Catalog No.
YHJ65001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg4576-Leu4857
Predicted molecular weight
34.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NR09
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1289, BIRC6, BRUCE, RING-type E3 ubiquitin transferase BIRC6, BIR repeat-containing ubiquitin-conjugating enzyme, APOLLON, Baculoviral IAP repeat-containing protein 6, Ubiquitin-conjugating BIR domain enzyme apollon
Immunohistochemical Expression of Baculoviral Inhibitor of Apoptotic Proteins Repeat-Containing Protein in Tumors of Salivary Gland Origin., PMID:40510224
TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases., PMID:40274822
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin., PMID:40208944
The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A., PMID:39705142
CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1., PMID:39258752
T-reg transcriptomic signatures identify response to check-point inhibitors., PMID:38710724
Circ_100549 promotes tumor progression in lung adenocarcinoma through upregulation of BIRC6., PMID:38613646
CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer., PMID:38438090
BIRC6 Modulates the Protein Stability of Axin to Regulate the Growth, Stemness, and Resistance of Renal Cancer Cells via the β-Catenin Pathway., PMID:38405482
Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy., PMID:38291026
Chuanzhitongluo Inhibits Neuronal Apoptosis in Mice with Acute Ischemic Stroke by Regulating the PI3K/AKT Signaling Pathway., PMID:38040086
Comprehensive analysis of prognostic value and immune infiltration of IAPs family in hepatocellular carcinoma., PMID:37781078
A massive machine regulates cell death., PMID:36927032
A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response., PMID:36855916
Influence of Perinatal Factors on Gene Expression of IAPs Family and Main Factors of Pluripotency: OCT4 and SOX2 in Human Breast Milk Stem Cells-A Preliminary Report., PMID:36768802
Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6., PMID:36758106
Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex., PMID:36758105
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases., PMID:36758104
lncRNA LINC00960 promotes apoptosis by sponging ubiquitin ligase Nrdp1-targeting miR-183-5p., PMID:36722261
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas., PMID:36576405
Indolent T-cell lymphoproliferative disorder of gastrointestinal tract with unusual clinical courses: report of 6 cases and literature review., PMID:36472661
Exploring the Role of the Inhibitor of Apoptosis BIRC6 in Breast Cancer: A Database Analysis., PMID:36455174
Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation., PMID:36200270
Interleukin-4 receptor alpha signaling regulates monocyte homeostasis., PMID:36063138
Oral Squamous Cell Carcinoma: The Role of BIRC6 Serum Level., PMID:36033570
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment., PMID:35964136
BIRC6 modifies risk of invasive bacterial infection in Kenyan children., PMID:35866869
A new circular RNA-encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)-induced mitochondrial dysfunction., PMID:35863430
circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis., PMID:35191420
Comprehensive Analysis of Inhibitor of Apoptosis Protein Expression and Prognostic Significance in Non-Small Cell Lung Cancer., PMID:34925455
Five crucial prognostic-related autophagy genes stratified female breast cancer patients aged 40-60 years., PMID:34876005
[Effect of circBIRC6 targeting miR-367-3p on cisplatin resistance of ovarian cancer cells]., PMID:34695896
Copy number variations in a Brazilian cohort with autism spectrum disorders highlight the contribution of cell adhesion genes., PMID:34664255
A Pan-Cancer Analysis of the BIRC Gene Family and Its Association with Prognosis, Tumor Microenvironment, and Therapeutic Targets., PMID:34587434
Silencing circ‑BIRC6 inhibits the proliferation, invasion, migration and epithelial‑mesenchymal transition of bladder cancer cells by targeting the miR‑495‑3p/XBP1 signaling axis., PMID:34542161
Inhibitors of apoptosis: expression and regulation in the endometrium during the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs., PMID:34530503
BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease., PMID:34354038
Detection of Rare Germline Variants in the Genomes of Patients with B-Cell Neoplasms., PMID:33809641
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity., PMID:33577797
BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque., PMID:33317170
[Effect of small interfering RNA-mediated BIRC6 silencing on apoptosis and autophagy of renal cancer 786-O cells]., PMID:33243730
Depletion of circ-BIRC6, a circular RNA, suppresses non-small cell lung cancer progression by targeting miR-4491., PMID:33177288
Paclitaxel Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating Circ-BIRC6/miR-877-5p/YWHAZ Axis., PMID:33061425
A novel EML4-ALK BIRC6-ALK double fusion variant in lung adenocarcinoma confers sensitivity to alectinib., PMID:32409002
The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?, PMID:32255730
BRUCE preserves genomic stability in the male germline of mice., PMID:32139899
Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE., PMID:32019552
Analysis of the expression of BAX, BCL2, BIRC6, CASP3, CASP9 apoptosis genes during the first episode of schizophrenia., PMID:32017818
Expression of inhibitors of apoptosis proteins in salivary gland adenoid cystic carcinoma: XIAP is an independent marker of impaired cause-specific survival., PMID:31984681
Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer., PMID:31964418
For research use only. Not for human or drug use.
