Catalog No.
YHJ51101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly27-His272
Predicted molecular weight
30.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BXY4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RSPO3, hPWTSR, hRspo3, PWTSR, R-spondin-3, Thrombospondin type-1 domain-containing protein 2, Protein with TSP type-1 repeat, Roof plate-specific spondin-3, THSD2
Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization., PMID:40450304
Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration., PMID:40440122
Phylogenetic Insights into the Evolutionary History of the RSPO Gene Family in Metazoa., PMID:40428299
Protein interaction network drive more group integrated analytic larynx hub protein markers: LYVE1/FBLN5/INMT/DCN/ZFY/RSPO3 protein macromolecule collaborative diagnosis of a new era., PMID:40419046
Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca2+/Calcineurin/NFAT1-dependent anti-EndMT pathway., PMID:40398181
Comprehensive circRNA expression profile and hub genes screening during human liver development., PMID:40285372
Associations of 2923 plasma proteins with incident inflammatory bowel disease in a prospective cohort study and genetic analysis., PMID:40118817
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3., PMID:40074890
Identification of potential druggable targets for endometriosis through Mendelian randomization analysis., PMID:39911230
Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice., PMID:39854351
RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway., PMID:39760688
Coactivation of Tie2 and Wnt signaling using an antibody-R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia., PMID:39607038
Decreased RSPO3 and β-Catenin in Preeclampsia: Correlation with Blood Pressure and Pregnancy Outcomes., PMID:39568191
LGR6 protects against myocardial ischemia-reperfusion injury via suppressing necroptosis., PMID:39471639
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health., PMID:39453386
The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells., PMID:39351282
RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis., PMID:39245068
An "R-spondin code" for multimodal signaling ON-OFF states., PMID:39180250
Proteomics profiling and association with cardiorenal complications in type 2 diabetes subtypes in Asian population., PMID:39059739
Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis., PMID:39038735
Identifying novel potential drug targets for endometriosis via plasma proteome screening., PMID:39036049
Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury., PMID:38677673
Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence., PMID:38591545
RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β-catenin signaling pathway., PMID:38581123
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization., PMID:38515381
Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps., PMID:38473810
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice., PMID:38440827
LGR5 Expression Predicting Poor Prognosis Is Negatively Correlated with WNT5A in Colon Cancer., PMID:37998393
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma., PMID:37932819
Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration., PMID:37898454
Identification of Clinically Relevant Brain Endothelial Cell Biomarkers in Plasma., PMID:37814955
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos., PMID:37767857
Identification of the shared gene signatures between pulmonary fibrosis and pulmonary hypertension using bioinformatics analysis., PMID:37731513
Increased R-spondin 3 contributes to aerobic exercise-induced protection against renal vascular endothelial hyperpermeability and acute kidney injury., PMID:37607126
Effect of Exogenous Hormone on R-Spondin 2 (Rspo2) and R-Spondin 3 (Rspo3) Gene Expression and Embryo Development in Chinese Soft-Shelled Turtle (Pelodiscus sinensis)., PMID:37510371
Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration., PMID:37481204
Genetic insight into the putative causal proteins and druggable targets of osteoporosis: a large-scale proteome-wide mendelian randomization study., PMID:37448626
An integrated single-cell analysis of human adrenal cortex development., PMID:37440461
Identification of potential drug targets for varicose veins: a Mendelian randomization analysis., PMID:37404740
Identification of New Key Genes and Their Association with Breast Cancer Occurrence and Poor Survival Using In Silico and In Vitro Methods., PMID:37238942
Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKα axis., PMID:37173190
R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice., PMID:37165865
Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis., PMID:37051672
The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models., PMID:36922934
Integrated analysis of RNA-seq in hepatocellular carcinoma reveals competing endogenous RNA network composed of circRNA, lncRNA, and mRNA., PMID:36827016
RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells., PMID:36813038
Nanoplastics exposure induces vascular malformation by interfering with the VEGFA/VEGFR pathway in zebrafish (Danio rerio)., PMID:36427586
R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton., PMID:36321691
Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple cancer types., PMID:36255654
Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice., PMID:36222588
For research use only. Not for human or drug use.
