Catalog No.
YHJ52001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser29-Thr140
Predicted molecular weight
15.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BYZ8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Reg IV, Gastrointestinal secretory protein, REG-like protein, Regenerating islet-derived protein IV, REG-4, RELP, REG4, GISP, Regenerating islet-derived protein 4
Promising protein biomarkers for early gastric cancer: clinical performance of combined detection., PMID:40305430
Clinical efficacy and chemoresistance analysis of precision neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a prospective, single-arm pilot study., PMID:40146255
Intestinal Goblet Cell-Expressed Reg4 Ameliorates Intestinal Inflammation Potentially by Restraining Pathogenic Escherichia coli Infection., PMID:39724312
Gut microbiota CLA and IL-35 induction in macrophages through Gαq/11-mediated STAT1/4 pathway: an animal-based study., PMID:39636005
Elevated circulating regenerating islet-derived protein 4 levels in patients with metabolic syndrome and related to its key components., PMID:39412609
Effect of dark sweet cherry (Prunus avium) supplementation on the fecal microbiota, metabolic endotoxemia, and intestinal permeability in obese subjects: a single-blind randomized trial., PMID:39228354
Reduced Expression of REG4 as a Sign of Altered Goblet Cell Function in Necrotizing Enterocolitis., PMID:39008984
Tumour cell-derived serglycin promotes IL-8 secretion of CAFs in gastric cancer., PMID:38862740
Single-cell transcriptome reveals the heterogeneity of malignant ductal cells and the prognostic value of REG4 and SPINK1 in primary pancreatic ductal adenocarcinoma., PMID:38827297
Reg4 deficiency aggravates pancreatitis by increasing mitochondrial cell death and fibrosis., PMID:38769308
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders., PMID:38649851
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly., PMID:38569027
Antibacterial peptide Reg4 ameliorates Pseudomonas aeruginosa-induced pulmonary inflammation and fibrosis., PMID:38501823
Identification and immunoinfiltration analysis of key genes in ulcerative colitis using WGCNA., PMID:38426148
The association of tumor-expressed REG4, SPINK4 and alpha-1 antitrypsin with cancer-associated thrombosis in colorectal cancer., PMID:38066386
Dual function of angiogenin-4 inducing intestinal stem cells and apoptosis., PMID:38020881
Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly., PMID:37744296
Unraveling dynamic interactions between tumor-associated macrophages and consensus molecular subtypes in colorectal cancer: An integrative analysis of single-cell and bulk RNA transcriptome., PMID:37662758
The Efficacy of REG Proteins as a Diagnostic Biomarker for Pancreatic Cancer: a Meta-Analysis., PMID:37560856
The bioinformatics analysis of the clinicopathological and prognostic significances of REG4 mRNA in gynecological cancers., PMID:37218920
Intestinal Reg4 deficiency confers susceptibility to high-fat diet-induced liver steatosis by increasing intestinal fat absorption in mice., PMID:37138677
Single-cell profiling reveals differences between human classical adenocarcinoma and mucinous adenocarcinoma., PMID:36690709
Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13., PMID:36414210
Reg4 protects against Salmonella infection-associated intestinal inflammation via adopting a calcium-dependent lectin-like domain., PMID:36274484
REG4 promotes the proliferation and anti-apoptosis of cancer., PMID:36172286
All-trans retinoic acid enhances the anti-tumour effects of fimaporfin-based photodynamic therapy., PMID:36108391
Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24., PMID:35946046
The effects of REG4 expression on chemoresistance of ovarian cancer., PMID:35929918
Deeper insights into long-term survival heterogeneity of pancreatic ductal adenocarcinoma (PDAC) patients using integrative individual- and group-level transcriptome network analyses., PMID:35773268
Unravelling of the comparative Transcriptomic Profile of Gallbladder Cancer using mRNA sequencing., PMID:35469389
Gut microbiota-derived metabolite 3-idoleacetic acid together with LPS induces IL-35+ B cell generation., PMID:35074011
Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells., PMID:34910127
Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells., PMID:34753802
Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer., PMID:34577861
Screening and discrimination of optimal prognostic genes for pancreatic cancer based on a prognostic prediction model., PMID:34499727
The Potential Role of REG Family Proteins in Inflammatory and Inflammation-Associated Diseases of the Gastrointestinal Tract., PMID:34281249
Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling., PMID:33899235
Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer., PMID:33659040
CDX2 and Reg IV expression and correlation in gastric cancer., PMID:33639844
Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut., PMID:32879431
Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer., PMID:31905926
[Identification of gene biomarkers to predict responses to neoadjuvant chemoradiotherapy in patients with rectal cancer and pathways enrichment analysis]., PMID:31874536
Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma., PMID:31659102
A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling., PMID:31605540
REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression., PMID:31428934
Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition., PMID:30953001
Single-chain Antibody Against Reg4 Suppresses Gastric Cancer Cell Growth and Enhances 5-FU-induced Cell Death in vitro., PMID:30465515
BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice., PMID:30448068
Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction., PMID:29850784
Expression of Reg IV and SOX9 and their correlation in human gastric cancer., PMID:29587675
For research use only. Not for human or drug use.
