Catalog No.
YHJ49101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg149-Lys268
Predicted molecular weight
14.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BRJ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Class C basic helix-loop-helix protein 5, bHLHc5, MESP1, Mesoderm posterior protein 1, BHLHC5
Sonic Hedgehog signaling regulates the optimal differentiation pace from early-stage mesoderm to cardiogenic mesoderm in mice., PMID:39783159
Enhancing cardiac regeneration: direct reprogramming of fibroblasts into myocardial-like cells using extracellular vesicles secreted by cardiomyocytes., PMID:39718680
FGF4 and ascorbic acid enhance the maturation of induced cardiomyocytes by activating JAK2-STAT3 signaling., PMID:39349833
The importance of matrix in cardiomyogenesis: Defined substrates for maturation and chamber specificity., PMID:39291079
JAK activity regulates mesoderm cell fate by controlling MESP1 expression., PMID:39182311
Human Genetics of Ventricular Septal Defect., PMID:38884729
Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics., PMID:37705079
Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues., PMID:37559144
MESP1-knockdown inhibits the proliferation and epithelial mesenchymal transition of hepatocellular carcinoma and enhances the tumor-suppressive effect of 5-fluorouracil., PMID:37271034
Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs., PMID:37233752
BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage., PMID:37082965
A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors., PMID:36994838
Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation., PMID:36670288
Alpha terpineol directs bone marrow mesenchymal stem cells toward neuronal lineage through regulation of wnt signaling pathway., PMID:36651266
STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development., PMID:36635482
Essential role of MESP1-RING1A complex in cardiac differentiation., PMID:36413948
Cardiac Development in the Presence of Cadmium: An in Vitro Study Using Human Embryonic Stem Cells and Cardiac Organoids., PMID:36321828
PPARγ and NOTCH Regulate Regional Identity in the Murine Cardiac Outflow Tract., PMID:36205127
Overexpression of PYGO1 promotes early cardiac lineage development in human umbilical cord mesenchymal stromal/stem cells by activating the Wnt/β-catenin pathway., PMID:36085540
Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors., PMID:35817961
Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts., PMID:35762944
Acentrosomal spindle assembly and maintenance in Caenorhabditis elegans oocytes requires a kinesin-12 nonmotor microtubule interaction domain., PMID:35594182
Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells., PMID:35414019
MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin., PMID:35246800
Transcription Factors - the Essence of Heart Regeneration: A Potential Novel Therapeutic Strategy., PMID:35170408
Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1., PMID:35025872
Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression., PMID:34806916
Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm., PMID:34789765
Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice., PMID:34679163
Soluble expression, purification, and secondary structure determination of human MESP1 transcription factor., PMID:33651130
Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy., PMID:33393499
Alterations of 5-hydroxymethylcytosines in circulating cell-free DNA reflect retinopathy in type 2 diabetes., PMID:33221518
Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation., PMID:33199445
Dual TGFβ and Wnt inhibition promotes Mesp1-mediated mouse pluripotent stem cell differentiation into functional cardiomyocytes., PMID:33048365
High levels of MESP1 expression in non-small cell lung cancer can facilitate cell proliferation, metastasis and suppresses cell apoptosis., PMID:35117208
3D Bioprinting the Cardiac Purkinje System Using Human Adipogenic Mesenchymal Stem Cell Derived Purkinje Cells., PMID:32710379
RYBP is important for cardiac progenitor cell development and sarcomere formation., PMID:32673370
Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair., PMID:32550911
Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability., PMID:32320395
Adverse effects of nicotine on cardiogenic differentiation from human embryonic stem cells detected by single-cell RNA sequencing., PMID:32276728
Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors., PMID:32129551
RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells., PMID:32098400
IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart., PMID:31949883
A Highly Conductive 3D Cardiac Patch Fabricated Using Cardiac Myocytes Reprogrammed from Human Adipogenic Mesenchymal Stem Cells., PMID:31916039
β-Adrenergic stimuli and rotating suspension culture enhance conversion of human adipogenic mesenchymal stem cells into highly conductive cardiac progenitors., PMID:31821703
Cardiopharyngeal Progenitor Specification: Multiple Roads to the Heart and Head Muscles., PMID:31818856
Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis., PMID:31761621
Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature., PMID:31719045
Optimized conditions for the supplementation of human-induced pluripotent stem cell cultures with a GSK-3 inhibitor during embryoid body formation with the aim of inducing differentiation into mesodermal and cardiac lineage., PMID:31615734
Single-cell RNA-seq analysis of Mesp1-induced skeletal myogenic development., PMID:31590918
For research use only. Not for human or drug use.
