Catalog No.
YHJ51301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val377
Predicted molecular weight
44.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BY41
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HDAC8, Histone deacetylase 8, HD8, HDACL1
Novel Heterocyclic Compounds Exhibit Potent Antileukemic Activity through Selective Induction of Apoptosis and HDAC8 Interaction in AML Cells., PMID:40491377
Synergistic HDAC4/8 Inhibition Sensitizes Osteosarcoma to Doxorubicin via pAKT/RUNX2 Pathway Modulation., PMID:40332124
Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance., PMID:40254688
The combined effects of HSV-1 glycoprotein D and aluminum hydroxide on human neuroblastoma cells: Insights into oxidative DNA damage, apoptosis, and epigenetic modifications., PMID:40112954
Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis., PMID:40085643
Genetically Encoded Fluorescent and Bioluminescent Probes for HDAC8., PMID:40045791
CK2B Induces CD8+ T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer., PMID:40013761
Fluorogenic selective detection of Zn2+ using a pyrazole-ortho-vanillin conjugate: insights from DFT, molecular docking, bioimaging and anticancer applications., PMID:39950208
Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051., PMID:39939814
lncRNA ENST000000454471 promotes lung adenocarcinoma progression and tumor immune escape: Protein structure and biological functions of histone deacetylase 8., PMID:39909272
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis., PMID:39896484
Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8., PMID:39779705
Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells., PMID:39707321
A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line., PMID:39704853
Genome Instability and Senescence Are Markers of Cornelia de Lange Syndrome Cells., PMID:39682772
Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions., PMID:39611171
Histone deacetylase 8 in focus: Decoding structural prerequisites for innovative epigenetic intervention beyond hydroxamates., PMID:39608552
Repurposing of DrugBank molecules as dual non-hydroxamate HDAC8 and HDAC2 inhibitors by pharmacophore modeling, molecular docking, and molecular dynamics studies., PMID:39604351
YAK577 Attenuates Cardiac Remodeling and Fibrosis in Isoproterenol-Infused Heart Failure Mice by Downregulating MMP12., PMID:39601396
Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off-target effects., PMID:39482806
Butyrate Inhibits the HDAC8/NF-κB Pathway to Enhance Slc26a3 Expression and Improve the Intestinal Epithelial Barrier to Relieve Colitis., PMID:39440960
Knockout of histone deacetylase 8 gene in breast cancer cells may alter the expression pattern of the signaling molecules., PMID:39437892
dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation., PMID:39437453
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models., PMID:39436709
HDAC8 as a target in drug discovery: Function, structure and design., PMID:39427514
Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders., PMID:39423771
Discovery of organosulfur-based selective HDAC8 inhibitors with anti-neuroblastoma activity., PMID:39357770
Inhibition of HDAC8 mitigates AKI by reducing DNA damage and promoting homologous recombination repair., PMID:39317961
ZNF521 promotes acute myeloid leukemogenesis by suppressing the expression and acetylation of SMC3., PMID:39309877
Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial-mesenchymal transition and invasion., PMID:39286495
N-Myc and STAT Interactor is an Endometriosis Suppressor., PMID:39125716
N-(2-Hydroxyphenyl)-2-Propylpentanamide (HO-AAVPA) Induces Apoptosis and Cell Cycle Arrest in Breast Cancer Cells, Decreasing GPER Expression., PMID:39124913
A patent review of histone deacetylase 8 (HDAC8) inhibitors (2013-present)., PMID:39121339
Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer., PMID:39110628
Anti-tumour activity of Panobinostat in oesophageal adenocarcinoma and squamous cell carcinoma cell lines., PMID:39097736
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors., PMID:39089850
HDAC8 Enhances the Function of HIF-2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC., PMID:39073752
Reversible acetylation of HDAC8 regulates cell cycle., PMID:39043961
Crucial Structural Understanding for Selective HDAC8 Inhibition: Common Pharmacophores, Molecular Docking, Molecular Dynamics, and Zinc Binder Analysis of selective HDAC8 inhibitors., PMID:39039678
Histone deacetylase 8 promotes innate antiviral immunity through deacetylation of RIG-I., PMID:39035358
Chitosan-enclosed SLN improved SV-induced hepatocellular cell carcinoma death by modulation of IQGAP gene expression, JNK, and HDAC activities., PMID:39023688
Design and evaluation of nanoscale materials with programmed responsivity towards epigenetic enzymes., PMID:39021201
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the "Smart" exosome nanoparticle therapy., PMID:39004737
Synthesis and cytotoxic evaluation of heterocyclic compounds by vinylic substitution of ketene dithioacetals., PMID:38997237
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8., PMID:38949959
Rapid Determination of Kinetic Constants for Slow-Binding Inhibitors and Inactivators of Human Histone Deacetylase 8., PMID:38891780
Discovery of a dual-target DYRK2 and HDAC8 inhibitor for the treatment of hepatocellular carcinoma., PMID:38889633
Unveiling critical structural features for effective HDAC8 inhibition: a comprehensive study using quantitative read-across structure-activity relationship (q-RASAR) and pharmacophore modeling., PMID:38871969
The Importance of Structural Water in HDAC8 for Correct Binding Pose Applied for Drug Design of Anticancer Molecules., PMID:38835122
Replacement of the hydroxamic acid group in the selective HDAC8 inhibitor PCI-34051., PMID:38782078
For research use only. Not for human or drug use.
