Catalog No.
YHJ49401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu222
Predicted molecular weight
28.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BS40
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Latexin, Tissue carboxypeptidase inhibitor, LXN, Endogenous carboxypeptidase inhibitor, TCI, ECI, Protein MUM
Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics., PMID:39827250
Latexin (LXN) enhances tumor immune surveillance in mice by inhibiting Treg cells through the macrophage exosome pathway., PMID:39694381
Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation., PMID:39424784
HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma., PMID:39343971
Carboxypeptidase inhibitor Latexin (LXN) regulates intestinal organogenesis and intestinal remodeling involved in intestinal injury repair in mice., PMID:39208900
Genetics of Cardiac Aging Implicate Organ-Specific Variation., PMID:39148824
Preoperative camrelizumab combined with chemotherapy for borderline resectable ESCC: A single-arm, prospective, phase 2 study., PMID:39121854
Therapeutic potential of ADSC-EV-derived lncRNA DLEU2: A novel molecular pathway in alleviating sepsis-induced lung injury via the miR-106a-5p/LXN axis., PMID:38442573
Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin., PMID:37041202
Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight/obesity and metabolic syndrome., PMID:36964401
Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p., PMID:36949500
Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1., PMID:36933218
Diosgenin inhibits prostate cancer progression by inducing UHRF1 protein degradation., PMID:36681316
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation., PMID:36271146
Oxidative Stress Can Be Attenuated by 4-PBA Caused by High-Fat or Ammonia Nitrogen in Cultured Spotted Seabass: The Mechanism Is Related to Endoplasmic Reticulum Stress., PMID:35883767
Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells., PMID:35277124
Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus., PMID:35271662
Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet., PMID:35210404
N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets., PMID:34136404
LXN deficiency regulates cytoskeleton remodelling by promoting proteolytic cleavage of Filamin A in vascular endothelial cells., PMID:34085389
Proteomic identification of biomarkers in maternal plasma that predict the outcome of rescue cerclage for cervical insufficiency., PMID:33857242
Overexpression of hsa_circ_0094742 inhibits IL-1β-induced decline in CHON-001 cell viability by targeting microRNA-127-5p., PMID:33665792
Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway., PMID:32555320
RNA Sequencing revealed differentially expressed genes functionally associated with immunity and tumor suppression during latent phase infection of a vv + MDV in chickens., PMID:31578366
Latexin expression correlated with mineralization of articular cartilage during progression of post-traumatic osteoarthritis in a rat model., PMID:31313823
The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy., PMID:30914656
Elevated expression of Twinfilin-1 is correlated with inferior prognosis of lung adenocarcinoma., PMID:30391462
Latexin and hematopoiesis., PMID:29608488
Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro., PMID:28817687
In Silico Prediction and Validation of Gfap as an miR-3099 Target in Mouse Brain., PMID:28597341
Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice., PMID:28330618
Lactucaxanthin - a potential anti-diabetic carotenoid from lettuce (Lactuca sativa) inhibits α-amylase and α-glucosidase activity in vitro and in diabetic rats., PMID:28170007
Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance., PMID:28087740
Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma., PMID:26530530
Claustrum: a case for directional, excitatory, intrinsic connectivity in the rat., PMID:26329935
LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation., PMID:26317789
PRR11 Is a Prognostic Marker and Potential Oncogene in Patients with Gastric Cancer., PMID:26252227
Thymosin α1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1., PMID:26111447
Effects of AGBL2 on cell proliferation and chemotherapy resistance of gastric cancer., PMID:25916089
Latexin inhibits the proliferation of CD133+ miapaca-2 pancreatic cancer stem-like cells., PMID:25551472
Proteomic analysis of rat cartilage: the identification of differentially expressed proteins in the early stages of osteoarthritis., PMID:25435813
Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway., PMID:25341047
Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer., PMID:24884516
Latexin exhibits tumor suppressor potential in hepatocellular carcinoma., PMID:24399246
The expression of stem cell protein Piwil2 and piR-932 in breast cancer., PMID:23992744
Clinical significance of CD146 and latexin during different stages of thyroid cancer., PMID:23712706
Retinoic acid represses invasion and stem cell phenotype by induction of the metastasis suppressors RARRES1 and LXN., PMID:23588494
The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma., PMID:23364479
Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth., PMID:23028717
The SNP rs6441224 influences transcriptional activity and prognostically relevant hypermethylation of RARRES1 in prostate cancer., PMID:22573467
For research use only. Not for human or drug use.
