Catalog No.
YHJ49901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser119-Val331
Predicted molecular weight
50.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BUD6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DIL-1, SPON2, Mindin, DIL1, Differentially expressed in cancerous and non-cancerous lung cells 1, Spondin-2
Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer., PMID:40316856
Spatial immune scoring system predicts hepatocellular carcinoma recurrence., PMID:40074893
PSMD14 Transcriptionally Activated by MEF2A Promotes Pancreatic Cancer Development by Upregulating SPON2 Expression., PMID:40066751
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
Spatial Genomics Identifies Heat Shock Proteins as Key Molecular Changes Associated to Adipose Periprostatic Space Invasion in Prostate Cancer., PMID:39796635
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene., PMID:39731162
Epigenetic mechanisms of osteoarthritis risk in human skeletal development., PMID:38766055
The biological functions and related signaling pathways of SPON2., PMID:38264743
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study., PMID:37807083
Comprehensive analysis of the oncogenic and immunological role of SPON2 in human tumors., PMID:37713832
Tumor Targeting with Apatinib-loaded Nanoparticles and Sonodynamic Combined Therapy., PMID:37312441
Knockdown of SPON2 inhibits the growth of triple-negative breast cancer., PMID:36959811
Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis., PMID:36528128
SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway., PMID:36427776
Tumor-derived exosomal HOTAIRM1 regulates SPON2 in CAFs to promote progression of lung adenocarcinoma., PMID:36153414
Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin., PMID:36130502
Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment., PMID:36012576
Sjögren's and non-Sjögren's sicca share a similar symptom burden but with a distinct symptom-associated proteomic signature., PMID:35589331
The Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing., PMID:35250290
Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC., PMID:34583750
Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning., PMID:34445986
Cancer-associated Fibroblast-derived Spondin-2 Promotes Motility of Gastric Cancer Cells., PMID:34183385
The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma., PMID:33998076
Single-cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium., PMID:33710643
Corrigendum: Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis., PMID:33644080
Expression of Extracellular Matrix-Related Genes and Their Regulatory microRNAs in Problematic Colorectal Polyps., PMID:33322258
The Comparison Spondin 2 Levels in Primary Glomerular Diseases., PMID:33229764
Identification of Prognosis-Related Genes in Bladder Cancer Microenvironment across TCGA Database., PMID:33204728
Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis., PMID:32974343
Overexpression of Spondin-2 Is Associated with Recurrence-Free Survival in Patients with Localized Clear Cell Renal Cell Carcinoma., PMID:32952742
PIK3AP1 and SPON2 Genes Are Differentially Methylated in Patients With Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis (PFAPA) Syndrome., PMID:32793186
Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice., PMID:32614521
MINDIN secretion by prostate tumors induces premetastatic changes in bone via β-catenin., PMID:32357310
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development., PMID:32157178
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells., PMID:31691494
Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females., PMID:31599692
Prostate Cancer Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer Using a Unique Biparametric MRI and Expression of 11 Genes in Apparently Benign Tissue: Evaluation Using Machine-Learning Techniques., PMID:31588660
Differential expression of extracellular matrix‑related genes DCN, EPHA4, FN1, SPARC, SPON2 and SPP1 in colorectal carcinogenesis., PMID:31524274
The secreted matrix protein mindin increases prostate tumor progression and tumor-bone crosstalk via ERK 1/2 regulation., PMID:31168562
FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma., PMID:30736838
Study of Human T21 Placenta Suggests a Potential Role of Mesenchymal Spondin-2 in Placental Vascular Development., PMID:30715257
Spondin-2 is a novel diagnostic biomarker for laryngeal squamous cell carcinoma., PMID:30527359
Upregulation of Spondin-2 protein expression correlates with poor prognosis in hepatocellular carcinoma., PMID:30318967
Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients., PMID:30276603
A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of the Proteins Secreted by Human Adipose-Derived Mesenchymal Stem Cells., PMID:30226075
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma., PMID:30175151
A hnRNP K⁻AR-Related Signature Reflects Progression toward Castration-Resistant Prostate Cancer., PMID:29966326
FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications., PMID:29934339
SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways., PMID:29440144
Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering., PMID:29335477
For research use only. Not for human or drug use.
