Catalog No.
YHJ55301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys64-Ser285
Predicted molecular weight
28.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H254
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-IV spectrin, KIAA1642, SPTBN3, Spectrin, non-erythroid beta chain 3, SPTBN4, Spectrin beta chain, non-erythrocytic 4
Advancing Personalized Medicine in Alzheimer's Disease: Liquid Biopsy Epigenomics Unveil APOE ε4-Linked Methylation Signatures., PMID:40244264
βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia., PMID:39920295
Heterozygous loss-of-function variants in SPTAN1 cause a novel early childhood onset distal myopathy with chronic neurogenic features., PMID:39371122
Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction., PMID:38441922
Beta IV spectrin inhibits the metastatic growth of melanoma by suppressing VEGFR2-driven tumor angiogenesis., PMID:37680049
Endothelial tip/stalk cell selection requires BMP9-induced βIV-spectrin expression during sprouting angiogenesis., PMID:37126382
Spectrins: molecular organizers and targets of neurological disorders., PMID:36697767
Bioinformatic Analysis of Plus Gene Expression Related to Progression from Leukoplakia to Oral Squamous Cell Carcinoma., PMID:36444596
SPTBN5, Encoding the βV-Spectrin Protein, Leads to a Syndrome of Intellectual Disability, Developmental Delay, and Seizures., PMID:35782384
Loss of β4-spectrin impairs Nav channel clustering at the heminode and temporal fidelity of presynaptic spikes in developing auditory brain., PMID:35393465
Severe Form of ßIV-Spectrin Deficiency With Mitochondrial Dysfunction and Cardiomyopathy-A Case Report., PMID:33986717
Heterozygous variants in SPTBN1 cause intellectual disability and autism., PMID:33847457
Novel bi-allelic variants expand the SPTBN4-related genetic and phenotypic spectrum., PMID:33772159
Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome., PMID:33576403
Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women., PMID:32411801
A novel homozygous splice-site mutation in the SPTBN4 gene causes axonal neuropathy without intellectual disability., PMID:31857255
Detection of a Frameshift Deletion in the SPTBN4 Gene Leads to Prevention of Severe Myopathy and Postnatal Mortality in Pigs., PMID:31850074
The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance., PMID:31230720
βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy., PMID:29861105
Transcriptome analysis reveals enrichment of genes associated with auditory system in swimbladder of channel catfish., PMID:29738887
Expanding the genetic heterogeneity of intellectual disability., PMID:28940097
Postnatal Development of Spasticity Following Transgene Insertion in the Mouse βIV Spectrin Gene (SPTBN4)., PMID:28582869
A recessive mutation in beta-IV-spectrin (SPTBN4) associates with congenital myopathy, neuropathy, and central deafness., PMID:28540413
DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease., PMID:24030951
For research use only. Not for human or drug use.
