Catalog No.
YHJ66001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser102-Cys261
Predicted molecular weight
18.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRI5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0457, Disrupted in schizophrenia 1 protein, DISC1
Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses., PMID:40503182
A peptide mimetic therapeutic strategy targeting dysfunction of the scaffold protein DISC-1 in psychiatric disorders., PMID:40449672
Meta-analysis of the diagnostic value of SOX1 methylation in different types of cervical cancer., PMID:40259371
Long-term treatment with haloperidol modulates angiotensin I-converting enzyme (ACE) activity in transgenic animal model with construct validity for schizophrenia studies., PMID:40228572
Lithium attenuates ketamine-induced long-term neurotoxicity through DISC1-mediated GSK-3β/β-catenin and ERK/CREB pathways., PMID:40024338
3-Dimensional structure prediction of C-terminal disrupted in schizophrenia 1: a suspected culprit of schizophrenia., PMID:39987524
Corrigendum: Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1., PMID:39839352
Identification of ARHGEF11 (PDZ-RhoGEF) as an in vivo regulator of synapses and cognition., PMID:39835891
FMR1 genetically interacts with DISC1 to regulate glutamatergic synaptogenesis., PMID:39604386
BMAL1-Potential Player of Aberrant Stress Response in Q31L Mice Model of Affective Disorders: Pilot Results., PMID:39596543
Dexmedetomidine Alleviates the Long-Term Neurodevelopmental Toxicity Induced by Sevoflurane in the Developing Brain., PMID:39433029
Impact of feeding age on cognitive impairment in mice with Disrupted-In-Schizophrenia 1 (Disc1) mutation under a high sucrose diet., PMID:39401692
Transgenic Drosophila melanogaster Carrying a Human Full-Length DISC1 Construct (UAS-hflDISC1) Showing Effects on Social Interaction Networks., PMID:39194719
SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus., PMID:38960088
The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing., PMID:38934920
Structural Variants and Implicated Processes Associated with Familial Tourette Syndrome., PMID:38891944
Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3β interaction., PMID:38840775
Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia., PMID:38648100
Astrocyte-mediated regulation of BLAWFS1 neurons alleviates risk-assessment deficits in DISC1-N mice., PMID:38642554
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia., PMID:38552722
Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons., PMID:38438989
Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia., PMID:38320995
The serum small non-coding RNA (SncRNA) landscape as a molecular biomarker of age associated muscle dysregulation and insulin resistance in older adults., PMID:38294260
Evidence of DISC1 as an arsenic binding protein and implications regarding its role as a translational activator., PMID:38192336
Association Between Wnt Target Genes and Cortical Volumes in Alzheimer's Disease., PMID:38135866
Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the protein., PMID:38135095
TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids., PMID:38129659
DISC1 protein aggregates in cerebrospinal fluid as a potential diagnostic biomarker for first-episode psychosis., PMID:37964686
Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function., PMID:37830916
Meta-analysis of the applied value of the growth differentiation factor 15 detection in HFpEF diagnosis., PMID:37811648
Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis., PMID:37668563
Diagnostic accuracy of MUC7 expression for bladder cancer: A systematic review and meta-analysis., PMID:37657056
Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes., PMID:37542622
Co-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness., PMID:37508512
Evidence of Disrupted-in Schizophrenia 1 (DISC1) as an arsenic binding protein and implications regarding its role as a translational activator., PMID:37398111
Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m6 modification., PMID:37340635
50-kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats., PMID:37016810
GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia., PMID:37004850
Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study., PMID:36858606
Layer-specific impairment in the developing lateral entorhinal cortex of immune-challenged Disc1+/- mice., PMID:36647326
Diffusion radiomics for subtyping and clustering in autism spectrum disorder: A preclinical study., PMID:36496097
Methylation pattern and mRNA expression of synapse-relevant genes in the MAM model of schizophrenia in the time-course of adolescence., PMID:36481661
Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders., PMID:36430976
Electroacupuncture improves cognitive impairment in diabetic cognitive dysfunction rats by regulating the mitochondrial autophagy pathway., PMID:36418941
The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population., PMID:36397361
The mechanism of acentrosomal spindle assembly in human oocytes., PMID:36395215
Genetic polymorphism and neuroanatomical changes in schizophrenia., PMID:36374137
Disrupted-in-schizophrenia-1 is required for normal pyramidal cell-interneuron communication and assembly dynamics in the prefrontal cortex., PMID:36239988
TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein., PMID:36232351
Generation of two induced pluripotent stem cell lines (TMOi001-A-5, TMOi001-A-6) carrying variants in DISC1 exon 2 using CRISPR/Cas9 gene editing., PMID:36154917
For research use only. Not for human or drug use.
