Catalog No.
YHJ44801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp356-Tyr595
Predicted molecular weight
30.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99572
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
P2RX7, Purinergic receptor, P2X purinoceptor 7, P2X7, P2Z receptor, ATP receptor
Uncovering the mechanism of Buyang Huanwu Decoction in regulating mitochondrial dysfunction to alleviate atherosclerosis: BTK, PREPL, and P2RX7 proteins play key roles., PMID:40494461
CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cells and macrophages via CITED2., PMID:40473221
From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression., PMID:40429831
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis., PMID:40371642
Basal and exercise-induced expression of NLRP3 inflammasome-related components is increased in patients with chronic coronary syndrome., PMID:40339359
Mechanistic insights into Alpha-Synuclein binding to P2RX7: A molecular dynamic and docking study., PMID:40315262
The P2X7R/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk., PMID:40279432
Protease-hydrolysis-driven approach towards the quantification of cellular mRNA after drug treatment in protein nanopores., PMID:40221202
Analysis of the Relationship Between NLRP3 and Alzheimer's Disease in Oligodendrocytes based on Bioinformatics and In Vitro Experiments., PMID:40207815
Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis., PMID:40128095
Visualization of P2X7 Receptors in Living Human Gliomas: An 18F-GSK1482160 PET Imaging and Neuropathology Study., PMID:40094419
Cyclic N, O-acetals and corresponding opened N, N-aminals as new scaffolds with promising anti-inflammatory and antifungal activities against Candida albicans., PMID:40069300
M6A Modified miR-31-5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7., PMID:40068094
P2X7 receptor augments kainic acid-induced nitrosative stress by abrogating GS-HSP25-mediated iNOS inhibition and GSH synthesis in the mouse hippocampus., PMID:40032027
cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia., PMID:40025497
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line., PMID:40024982
CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus., PMID:39995666
Mitochondrial ROS connects P2X7-mediated Ca2+ influx with IL-1α release by monocytes upon chronic tissue damage., PMID:39984250
The Purinergic Ligand-Gated Ion Channel 7 Receptor Promotes the Proliferation, Invasion, and Migration of Breast Cancer Cells., PMID:39967467
P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset., PMID:39957192
Impaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody., PMID:39940947
P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice., PMID:39886340
Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications., PMID:39869622
Transcriptome Analysis Suggests PKD3 Regulates Proliferative Glucose Metabolism, Calcium Homeostasis and Microtubule Dynamics After MEF Spontaneous Immortalization., PMID:39859313
The Anti-Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement-Dependent Cytotoxicity of Human Leukocytes., PMID:39853757
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis., PMID:39802756
Investigation of Oxidative-Stress Impact on Human Osteoblasts During Orthodontic Tooth Movement Using an In Vitro Tension Model., PMID:39769290
Role of P2X7 receptor in the progression and clinicopathological characteristics of gastric cancer., PMID:39738256
Analysis of regulatory patterns of NLRP3 corpuscles and related genes and the role of macrophage polarization in atherosclerosis based on online database., PMID:39725776
Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy., PMID:39693800
Saikosaponins from Bupleurum scorzonerifolium Willd. alleviates microglial pyroptosis in depression by binding and inhibiting P2X7 expression., PMID:39637473
Retinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players., PMID:39626856
The role and mechanism of P2X7R in cirrhotic cardiomyopathy., PMID:39577339
Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in chronic kidney disease in a reactive oxygen species-dependent manner., PMID:39571908
Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling., PMID:39560665
An unconventional purine connection., PMID:39560664
Hypercapnia promotes NLRP3 inflammasome activation in microglia by activating P2X7R after lipopolysaccharide-induced activation of the TLR4/NF-κB signaling pathway., PMID:39549469
Transcriptomic alterations in APP/PS1 mice astrocytes lead to early postnatal axon initial segment structural changes., PMID:39485512
Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study., PMID:39468243
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior., PMID:39425818
Exploring P2X7 receptor antagonism as a therapeutic target for neuroprotection in an hiPSC motor neuron model., PMID:39419765
P2X7 receptors modulate acquisition of cue fear extinction and contextual background memory generalization in male mice., PMID:39366651
Inflammasome activation aggravates choroidal neovascularization., PMID:39316206
Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model., PMID:39300576
P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus., PMID:39269925
Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain of Toxoplasma gondii., PMID:39267751
Letter: Further nuanced data on the role of P2RX7 SNPs in chronic pain states., PMID:39230526
Inhibition of P2RX7 contributes to cytotoxicity by suppression of glycolysis and AKT activation in human hepatocellular carcinoma., PMID:39219047
An improved understanding of pediatric chronic nonbacterial osteomyelitis pathophysiology informs current and future treatment., PMID:39209330
Increased Pan-Type, A1-Type, and A2-Type Astrocyte Activation and Upstream Inflammatory Markers Are Induced by the P2X7 Receptor., PMID:39201471
For research use only. Not for human or drug use.
