
Cytoplasmic and nuclear DROSHA in human villous trophoblasts., PMID:38241848
Effect of heat stress on the hypothalamic expression of water channel- and noncoding RNA biogenesis-related genes in modern broilers and their ancestor red jungle fowl., PMID:38365130
Variant Analysis of miRNA Regulatory Genes in 35 Sporadic Lung Carcinoma Tumors., PMID:38472669
Non-canonical RNA substrates of Drosha lack many of the conserved features found in primary microRNA stem-loops., PMID:38509178
Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism., PMID:38517158
Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression., PMID:38545619
Regulatory role of RNA-binding proteins in microRNA biogenesis., PMID:38567098
DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor., PMID:38647377
Regulation of Microprocessor assembly and localization via Pasha's WW domain in C. elegans., PMID:38712061
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA., PMID:38722021
Structural basis of pri-let-7 recognition by human pseudouridine synthase TruB1., PMID:38776834
Extended haplotype with rs41524547-G defines the ancestral origin of SCA10., PMID:38832639
m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis., PMID:38879605
CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth., PMID:39003349
The double-stranded microRNA precursor., PMID:39016229
The Effect of Alternative Splicing Sites on Mirtron Formation and Arm Selection of Precursor microRNAs., PMID:39062888
IL-32 regulates trophoblast invasion through miR-205-NFκB-MMP2/9 axis contributing to the pregnancy-induced hypertension†., PMID:39101465
IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration., PMID:39102262
TET proteins regulate Drosha expression and impact microRNAs in iNKT cells., PMID:39131272
Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma., PMID:39196622
ARGONAUTE2 Localizes to Sites of Sporocysts in the Schistosome-Infected Snail, Biomphalaria glabrata., PMID:39202383
Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ., PMID:39250314
A transcription-independent role for HIF-1α in modulating microprocessor assembly., PMID:39319577
TET proteins regulate Drosha expression and impact microRNAs in iNKT cells., PMID:39364402
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs., PMID:39368465
AGO2 protein: a key enzyme in the miRNA pathway as a novel biomarker in adrenocortical carcinoma., PMID:39404265
BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseases., PMID:39455000
MicroRNA and Rare Human Diseases., PMID:39457367
Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8., PMID:39464105
A functional connection between the Microprocessor and a variant NEXT complex., PMID:39515294
Relationship Between the Occurrence of Depression and DROSHA (rs6877842, rs10719) and XPO5 (rs11077) Single-Nucleotide Polymorphisms in the Polish Population: A Case-Control Study., PMID:39596271
MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?, PMID:39601261
PIWIL genes in hepatocellular carcinoma: a multi-omics approach uncovering dysregulated expression and ceRNA networks in mice., PMID:39604866
Genetics architecture of spontaneous coronary artery dissection in an Italian cohort., PMID:39654947
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor., PMID:39677784
The biogenesis and regulation of animal microRNAs., PMID:39702526
miR-32533 Reduces Cognitive Impairment and Amyloid-β Overload by Targeting CREB5-Mediated Signaling Pathways in Alzheimer's Disease., PMID:39840513
The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers., PMID:39970212
Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition., PMID:39992227
D-bait: A siDNA for regulation of DNA-protein kinases against DNA damage and its implications in cancer., PMID:40024452
Dysregulation of MicroRNA Biogenesis Machinery in Nervous System Diseases., PMID:40082738
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma., PMID:40240142
Assessing Microprocessor Complex Mutations with a Microsensor System., PMID:40328469
Characteristics of the MicroRNA-Processing Enzymes in Melanocytic Skin Lesions: Dicer and DGCR8 Are Potential Biomarkers for Primary Cutaneous Melanomas., PMID:40344283
Drosha: a new tumor suppressor in pineoblastoma., PMID:40345854
Sex-Biased Gene Expression of RNAi Pathway Components in the Sea Lice Caligus rogercresseyi., PMID:40347394
[Berberine promotes expression of AQP4 in astrocytes by regulating production of miR-383-5p in HepG2 cell-derived exosomes under insulin resistance]., PMID:40350853
PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor., PMID:40512079
For research use only. Not for human or drug use.
