Catalog No.
YHJ57501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys689-Glu836
Predicted molecular weight
18.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H5V8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD318, Transmembrane and associated with src kinases, TRASK, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Membrane glycoprotein gp140, CUB domain-containing protein 1, CDCP1
Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines., PMID:40391211
CD6 in Human Disease., PMID:39996744
Receptor CDCP1 Is a Potential Target for Personalized Imaging and Treatment of Poor Outcome HER2+, Triple-Negative, and Metastatic ER+/HER2- Breast Cancers., PMID:39869307
Ligands of CD6: roles in the pathogenesis and treatment of cancer., PMID:39840036
Targeting CDCP1 boost CD8+ T cells-mediated cytotoxicity in cervical cancer via the JAK/STAT signaling pathway., PMID:39455095
Quantitative Membrane Proteomics for Discovery of Actionable Drug Targets at the Surface of RAS-Driven Human Cancer Cells., PMID:39052212
The CD318/CD6 axis limits type 1 diabetes islet autoantigen-specific human T cell activation., PMID:38642507
Evaluating the effects of circulating inflammatory proteins as drivers and therapeutic targets for severe COVID-19., PMID:38455043
Circulatory Inflammatory Proteins as Early Diagnostic Biomarkers for Invasive Aspergillosis in Patients with Hematologic Malignancies-an Exploratory Study., PMID:38407673
Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial., PMID:38296309
Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells., PMID:38280067
CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies., PMID:38139340
Circulating biomarkers in familial cerebral cavernous malformation., PMID:38113759
Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese., PMID:37918406
Activation of Cytotoxic Lymphocytes Through CD6 Enhances Killing of Cancer Cells., PMID:37886483
Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis., PMID:37800334
Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa., PMID:37672793
Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort., PMID:37584418
Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer., PMID:37468417
Glucose-dependent inflammatory responses in obese compared to lean individuals., PMID:37400734
Inflammatory Biomarkers in Newly Diagnosed Patients With Parkinson Disease and Related Neurodegenerative Disorders., PMID:37258413
Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis., PMID:37236058
Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF., PMID:37140510
Inhibition of CDCP1 by 8-isopentenylnaringenin synergizes with EGFR inhibitors in lung cancer treatment., PMID:37013960
Potential miRNA-gene interactions determining progression of various ATLL cancer subtypes after infection by HTLV-1 oncovirus., PMID:36978083
Detection and Isolation of Circulating Tumor Cells from Breast Cancer Patients Using CUB Domain-Containing Protein 1., PMID:36926972
Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein., PMID:36880252
An integrated co-expression network analysis reveals novel genetic biomarkers for immune cell infiltration in chronic kidney disease., PMID:36875100
CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma., PMID:36862682
Plasma proteins related to inflammatory diet predict future cognitive impairment., PMID:36737481
Proteomic profiling identifies novel independent relationships between inflammatory proteins and myocardial infarction., PMID:36702559
Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer., PMID:36648492
CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression., PMID:36593286
CD318 is a target of chimeric antigen receptor T cells for the treatment of colorectal cancer., PMID:36495368
Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection., PMID:36408648
Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress., PMID:36353616
Identification of immune-associated prognostic biomarkers in lung adenocarcinoma on the basis of gene co-expression network., PMID:36351297
The Effect of Heat Shock on Myogenic Differentiation of Human Skeletal-Muscle-Derived Mesenchymal Stem/Stromal Cells., PMID:36291076
CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy., PMID:36276654
Association of extracellular vesicle inflammatory proteins and mortality., PMID:35982068
CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis., PMID:35951427
Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition., PMID:35809567
AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer., PMID:35643725
CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease., PMID:35604681
Circulating virome and inflammatory proteome in patients with ST-elevation myocardial infarction and primary ventricular fibrillation., PMID:35552514
Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer., PMID:35513563
CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer., PMID:35504333
Antibodies Against Cleaved CDCP1 Show Activity in RAS-Mutant Tumors., PMID:35373280
Elevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease., PMID:35172279
Cleaved CDCP1 marks the spot: a neoepitope for RAS-driven cancers., PMID:35166242
For research use only. Not for human or drug use.
