Catalog No.
YHJ57901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr145-Thr357
Predicted molecular weight
26.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H7Z7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Microsomal prostaglandin E synthase 2, PGES2, Membrane-associated prostaglandin E synthase-2, Prostaglandin E synthase 2, Prostaglandin-H(2) E-isomerase, C9orf15, mPGES-2, mPGE synthase-2, PTGES2
Anti-inflammatory effect of photobiomodulation in the brain following local peripheral carrageenan-induced inflammation., PMID:40500489
Proteome-wide Ligand and Target Discovery by Using β-Nitrostyrene Electrophiles: Supporting Targeted Protein Degradation., PMID:40464197
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues., PMID:40385441
Effect of MiRNA 204-5P Mimics and Lipopolysaccharide-Induced Inflammation on Transcription Factor Levels, Cell Maintenance, and Retinoic Acid Signaling in Primary Limbal Epithelial Cells., PMID:40332443
Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition., PMID:40010271
LIN28B enhances the chemosensitivity of colon cancer cells via inducing genomic instability by upsetting the balance between the production and removal of reactive oxygen species., PMID:39986369
In vitro expression of genes encoding HIF1α, VEGFA, PGE2 synthases, and PGE2 receptors in feline oral squamous cell carcinoma., PMID:39930728
Discovery of novel microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitors by a structurally inspired virtual screening study., PMID:39893902
Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization., PMID:39885565
Activation of the COX-2/mPGES-1/PGE-2 cascade through the NLRP3 inflammasome contributes to Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis., PMID:39832004
2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitors., PMID:39817627
Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism., PMID:39788955
Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system., PMID:39754048
Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis., PMID:39738707
PTGES3 proteolysis using the liposomal peptide-PROTAC approach., PMID:39726032
5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates., PMID:39692230
Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever., PMID:39622054
Microsomal Prostaglandin E Synthase-1 Controls Colonic Prostaglandin E2 Production and Exerts a Protective Effect on Colitis Induced by Trinitrobenzene Sulfonic Acid in Mice., PMID:39596393
Neuronal PLPP/CIN exaggerates the immune response of hippocampal microglia to LPS challenge dependent on PAK1-NF-κB-COX-2 signaling pathway., PMID:39581524
Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development., PMID:39581452
Novel Synthesized Benzophenone Thiazole Hybrids Exhibited Ex Vivo and In Silico Anti-Inflammatory Activity., PMID:39424371
Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity., PMID:39298269
TNFα-Induced Inflammation Model-Evaluation of Concentration and Passage-Dependent Effects on Bovine Chondrocytes., PMID:39273085
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1., PMID:39255799
Modification of Regulatory Tyrosine Residues Biases Human Hsp90α in its Interactions with Cochaperones and Clients., PMID:39222679
Regular moderate physical activity potentially accelerates and strengthens both the pro-inflammatory and pro-resolving lipid mediator response after acute exercise stress., PMID:39216411
Progressively Diminished Prostaglandin E2 Signaling in Concordance with Increasing Fibrosis in Ectopic Endometrium., PMID:39174854
PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses., PMID:39035989
Activation of the PGE2-EP2 pathway as a potential drug target for treating eosinophilic rhinosinusitis., PMID:39015572
Attenuation of adjuvant-induced arthritis with carnosic acid by inhibiting mPGES-1, COX-2, and bone loss in male SD rats., PMID:39013842
Myeloid Cell mPGES-1 Deletion Attenuates Calcium Phosphate-induced Abdominal Aortic Aneurysm in Male Mice., PMID:38865056
Study on peripheral antinociception induced by hydrogen peroxide (H2O2): characterization and mechanisms., PMID:38753048
Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors., PMID:38653151
The components of the AhR-molecular chaperone complex differ depending on whether the ligands are toxic or non-toxic., PMID:38605276
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling., PMID:38583151
Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats., PMID:38545661
A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model., PMID:38521811
Expression of mPGES1 and p16 in feline and human oral squamous cell carcinoma: A comparative oncology approach., PMID:38378135
Effects of commonly used carbamates (carbaryl and thiram) on the regulatory, secretory and motor functions of bovine cervixes in vitro., PMID:38330862
A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's., PMID:38291895
Aspirin and Cancer Survival: An Analysis of Molecular Mechanisms., PMID:38201650
Progesterone-independent endometrial mRNA expression in dairy cows with clinical or subclinical endometritis., PMID:38183931
Mycobacterium marinum mediates regulation of prostaglandin E2 expression on host immune response through cyclooxygenase pathway., PMID:38183522
Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice., PMID:38164437
Inhibiting cholesterol de novo synthesis promotes hepatocellular carcinoma progression by upregulating prostaglandin E synthase 2-mediated arachidonic acid metabolism under high fatty acid conditions., PMID:38081591
Interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue., PMID:38032490
The effect of TLR3 priming conditions on MSC immunosuppressive properties., PMID:38031182
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential., PMID:38015194
Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53., PMID:37907523
Synthesis, structural and X-ray analysis evaluations and computational studies of newly tetrahydroisoquinoline derivatives as potent against microsomal prostaglandin E synthase 1., PMID:37878040
For research use only. Not for human or drug use.
