Catalog No.
YHJ45801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly681-Glu936
Predicted molecular weight
30.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99683
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ASK1, MAPK/ERK kinase kinase 5, MEKK5, MAPKKK5, MEKK 5, Apoptosis signal-regulating kinase 1, ASK-1, Mitogen-activated protein kinase kinase kinase 5, MAP3K5, MEK kinase 5
Expression of PIM1/ASK1 Molecular Pathway Related Genes in Ischemic Cardiomyopathy., PMID:40511800
SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway., PMID:40510365
Age-related stress gene expression in neonatal sepsis involves regulatory networks and immune cell infiltration., PMID:40442112
Transcriptomic Profiling of Hypoxia-Adaptive Responses in Tibetan Goat Fibroblasts., PMID:40427283
NOD1 deficiency promotes inflammation via autophagic degradation of ASK1., PMID:40399666
Plasma proteome signatures of ASK1 inhibition by selonsertib associate with efficacy in the MOSAIC randomized trial for diabetic kidney disease., PMID:40375085
Transcriptome-based analysis reveals relationship between duck eggshell color and eggshell strength., PMID:40295915
Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK., PMID:40287113
Multiomic insight into the involvement of cell aging related genes in the pathogenesis of endometriosis., PMID:40269081
HPV16 E7 inhibits HBD2 expression by down-regulation of ASK1-p38 MAPK pathway in cervical cancer., PMID:40253372
ASK1 inhibition by selonsertib attenuates elastase-induced emphysema in mice., PMID:40189195
ASK1 limits kidney glucose reabsorption, growth, and mid-late proximal tubule KIM-1 induction when diabetes and Western diet are combined with SGLT2 inhibition., PMID:40152436
Identification and evaluation of cyclic urea based 4H-triazolo pyridine substituted derivatives as novel ASK1 inhibitors., PMID:40117753
Discovery of Novel Pyridin-2-yl Urea Inhibitors Targeting ASK1 Kinase and Its Binding Mode by Absolute Protein-Ligand Binding Free Energy Calculations., PMID:40003993
Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway., PMID:39906888
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance., PMID:39901302
Identification of potential targets regulating neutrophil extracellular traps in acute rejection of kidney transplantation based on transcriptomics and animal experiments., PMID:39756163
ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice., PMID:39488570
Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors., PMID:39431736
Reticulophagy and viral infection., PMID:39394962
Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights., PMID:39383866
Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy., PMID:39373232
Kaempferol attenuates cyclosporine-induced renal tubular injury via inhibiting the ROS-ASK1-MAPK pathway., PMID:39316086
Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway., PMID:39211547
Novel biomarkers associated with oxidative stress and immune infiltration in intervertebral disc degeneration based on bioinformatics approaches., PMID:39182249
Aerobic exercise modulates RIPK1-mediated MAP3K5/JNK and NF-κB pathways to suppress microglia activation and neuroinflammation in the hippocampus of D-gal-induced accelerated aging mice., PMID:39181380
Unveiling the anticancer potential of Pestalotioprolide E, an unexplored macrolide: Targeting TRXR1-TRX1-ASK1-P38 signaling cascade in triple-negative breast cancer., PMID:39173682
Promotion of Raf-1/ASK1 complex formation by corylin inhibits cell apoptosis in myocardial ischemia/reperfusion injury., PMID:39133953
Stress pathway outputs are encoded by pH-dependent clustering of kinase components., PMID:39103333
RING finger protein 5 protects against acute myocardial infarction by inhibiting ASK1., PMID:39098896
Therapeutic potential of ASK1 activators in cancer treatment: Current insights and future directions., PMID:39079264
Fe3O4-Coated CNTs-Gum Arabic Nano-Hybrid Composites Exhibit Enhanced Anti-Leukemia Potency Against AML Cells via ROS-Mediated Signaling., PMID:39055376
ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells., PMID:39054955
Comprehensive analysis of MAPK genes in the prognosis, immune characteristics, and drug treatment of renal clear cell carcinoma using bioinformatic analysis and Mendelian randomization., PMID:39038636
SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway., PMID:39008037
Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus Pulposus Cell Senescence and Apoptosis to Regulate Intervertebral Disc Degeneration., PMID:38879082
Targeting ASK1 by CS17919 alleviates kidney- and liver-related diseases in murine models., PMID:38873818
Reactions of Cisplatin with Thioredoxin-1 Regulate Intracellular Redox Homeostasis., PMID:38850241
Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging., PMID:38839869
The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity., PMID:38829910
ASK1 activation in glial cells in post-mortem multiple sclerosis tissue., PMID:38775061
Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway., PMID:38721693
Abrogating PDK4 activates autophagy-dependent ferroptosis in breast cancer via ASK1/JNK pathway., PMID:38678126
Exploring novel indazole derivatives as ASK1 inhibitors: Design, synthesis, biological evaluation and docking studies., PMID:38677010
Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway., PMID:38648762
Methylosome protein 50 is necessary for oogenesis in medaka., PMID:38432104
ASK1/ p38 axis inhibition blocks the release of mitochondrial "danger signals" from hepatocytes and suppresses progression to cirrhosis and liver cancer., PMID:38377458
Transcriptional and physiological profiles reveal the respiratory, antioxidant and metabolic adaption to intermittent hypoxia in the clam Tegillarca granosa., PMID:38359602
Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma., PMID:38229155
Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal-regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment., PMID:38172941
For research use only. Not for human or drug use.
