Catalog No.
YHJ60001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His260-Arg409
Predicted molecular weight
19.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HBX9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LGR7, Relaxin family peptide receptor 1, Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, RXFP1
The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists., PMID:40434342
G-Protein-Coupled Receptors in Chronic Kidney Disease Induced by Hypertension and Diabetes., PMID:40422232
Circularized Supramolecular Spherical Nucleic Acids Alleviates Liver Fibrosis through Blocking Upstream Activation and Reversing Activation State of Hepatic Stellate Cells., PMID:40228167
Development of Diphenyl-1,2,4-Oxadiazole Analogues as Allosteric Modulators of the RXFP3 Receptor: Evaluation of Importance of the N-Substituted-2-Pyrrolidone Moiety in RLX-33., PMID:40146900
Expression of relaxin-3 and its receptors in the hypothalamic-pituitary-ovary axis in layers and broiler breeders., PMID:40120249
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction., PMID:40037346
Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction., PMID:40001176
Relaxin-2 Exhibits a Beneficial Role in Energy Metabolism to Alleviate Atrial Fibrillation Susceptibility., PMID:39974648
Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases., PMID:39888342
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats., PMID:39815354
Pharmacokinetics Integrated With Network Pharmacology to Investigate the Potential Mechanism of Lu-Jiao Fang Inhibited Endothelial-to-Mesenchymal Transition in Pressure Overload-Induced Cardiac Fibrosis., PMID:39775935
Proteomic and cytokine profiling of a CTRP8-RXFP1 glioma mouse model., PMID:39709036
Spatial-temporal regulation of the prostanoid receptor EP2 co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium., PMID:39555416
Role of Relaxin Signaling in Cancer: A Review., PMID:39547477
C1QTNF Related protein 8 (CTRP8) is a marker of myeloid derived innate immune cell populations in the human breast cancer microenvironment., PMID:39542181
Multi-Omics Analysis Identified Drug Repurposing Targets for Chronic Obstructive Pulmonary Disease., PMID:39456887
Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium., PMID:39283953
Therapeutic potential of relaxin or relaxin mimetics in managing cardiovascular complications of diabetes., PMID:39182735
Engineering and Characterization of a Long-Half-Life Relaxin Receptor RXFP1 Agonist., PMID:39134056
Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure: A Phase 1a/b, First-in-Human, Randomized, Single-Blind, Placebo-Controlled Study., PMID:39056338
Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology., PMID:38945278
GPCR Function in Autophagy Control: A Systematic Approach of Chemical Intervention., PMID:38848865
Relaxin-2 is a novel biomarker for differentiated thyroid carcinoma in humans., PMID:38815632
Cardiomyocyte-specific RXFP1 overexpression protects against pressure overload-induced cardiac dysfunction independently of relaxin., PMID:38768763
The consequences of manipulating relaxin family peptide receptor 1 (RXFP1) level in ovarian cancer cells., PMID:38640630
Targeting the relaxin-3/RXFP3 system: a patent review for the last two decades., PMID:38573177
Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure., PMID:38502782
Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists., PMID:38502780
The involvement of the Wnt/β-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin., PMID:38490518
Doppler ultrasonographic scan, gene expression and serum profile of immune, APPs and antioxidant markers in Egyptian buffalo-cows with clinical endometritis., PMID:38459095
R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases., PMID:38450758
Maternal Fed Zinc-Deficient Diet: Effects on Relaxin Family Peptides and Oxidant System in the Testis and Liver Tissue of Male Offspring., PMID:38407794
Serelaxin Protects H9c2 Cardiac Myoblasts against Hypoxia and Reoxygenation-Induced Damage through Activation of AMP Kinase/Sirtuin1: Further Insight into the Molecular Mechanisms of the Cardioprotection of This Hormone., PMID:38397761
Targeting RXFP1 by Ligustilide: A novel therapeutic approach for alcoholic hepatic steatosis., PMID:38157696
Identification of biomarkers associated with pediatric asthma using machine learning algorithms: A review., PMID:38013370
Role of cAMP in Cardiomyocyte Viability: Beneficial or Detrimental?, PMID:37850368
Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives., PMID:37721595
Further Developments towards a Minimal Potent Derivative of Human Relaxin-2., PMID:37628851
Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights., PMID:37398174
Development of Novel High-Affinity Antagonists for the Relaxin Family Peptide Receptor 1., PMID:37200817
Serelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway., PMID:37176063
The relaxin receptor RXFP1 signals through a mechanism of autoinhibition., PMID:37081311
C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro., PMID:37047812
A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity., PMID:37047588
Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action., PMID:36982837
Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment., PMID:36921737
Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure., PMID:36780899
Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species., PMID:36764268
Porcine Relaxin but Not Serelaxin Shows Residual Bioactivity after In Vitro Simulated Intestinal Digestion-Clues for the Development of New Relaxin Peptide Agonists Suitable for Oral Delivery., PMID:36613489
Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis., PMID:36560925
For research use only. Not for human or drug use.
