Catalog No.
YHJ62201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser24-Ala126
Predicted molecular weight
37.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NP84
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FGF-inducible 14, TNFRSF12A, FN14, CD266, TweakR, Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, Tumor necrosis factor receptor superfamily member 12A
TNFRSF12A expression in stomach adenocarcinoma and its preliminary role in predicting immunotherapy response., PMID:40391219
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma., PMID:39833632
TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages., PMID:39827460
Tumour necrosis factor-like weak inducer of apoptosis participates in the development of cutaneous fibrosis in an experimental systemic sclerosis model., PMID:39713893
Expression of TWEAK/Fn14 axis in the context of metabolic dysfunction associated-fatty liver disease: an approach in liver regeneration., PMID:39538394
TWEAK is an activator of Hippo-YAP signaling protecting against hepatic Ischemia/ reperfusion injury., PMID:39500083
Proposed Hypothesis of TWEAK/Fn14 Receptor Modulation in Autism Spectrum Disorder., PMID:39473248
TWEAK increases angiogenesis to promote diabetic skin wound healing by regulating Fn14/EGFR signaling., PMID:39166480
The Oncogenic Role of TNFRSF12A in Colorectal Cancer and Pan-Cancer Bioinformatics Analysis., PMID:39118523
TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer., PMID:38965263
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma., PMID:38582787
Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis., PMID:38277520
Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia., PMID:37761958
TWEAK promotes inflammatory response in liver fibrosis., PMID:37503908
Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer., PMID:37060824
Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands., PMID:36338147
TWEAK-Fn14 Axis Induces Calcium-Associated Autophagy and Cell Death To Control Mycobacterial Survival in Macrophages., PMID:36321903
Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative., PMID:35163208
The TWEAK/Fn14/CD163 axis-implications for metabolic disease., PMID:34542797
BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells., PMID:34517088
ThPOK transcriptionally inactivates TNFRSF12A to increase the proliferation of T cells with the involvement of the NF-kB pathway., PMID:34353698
Deciphering Mesenchymal Drivers of Human Dupuytren's Disease at Single-Cell Level., PMID:34274346
TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease., PMID:34155062
Elevated fibroblast growth factor-inducible 14 expression transforms proneural-like gliomas into more aggressive and lethal brain cancer., PMID:33991013
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids., PMID:33238290
The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19., PMID:32979900
Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B., PMID:32958685
The Diagnostic Value of sTWEAK in Acute Ischemic Stroke., PMID:32856885
Decreased expression of TNFRSF12A in thyroid gland cancer predicts poor prognosis: A study based on TCGA data., PMID:32846846
Testosterone supplementation upregulates androgen receptor expression and translational capacity during severe energy deficit., PMID:32776828
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson's Disease., PMID:32759670
The mechanism of Chinese herbal formula HQT in the treatment of rheumatoid arthritis is related to its regulation of lncRNA uc.477 and miR-19b., PMID:32696503
TWEAK/Fn14 axis in respiratory diseases., PMID:32526219
Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF-κB) pathway., PMID:32225128
Controversies in TWEAK-Fn14 signaling in skeletal muscle atrophy and regeneration., PMID:32200423
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK)/Fibroblast Growth Factor-Inducible 14 (Fn14) Axis in Cardiovascular Diseases: Progress and Challenges., PMID:32053869
Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer., PMID:31998833
Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures., PMID:31964950
Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis., PMID:31885495
A single molecule assay for ultrasensitive detection of Fn14 in human serum., PMID:31580829
The effect of APTR, Fn14 and CD133 expressions on liver fibrosis in biliary atresia patients., PMID:31549181
Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness., PMID:31500625
A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis., PMID:31395500
Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells., PMID:31393695
TWEAK/Fn14 Is Overexpressed in Crohn's Disease and Mediates Experimental Ileitis by Regulating Critical Innate and Adaptive Immune Pathways., PMID:31181286
Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation., PMID:31023317
TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma., PMID:30414907
Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins., PMID:30218067
High TNFRSF12A level associated with MMP-9 overexpression is linked to poor prognosis in breast cancer: Gene set enrichment analysis and validation in large-scale cohorts., PMID:30142200
CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling., PMID:30065029
For research use only. Not for human or drug use.
