Catalog No.
YHJ59201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Phe228
Predicted molecular weight
28.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HB71
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
S100A6-binding protein, SIP, Siah-interacting protein, CacyBP, CACYBP, hCacyBP, S100A6BP, Calcyclin-binding protein
CacyBP/SIP Protein Regulates the Length and Branching of Neuronal Processes During Cortical Development., PMID:40476326
Silencing CACYBP suppresses lung adenocarcinoma growth via CDK1 inhibition., PMID:40167359
Integrative machine learning frameworks to uncover specific protein signature in neuroendocrine cervical carcinoma., PMID:39794740
Evaluation of CacyBP/SIP expression and its relationship with ERK1/2 and p38 kinase in testicular seminoma., PMID:39644709
Identifying therapeutic targets for kidney stone disease through proteome-wide Mendelian randomization and colocalization analysis., PMID:39585470
Proteomics of severe SARS-COV-2 infection and paraquat poisoning in human lung tissue samples: comparison of microbial infected and toxic pulmonary fibrosis., PMID:39301288
Proteome-wide mendelian randomization identifies therapeutic targets for nephrolithiasis., PMID:39237840
Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys., PMID:39147716
Comparative assessment of CacyBP/SIP, β-catenin and cannabinoid receptors in the adrenals of hypertensive rats., PMID:38780511
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5., PMID:38558058
Chaperones-A New Class of Potential Therapeutic Targets in Alzheimer's Disease., PMID:38542375
Pan-analysis reveals CACYBP to be a novel prognostic and predictive marker for multiple cancers., PMID:38322570
Evaluation of the Expression and Localization of the Multifunctional Protein CacyBP/SIP and Elements of the MAPK Signaling Pathway in the Adrenal Glands of Rats with Primary and Secondary Hypertension., PMID:38203261
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma., PMID:37968706
Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis., PMID:37759433
Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma., PMID:37416927
The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma., PMID:37373509
Calcyclin-binding protein contributes to cholangiocarcinoma progression by inhibiting ubiquitination of MCM2., PMID:37305391
Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes., PMID:37156124
Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC., PMID:37077914
By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma., PMID:36776843
Molecular and immunological characterization of the calcyclin binding protein in rodent malaria parasite., PMID:36707015
CACYBP knockdown inhibits progression of prostate cancer via p53., PMID:36576589
Calcyclin-binding protein-promoted degradation of MdFRUCTOKINASE2 regulates sugar homeostasis in apple., PMID:36461944
Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension., PMID:36042446
MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET., PMID:35705526
Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication., PMID:35184390
Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct., PMID:35087201
Proteomic identification of arginine-methylated proteins in colon cancer cells and comparison of messenger RNA expression between colorectal cancer and adjacent normal tissues., PMID:35081685
Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling., PMID:34591648
[CacyBP promotes the proliferation and invasion of non-small cell lung cancer]., PMID:34530574
Downregulation of CacyBP by CRISPR/dCas9-KRAB Prevents Bladder Cancer Progression., PMID:34179100
A screening system for identifying interacting proteins using biomolecular fluorescence complementation and transposon gene trap., PMID:33989302
Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data., PMID:33868792
HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation., PMID:33049998
A Novel Signature Based on mTORC1 Pathway in Hepatocellular Carcinoma., PMID:33014055
CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells., PMID:32880469
CacyBP/SIP promotes tumor progression by regulating apoptosis and arresting the cell cycle in osteosarcoma., PMID:32742374
Establishment of a novel risk score model by comprehensively analyzing the immunogen database of bladder cancer to indicate clinical significance and predict prognosis., PMID:32570217
CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases., PMID:32544715
S100A6 and Its Brain Ligands in Neurodegenerative Disorders., PMID:32492924
Ageing-related changes in the levels of β-catenin, CacyBP/SIP, galectin-3 and immunoproteasome subunit LMP7 in the heart of men., PMID:32119722
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation., PMID:31754404
SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation., PMID:31213539
Bioinformatic analysis of Cacybp-associated proteins using human glioma databases., PMID:30762928
Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1., PMID:30656909
Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)., PMID:30577465
Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts., PMID:30482253
Comparative evaluation of CacyBP/SIP protein, β-catenin, and immunoproteasome subunit LMP7 in the heart of rats with hypertension of different etiology., PMID:30472885
Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling., PMID:30342273
For research use only. Not for human or drug use.
