Catalog No.
YHJ48001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala224-Tyr471
Predicted molecular weight
29.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99972
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MYOC, Myocilin, Trabecular meshwork-induced glucocorticoid response protein, GLC1A, TIGR, Myocilin 55 kDa subunit, Myocilin 35 kDa N-terminal fragment, Myocilin 20 kDa N-terminal fragment
Detection of non-native species formed during fibrillization of the myocilin olfactomedin domain., PMID:40095382
Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay., PMID:40081751
Evaluating Practical Approaches for Including MYOC Variants Alongside Common Variants for Genetics-Based Risk Stratification for Glaucoma., PMID:40064388
Identification and structural analysis of pathogenic variants in MYOC and CYP1B1 genes in Indian JOAG patients., PMID:39998747
Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork., PMID:39847376
Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma., PMID:39836483
Identification of mutation of MYOC (c.1099G>A), a pedigree pathogenic gene of juvenile open angle glaucoma (JOAG): A case report., PMID:39809167
Association between gene polymorphisms and glaucoma susceptibility among Africans: a systematic review and meta-analysis., PMID:39757584
Binding Interaction Between Two Mutant Myocilin Olfactomedin Domain Monomers in a Homodimer., PMID:39571175
A Mini-Review on Gene Therapy in Glaucoma and Future Directions., PMID:39456800
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome., PMID:39337505
Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals., PMID:39158757
Integrating Genetics in Glaucoma Screening., PMID:39149951
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma., PMID:38521856
Intraocular pressure across the lifespan of Tg-MYOCY437H mice., PMID:38453040
Somatic Mutations within Myocilin due to Aging May Be a Potential Risk Factor for Glaucoma., PMID:38397193
Molecular genetics of inherited normal tension glaucoma., PMID:38389252
Evaluation of Myocilin Variant Protein Structures Modeled by AlphaFold2., PMID:38275755
Myocilin Mutation N480K Leads to Early Onset Juvenile and Adult-onset Primary Open Angle Glaucoma in a Six Generation Family., PMID:37670504
Variable phenotypic expression of MYOC mutations in a family with inherited pediatric glaucoma., PMID:37247815
Myocilin misfolding and glaucoma: A 20-year update., PMID:37217093
COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children., PMID:36834493
Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability., PMID:36579626
A novel heterozygous c.733 T > G MYOC mutation associated with juvenile-onset open-angle glaucoma in a Chinese family., PMID:36543942
Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish., PMID:36077382
Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice., PMID:36069958
Calcium dysregulation potentiates wild-type myocilin misfolding: implications for glaucoma pathogenesis., PMID:35831671
A Simple Secretion Assay for Assessing New and Existing Myocilin Variants., PMID:35196929
Penetrance of MYOC gene mutation in primary open-angle glaucoma: A systematic review and meta-analysis., PMID:35014583
Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells., PMID:34896106
Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Associations with Polymorphisms in Protein Stabilities., PMID:34828408
CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma., PMID:34526297
Myocilin-associated Glaucoma: A Historical Perspective and Recent Research Progress., PMID:34497454
Molecular architecture and modifications of full-length myocilin., PMID:34400147
Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin., PMID:34384785
Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation., PMID:34299211
Gonioscopy-Assisted Transluminal Trabeculotomy for Myocilin Juvenile Glaucoma., PMID:34273563
Functional characterization of adult human trabecular meshwork stem cells., PMID:34174318
Common and rare myocilin variants: Predicting glaucoma pathogenicity based on genetics, clinical, and laboratory misfolding data., PMID:34082484
Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population., PMID:34081096
ITGA8 positive cells in the conventional outflow tissue exhibit Schlemm's canal endothelial cell properties., PMID:33961857
Molecular Insights into Myocilin and Its Glaucoma-Causing Misfolded Olfactomedin Domain Variants., PMID:33847483
Systemic Genotype-Phenotype Analysis of MYOC Variants Based on Exome Sequencing and Literature Review., PMID:33793440
Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank., PMID:33713785
Structural Arrangement within a Peptide Fibril Derived from the Glaucoma-Associated Myocilin Olfactomedin Domain., PMID:33683890
Isolation and characterization of novel primary cells from the human distal outflow pathway., PMID:33597641
Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin., PMID:33539326
A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling., PMID:33516765
Stem cell transplantation rescued a primary open-angle glaucoma mouse model., PMID:33506763
Prevalence of MYOC risk variants for glaucoma in different populations., PMID:33421356
For research use only. Not for human or drug use.
