Catalog No.
YHJ50101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr68-Trp247
Predicted molecular weight
22.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BVC4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GBL, TORC subunit LST8, Mammalian lethal with SEC13 protein 8, G protein beta subunit-like, Gable, Protein GbetaL, mLST8, LST8, MLST8, Target of rapamycin complex subunit LST8
MLST8 overexpression in RPE cells disrupts autophagy through novel mechanisms affecting AMD pathogenesis., PMID:40205682
Transcriptome analysis of 3D4/21 cells expressing CSFV NS4B., PMID:39967738
Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice., PMID:39957408
Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain., PMID:39337528
Mesangial cell-derived CircRNAs in chronic glomerulonephritis: RNA sequencing and bioinformatics analysis., PMID:38946402
Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer., PMID:38800011
SUMO modifies GβL and mediates mTOR signaling., PMID:38395307
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1., PMID:38284316
THADA inhibits autophagy and increases 5-FU sensitivity in gastric cancer cells via the PI3K/AKT/mTOR signaling pathway., PMID:38234670
circELP2 reverse-splicing biogenesis and function as a pro-fibrogenic factor by targeting mitochondrial quality control pathway., PMID:38159063
Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation., PMID:37688978
mLST8 is essential for coronavirus replication and regulates its replication through the mTORC1 pathway., PMID:37377422
Effects of Aspergillus-meal prebiotic diet on the growth performance, health status and gut microbiota of Asian seabass, Lates calcarifer., PMID:36935042
UBXN2A, a Ubiquitin-Like Protein, Alters Proteins in mTORC2 Pathway., PMID:36889268
A simple, rapid, and efficient method for generating multigene-knockout culture cells by the CRISPR/Cas9 system., PMID:36861495
Investigation of cytotoxic and apoptotic effects of disodium pentaborate decahydrate on ovarian cancer cells and assessment of gene profiling., PMID:36308567
Genetic predisposition to porto-sinusoidal vascular disorder: A functional genomic-based, multigenerational family study., PMID:35989577
Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling., PMID:35776786
The role of the PTEN/mTOR axis in clinical response of rectal cancer patients., PMID:35729481
Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNA., PMID:35579750
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway., PMID:35239512
Meta-analysis of the association between mTORC1-related genes polymorphisms and cancer risk., PMID:34839094
CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma., PMID:34741373
Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure., PMID:34698247
Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1., PMID:34529665
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy., PMID:34382907
R (-)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine., PMID:34023336
How autophagy controls the intestinal epithelial barrier., PMID:33906557
Genomic Database Analysis for Head and Neck Cancer Prevention Targets: MTOR Signal Transduction Pathway., PMID:32988862
RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1., PMID:32801163
l-Arginine supplementation of gilts during early gestation modulates energy sensitive pathways in pig conceptuses., PMID:32592179
STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells., PMID:32495998
miR-34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ-8073/CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways., PMID:32474960
ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma., PMID:32166592
Enhanced mLST8 Expression Correlates with Tumor Progression in Hepatocellular Carcinoma., PMID:32157528
MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway., PMID:31915116
Expression and activity of AIM2-inflammasome in rheumatoid arthritis patients., PMID:31836304
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia., PMID:31780813
Dietary non-protein energy source regulates antioxidant status and immune response of barramundi (Lates calcarifer)., PMID:31712130
Effects of single-nucleotide polymorphisms in the mTORC1 pathway on the risk of brain metastasis in patients with non-small cell lung cancer., PMID:31641854
Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+ 4/CD44+ prostate cancer stem cells., PMID:31630355
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly., PMID:31253771
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome., PMID:31120189
Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo., PMID:31085701
Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis., PMID:31076559
Regulation of the expression of key signalling molecules in mTOR pathway of skeletal muscle satellite cells in neonatal chicks: Effects of leucine and glycine-leucine peptide., PMID:30900779
Taurine Promotes Milk Synthesis via the GPR87-PI3K-SETD1A Signaling in BMECs., PMID:30678459
Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes., PMID:30650200
Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates., PMID:30647914
Identification and targeting of novel CDK9 complexes in acute myeloid leukemia., PMID:30587525
For research use only. Not for human or drug use.
