Catalog No.
YHJ44301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro19-His432
Predicted molecular weight
49.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99538
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRSC1, Legumain, Asparaginyl endopeptidase, LGMN, Protease, cysteine 1
Transcriptome and proteome profile analysis of the regulation of chicken ovarian development., PMID:40466268
Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia., PMID:40234537
Soluble-microneedle enhance three T-cell activation signals as efficient tumor vaccines for melanoma prevention and treatment., PMID:40233828
Legumain In Situ Engineering Promotes Efferocytosis of CAR Macrophage to Treat Cardiac Fibrosis., PMID:40223483
Predictive potential of combined secretomics and image-based morphometry as a non-invasive method for selecting implanting embryos., PMID:40221726
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway., PMID:40211281
Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical models., PMID:40131864
Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice., PMID:39739031
Legumain deficiency halts atherogenesis by modulating T cell receptor signaling., PMID:39473192
Proteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins., PMID:39389361
Legumain/asparaginyl endopeptidase-resistant tau fibril fold produces corticobasal degeneration-specific C-terminal tau fragment., PMID:39353514
Integrated multi-omic high-throughput strategies across-species identified potential key diagnostic, prognostic, and therapeutic targets for atherosclerosis under high glucose conditions., PMID:39223351
Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer., PMID:39097734
Investigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma., PMID:38980440
Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis., PMID:38947504
Quantitative proteomics reveals cellular responses to individual mAb expression and tunicamycin in CHO cells., PMID:38896138
Four-Dimensional Label-Free Quantitative Proteomics of Ginsenoside Rg2 Ameliorated Scopolamine-Induced Memory Impairment in Mice through the Lysosomal Pathway., PMID:38885433
Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity., PMID:38815795
Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia., PMID:38677698
Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R., PMID:38331907
The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice., PMID:38201240
Pigmented Microbial Extract (PMB) from Exiguobacterium Species MB2 Strain (PMB1) and Bacillus subtilis Strain MB1 (PMB2) Inhibited Breast Cancer Cells Growth In Vivo and In Vitro., PMID:38139241
Immune modulation of goat monocytes by Fasciola gigantica Legumain-1 protein (Fg-LGMN-1)., PMID:38081528
CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6., PMID:38047378
The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure., PMID:37978185
Weighted gene co-expression network analysis and machine learning identified the lipid metabolism-related gene LGMN as a novel biomarker for keloid., PMID:37930112
Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy., PMID:37895091
Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma., PMID:37858339
Integrated multi-omics reveals the beneficial role of chlorogenic acid in improving the growth performance and immune function of immunologically stressed broilers., PMID:37635925
The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity., PMID:37584546
Downregulation of lysosomal trafficking in ARPE19 cells leads to decreased transfection efficiency at high passage., PMID:37546846
Accumulation of plasmacytoid dendritic cell is associated with a treatment response to DNA-damaging treatment and favorable prognosis in lung adenocarcinoma., PMID:37435086
Integrated analysis of methylation profiles and transcriptome of Marek's disease virus-infected chicken spleens reveal hypomethylation of CD4 and HMGB1 genes might promote Marek's disease tumorigenesis., PMID:37043960
NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells., PMID:37002649
Role of LGMN in tumor development and its progression and connection with the tumor microenvironment., PMID:36825203
Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis., PMID:36551281
The Heterogeneity of Tumour-Associated Macrophages Contributes to the Recurrence and Outcomes of Glioblastoma Patients., PMID:36542317
DAP12 deletion causes age-related motor function impairment but promotes functional recovery after sciatic nerve crush injury., PMID:36503041
Metformin regulates autophagy via LGMN to inhibit choriocarcinoma., PMID:36464174
A review on the role of PCGEM1 lncRNA in cancer., PMID:36403313
Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas., PMID:36232358
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma., PMID:36041510
Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3., PMID:35854065
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF., PMID:35820705
Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers., PMID:35625736
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma., PMID:35413115
Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression., PMID:35353567
Expression of extracellular matrix proteins nidogen-1 and legumain in endometrial carcinomas., PMID:35128760
Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture., PMID:35100526
Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene., PMID:35053409
For research use only. Not for human or drug use.
