Catalog No.
YHJ50001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln193-Asp444
Predicted molecular weight
30.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BUZ4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CART1, MLN62, RING finger protein 83, TRAF4, MLN 62, Cysteine-rich domain associated with RING and Traf domains protein 1, RNF83, Metastatic lymph node gene 62 protein, TNF receptor-associated factor 4
OTUB1 promotes glioma progression by stabilizing TRAF4., PMID:40090557
Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4., PMID:39721246
Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine., PMID:39716976
MAP3K4 signaling regulates HDAC6 and TRAF4 coexpression and stabilization in trophoblast stem cells., PMID:39710325
CircWDR37 promotes hepatocellular carcinoma tumorigenesis by mediating the miR-646/TRAF4 regulatory pathway., PMID:39427585
[TRAF4 promotes lung cancer development by activating tyrosine kinase of EGFR]., PMID:39414598
Functional analyses of TRAF6 gene in Argopecten scallops., PMID:38354964
TRAF4-Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation-Induced Colorectal Cancer Progression., PMID:38229144
TRAF4 regulates ubiquitination-modulated survivin turnover and confers radioresistance., PMID:38164179
TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation., PMID:37607012
TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer., PMID:37155905
IL-33 promotes double negative T cell survival via the NF-κB pathway., PMID:37019882
USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis., PMID:37006049
TRAF4 Silencing Induces Cell Apoptosis and Improves Retinoic Acid Sensitivity in Human Neuroblastoma., PMID:36795185
TRAF4-mediated ubiquitination-dependent activation of JNK/Bcl-xL drives radioresistance., PMID:36765039
SRC-3/TRAF4 facilitates ovarian cancer development by activating the PI3K/AKT signaling pathway., PMID:36625999
De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation., PMID:36622335
Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance., PMID:36535926
Structure of fish TRAF4 and its implication in TRAF4-mediated immune cell and platelet signaling., PMID:36455779
Grouper TRIM23 exerts antiviral activity against iridovirus and nodavirus., PMID:36203610
TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway., PMID:36077559
TRAF4 promotes the malignant progression of high-grade serous ovarian cancer by activating YAP pathway., PMID:36029535
TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance., PMID:35895752
TRAF4 hyperactivates HER2 signaling and contributes to Trastuzumab resistance in HER2-positive breast cancer., PMID:35864174
Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5., PMID:35748027
TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling., PMID:35731212
The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis., PMID:35625561
The role of microRNA-4723-5p regulated by c-myc in triple-negative breast cancer., PMID:35382692
LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b., PMID:34983361
The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1., PMID:33991522
Inflammation accelerates copper-mediated cytotoxicity through induction of six-transmembrane epithelial antigens of prostate 4 expression., PMID:33179273
miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors., PMID:33171493
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy., PMID:33152664
TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin., PMID:32671611
TRAF4 knockdown triggers synergistic lethality with simultaneous PARP1 inhibition in endometrial cancer., PMID:32388810
MicroRNA-4443 regulates monocyte activation by targeting tumor necrosis factor receptor associated factor 4 in stroke-induced immunosuppression., PMID:32337817
High expression of TRAF4 predicts poor prognosis in tamoxifen-treated breast cancer and promotes tamoxifen resistance., PMID:32304412
TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2., PMID:32268273
Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness., PMID:32188842
MIR210HG promotes cell proliferation and invasion by regulating miR-503-5p/TRAF4 axis in cervical cancer., PMID:32087604
ZFPM2-AS1 facilitates cell growth in esophageal squamous cell carcinoma via up-regulating TRAF4., PMID:32065218
Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells., PMID:31553645
Placental production of progestins is fully effective in villous cytotrophoblasts and increases with the syncytiotrophoblast formation., PMID:31539598
Long non‑coding RNA DLEU1 promotes cell proliferation of glioblastoma multiforme., PMID:31257517
TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2., PMID:31076633
TRAF4 Promotes Fibroblast Proliferation in Keloids by Destabilizing p53 via Interacting with the Deubiquitinase USP10., PMID:30940456
Expression and Association of Tumor Necrosis Factor Receptor Associated Factor 4 (TRAF4) in Esophageal Squamous Cell Carcinoma., PMID:30933965
Re: TRAF4-Mediated Ubiquitination of NGF Receptor TrkA Regulates Prostate Cancer Metastasis., PMID:30634343
TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation., PMID:30352854
miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis., PMID:30348972
For research use only. Not for human or drug use.
