Catalog No.
YHJ49301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu171-Gly406
Predicted molecular weight
26.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BRQ0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pygopus homolog 2, PYGO2
PYGO2 regulates IL10 and plays immunosuppressive role through ESCC progression., PMID:40301712
Histopathological Evaluation of PYGO2 Expression in Esophageal Squamous Cell Carcinoma., PMID:40034933
PYGO2 promotes resistance to chemotherapy via reducing apoptosis and G2/M cell cycle arrest in esophageal carcinoma cells., PMID:39808374
EFNA4 deletion suppresses the migration, invasion, stemness, and angiogenesis of gastric cancer cells through the inactivation of Pygo2/Wnt signaling., PMID:38953488
Simultaneous screening of overexpressed genes in breast cancer for oncogenic drivers and tumor dependencies., PMID:38851782
PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma., PMID:38229324
Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain malignant progression in colon cancer., PMID:37423512
Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome., PMID:37349336
Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs., PMID:37233752
TSF/FHA induces osteogenic differentiation of Mc3t3 cells via Pygo2 dependent Wnt/β-catenin signaling pathway., PMID:37193170
A review on the role of SNHG8 in human disorders., PMID:37043963
Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer., PMID:36897957
Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients., PMID:36688188
Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2., PMID:36404439
Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway., PMID:35707871
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis., PMID:34362407
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes., PMID:33808143
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis., PMID:33643814
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism., PMID:33635162
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes., PMID:32727463
A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer., PMID:32586983
Lactobacillus species inhibitory effect on colorectal cancer progression through modulating the Wnt/β-catenin signaling pathway., PMID:32419125
Overexpression of Pygo2 Increases Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Cardiomyocyte-like Cells., PMID:31749426
PYGO2 as an independent diagnostic marker expressed in a majority of colorectal cancers., PMID:31492088
miR-516a-3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway., PMID:31273950
Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway., PMID:30279163
Contribution of KCTD12 to esophageal squamous cell carcinoma., PMID:30157793
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer., PMID:29769196
Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector., PMID:29719262
Ibuprofen reduces cell proliferation through inhibiting Wnt/β catenin signaling pathway in gastric cancer stem cells., PMID:29512256
PYGOPUS2 expression in prostatic adenocarcinoma is a potential risk stratification marker for PSA progression following radical prostatectomy., PMID:28924059
Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling., PMID:28815294
LncRNA625 modulates prostate cancer cells proliferation and apoptosis through regulating the Wnt/β-catenin pathway by targeting miR-432., PMID:28678327
Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells., PMID:28427190
Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9., PMID:28296634
A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation., PMID:28174279
Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer., PMID:28055972
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression., PMID:27811361
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans., PMID:27569725
Wnt/β-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members., PMID:27647933
Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2., PMID:27324116
Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment., PMID:26902498
Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway., PMID:26876203
Downregulation of Pygopus 2 inhibits vascular mimicry in glioma U251 cells by suppressing the canonical Wnt signaling pathway., PMID:26870266
Selective estrogen receptor modulators and betulinic acid act synergistically to target ERα and SP1 transcription factor dependent Pygopus expression in breast cancer., PMID:26645832
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia., PMID:26345837
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation., PMID:26170450
Increased Pygo2 expression in liver of patients with hepatitis B virus-related fibrosis., PMID:26013055
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives., PMID:25913844
Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression., PMID:25871475
For research use only. Not for human or drug use.
