Catalog No.
YHJ43501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp1715-Lys2002
Predicted molecular weight
31.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99466
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NOTCH4, INT3, hNotch4, Neurogenic locus notch homolog protein 4, Notch 4
Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk., PMID:40514331
A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort., PMID:40427057
Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming., PMID:40272637
ADAMTSL2 is an independent predictor for the prognosis of gastric cancer., PMID:40252157
STEAP4 facilitates growth, migration, and invasion of prostate carcinoma through upregulation of NOTCH4., PMID:40171963
Update on the nature of central giant cell granuloma of the jaw with a focus on the aggressive subtype., PMID:39952878
NOTCH1, 2, and 3 receptors enhance osteoblastogenesis of mesenchymal C3H10T1/2 cells and inhibit this process in preosteoblastic MC3T3-E1 cells., PMID:39879823
Integrative Analyses of Biomarkers and Pathways in Oxidative Stress-Related Genes for Gestational Diabetes Mellitus., PMID:39876591
Identification of Drug-Targetable Genes for Eczema and Dermatitis Using Integrated Genomic and Proteomic Approaches., PMID:39786806
Identification of Biomarkers and Molecular Pathways Implicated in Smoking and COVID-19 Associated Lung Cancer Using Bioinformatics and Machine Learning Approaches., PMID:39595659
CD90's role in vascularization and healing of rib fractures: insights from Dll4/notch regulation., PMID:39455438
Notch4 regulatory T cells and SARS-CoV-2 viremia shape COVID19 survival outcome., PMID:39361431
Sustainability of shear stress conditioning in endothelial colony-forming cells compared to human aortic endothelial cells to underline suitability for tissue-engineered vascular grafts., PMID:39278537
Exploring SALL4 as a significant prognostic marker in breast cancer and its association with progression pathways involved in cancer genesis., PMID:39098137
General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway., PMID:39074180
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium., PMID:38984877
Antioxidant and neurodevelopmental gene polymorphisms in prematurely born individuals influence hypoxia-related oxidative stress., PMID:38942829
[The Role of Notch Signaling Pathway in Adult Patients with Epstein-Barr Virus-induced Infectious Mononucleosis]., PMID:38926989
MiR-33a Overexpression Exacerbates Diabetic Nephropathy Through Sirt6-dependent Notch Signaling., PMID:38904337
N-phenyl pyrazoline derivative inhibits cell aggressiveness and enhances paclitaxel sensitivity of triple negative breast cancer cells., PMID:38851778
Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition., PMID:38811818
Mechanoresponsive ETS1 causes endothelial dysfunction and arterialization in varicose veins via NOTCH4/DLL4 signaling., PMID:38759515
Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma., PMID:38654358
Upregulation of Notch Signaling and Cell-Differentiation Inhibitory Transcription Factors in Stable Chronic Obstructive Pulmonary Disease Patients., PMID:38542260
Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome., PMID:38502427
CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells., PMID:38418926
NCoR1 limits angiogenic capacity by altering Notch signaling., PMID:38359551
Notch signaling and targeted therapy in non-small cell lung cancer., PMID:38301911
The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control., PMID:38146367
Construction of a risk stratification model integrating ctDNA to predict response and survival in neoadjuvant-treated breast cancer., PMID:38087296
Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization., PMID:37961223
T regulatory lymphocytes specific for SARS-CoV-2 display increased functional plasticity., PMID:37827267
NOTCH Pathway Genes in Ovarian Cancer: Clinical Significance and Associations with Immune Cell Infiltration., PMID:37796700
Comprehensive Analysis of Ligand-receptor Interactions in Colon Adenocarcinoma to Identify of Tumor Microenvironment Oxidative Stress and Prognosis Model., PMID:37605402
Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort., PMID:37544578
NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis., PMID:37478314
An investigation into the role of Notch signaling, altered angiogenesis, and inflammatory-induced preterm delivery and related complications in Northeast Indian patients., PMID:37421871
Epigenome-wide association study identifies Vogt-Koyanagi-Harada disease-associated DNA methylation loci in Chinese., PMID:37394087
Deep proteome investigation of high-grade gliomas reveals heterogeneity driving differential metabolism of 5-aminolevulinic acid., PMID:37358939
NOTCH4ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1., PMID:37268635
Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42., PMID:37149651
The Clinical Application of Immunohistochemical Expression of Notch4 Protein in Patients with Colon Adenocarcinoma., PMID:37108670
DNA methylation patterns suggest the involvement of DNMT3B and TET1 in osteosarcoma development., PMID:37020053
Clinical significance of Notch receptors in triple negative breast cancer., PMID:36970890
Identification of tumor mutation burden-associated molecular and clinical features in cancer by analyzing multi-omics data., PMID:36911742
Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis., PMID:36817473
NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population., PMID:36724752
Bioinformatic analysis of single-cell RNA sequencing dataset dissects cellular heterogeneity of triple-negative breast cancer in transcriptional profile, splicing event and crosstalk network., PMID:36692641
Immunology of Giant Cell Arteritis., PMID:36656970
For research use only. Not for human or drug use.
