Catalog No.
YHJ50901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser234-Cys1396
Predicted molecular weight
131.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BXP8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PLAC3, PAPP-E, PAPPA2, PAPP-A2, Pregnancy-associated plasma protein A2, Pregnancy-associated plasma protein E1, Pappalysin-2
The Proteinase PAPP-A has Deep Evolutionary Roots Outside of the IGF System., PMID:40084812
Transcript Changes of Placental Tissue in Gestational Diabetes Mellitus Based on Transcriptome Sequencing., PMID:39882105
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:39809772
Exploring gene expression signatures in preeclampsia and identifying hub genes through bioinformatic analysis., PMID:39675129
ALKBH5 Reduces BMP15 mRNA Stability and Regulates Bovine Puberty Initiation Through an m6A-Dependent Pathway., PMID:39519156
Genetic analysis of the PAPP-A2 gene and evaluation of free IGF-1, IGFBP-5, and ALS concentrations in a group of 22 patients with idiopathic short stature., PMID:39279312
Analysis of Predictive Information From Biomarkers Added to Clinical Models of Preeclampsia: Consideration of PAPP-A2, Activin A, and sFlt-1:PlGF Ratio., PMID:38787345
Implication of Pappalysins and Stanniocalcins in the Bioavailability of IGF-I in Children With Type 1 Diabetes Mellitus., PMID:38712328
Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels., PMID:38662803
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:38633783
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments., PMID:38589872
The IGF-PAPP-A-Stanniocalcin Axis in Serum and Ascites Associates with Prognosis in Patients with Ovarian Cancer., PMID:38396692
Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population., PMID:38245583
Increased IGFBP Proteolysis, IGF-I Bioavailability, and Pappalysin Levels in Children With Prader-Willi Syndrome., PMID:38141219
Clinical Application of a Graphene Oxide-Based Surface Plasmon Resonance Biosensor to Measure First-Trimester Serum Pregnancy-Associated Plasma Protein-A/A2 Ratio to Predict Preeclampsia., PMID:38090367
Reduction in Pappalysin-2 Levels and Lower IGF-I Bioavailability in Female Adolescents With Anorexia Nervosa., PMID:38066647
Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition., PMID:37898658
Genome-wide association study identifying variants related to performance and injury in high-performance athletes., PMID:37750015
Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System., PMID:37231893
Impact of mini-driver genes in the prognosis and tumor features of colorectal cancer samples: a novel perspective to support current biomarkers., PMID:37214090
Integration of Selection Signatures and Protein Interactions Reveals NR6A1, PAPPA2, and PIK3C2B as the Promising Candidate Genes Underlying the Characteristics of Licha Black Pig., PMID:37106701
The Stanniocalcin-PAPP-A-IGFBP-IGF Axis., PMID:36718521
Five-Year Therapy with Recombinant Human Insulin-Like Growth Factor-1 in a Patient with PAPP-A2 Deficiency., PMID:36646053
Developmental dysplasia of the hip: A systematic review of susceptibility genes and epigenetics., PMID:36435507
Defining the origin, evolution, and immune composition of SDH-deficient renal cell carcinoma., PMID:36345344
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition., PMID:36127359
Pappalysins and Stanniocalcins and Their Relationship With the Peripheral IGF Axis in Newborns and During Development., PMID:35902207
Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta., PMID:35867736
PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non-small cell lung cancer., PMID:35811392
Placenta-specific lncRNA 1600012P17Rik is expressed in spongiotrophoblast and glycogen trophoblast cells of mouse placenta., PMID:35486179
GH Resistance Is a Component of Idiopathic Short Stature: Implications for rhGH Therapy., PMID:34956092
Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease., PMID:34944082
circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion., PMID:34934095
PAPPA2 Promote the Proliferation of Dermal Papilla Cells in Hu Sheep (Ovis aries) by Regulating IGFBP5., PMID:34680885
Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height, and PAPPA2 Genotype., PMID:34476481
Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse., PMID:34469481
Adult height and long-term outcomes after rhIGF-1 therapy in two patients with PAPP-A2 deficiency., PMID:34358737
Short stature with low insulin-like growth factor 1 availability due to pregnancy-associated plasma protein A2 deficiency in a Saudi family., PMID:34272725
Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip., PMID:34203285
Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation., PMID:34154587
Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women., PMID:34116346
Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency., PMID:33919940
Immunoassay-Amplified Responses Using a Functionalized MoS2-Based SPR Biosensor to Detect PAPP-A2 in Maternal Serum Samples to Screen for Fetal Down's Syndrome., PMID:33859474
Celastrol Prevents Oxidative Stress Effects on FSHR, PAPP, and CYP19A1 Gene Expression in Cultured Human Granulosa-Lutein Cells., PMID:33808393
Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults., PMID:33783375
Predictive values of various serum biomarkers in women with suspected preeclampsia: A prospective study., PMID:33616216
Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling., PMID:33508770
Preconceptional Lipid-Based Nutrient Supplementation in 2 Low-Resource Countries Results in Distinctly Different IGF-1/mTOR Placental Responses., PMID:33382407
Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25.2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci., PMID:33226468
Does height and IGF-I determine pubertal timing in girls?, PMID:33142306
For research use only. Not for human or drug use.
