Catalog No.
YHJ42101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu211-Gln486
Predicted molecular weight
34.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96RI1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR1, RXR-interacting protein 14, BAR, FXR, Bile acid receptor, NR1H4, RIP14, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14
Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks., PMID:40458398
Lactobacillus rhamnosus GG maintains gut microbiota stability and promotes intestinal adaptation via activated intestinal farnesoid X receptor signaling in short bowel syndrome., PMID:40425822
GPR146 regulates CYP7A1 transcription in cells and in vivo of mice., PMID:40414012
Changes in the FXR-cistrome and alterations in bile acid physiology in Wilson disease., PMID:40408300
Hepatoprotective effects of dandelion against AFB1-induced liver injury are associated with activation of bile acid-FXR signaling in chicks., PMID:40404059
Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction., PMID:40399878
Clostridium butyricum protects the ileal barrier in mice by regulating the farnesoid X receptor signaling pathway., PMID:40398713
Immunohistochemistry in Progressive Familial Intrahepatic Cholestasis (PFIC): Bridging Gap Between Morphology and Genetics., PMID:40384941
Deletion of hepatic FXR leads to more severe MASH development in female mice., PMID:40377496
Farnesoid X receptor‑driven metabolic plasticity: Bridging physiological adaptation and malignant transformation in lipid handling (Review)., PMID:40376981
Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids., PMID:40367952
Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5., PMID:40362481
Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression., PMID:40362260
[Fresh Rehmanniae Radix regulates cholesterol metabolism disorder in mice fed with high-fat and high-cholesterol diet via FXR-mediated bile acid reabsorption]., PMID:40350954
[Two new sesquiterpenoids from Aucklandiae Radix and their farnesoid X receptor agonist activity]., PMID:40350873
Calycosin regulates gut microbiota-bile acid-FXR axis to protect rats from cerebral ischemia-reperfusion injury., PMID:40348321
Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice., PMID:40338063
FXR protects against neonatal sepsis by enhancing the immunosuppressive function of MDSCs., PMID:40335739
Salvianolic acid B attenuates hypercholesterolemia via modulating the gut microbiota and bile acid metabolism., PMID:40334726
Ultrasound-driven ROS-scavenging nanobubbles for synergistic NASH treatment via FXR activation., PMID:40318601
The role of gut microbiota on skeletal muscle strength in LDLR knockdown aging mice., PMID:40312444
Cholestasis in hepatitis E virus infection., PMID:40308815
Gut-vascular barrier mediated Tripterygium wilfordii-induced liver injury: the synergism between triptolide and celastrol via intestinal FXR-ET-1 pathway., PMID:40306497
Natural bioactive compounds reprogram bile acid metabolism in MAFLD: Multi-target mechanisms and therapeutic implications., PMID:40306110
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INT-787, a Novel Farnesoid X Receptor Agonist, in Healthy Volunteers: A Phase 1 Trial., PMID:40304628
[Tuihuang Mixture improves α‑naphthylisothiocyanate-induced cholestasis in rats by inhibiting NLRP3 inflammasomes via regulating farnesoid X receptor]., PMID:40294921
FXR as a pivotal role linking JNK and G0s2 mitigates triptolide-induced hepatotoxicity through the regulation of metabolic disorder of liver., PMID:40288593
Gut microbiota regulates hepatic ketogenesis and lipid accumulation in ketogenic diet-induced hyperketonemia by disrupting bile acid metabolism., PMID:40268803
Farnesoid X receptor agonist accelerates ammonium metabolism of mesenchymal stem cell-derived hepatocyte-like cells., PMID:40268456
Uncovering mechanism of hepatotoxicity diseases caused by tetrahydrocannabinol based on novel network toxicology and experimental verification., PMID:40258948
Gut Microbiota and Its Metabolite Taurine-β-Muricholic Acid Contribute to Antimony- and/or Copper-Induced Liver Inflammation., PMID:40244173
Lactococcus petauri LZys1 modulates gut microbiota, diminishes ileal FXR-FGF15 signaling, and regulates hepatic function., PMID:40243350
Exploring the Mechanisms of the Antioxidants BHA, BHT, and TBHQ in Hepatotoxicity, Nephrotoxicity, and Neurotoxicity from the Perspective of Network Toxicology., PMID:40238193
Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation., PMID:40234449
Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis., PMID:40218932
Discovery of farnesoid X receptor antagonists from Salvia miltiorrhiza based on virtual screening and activity verification., PMID:40199406
Farnesoid X Receptor Regulated Sepsis-Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway., PMID:40192065
Short-chain fatty acids alleviate cholestatic liver injury by improving gut microbiota and bile acid metabolism., PMID:40186906
Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling., PMID:40179178
Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders., PMID:40169227
Beta-catenin/sirtuin 1/farnesoid X receptor pathway promotion of portal vein ligation and parenchymal transection-induced rapid liver regeneration., PMID:40157124
CYP3A Genotype Is Associated With Variability in the Exposure and Clearance of the Novel Oncogenic Transcription Inhibitor Lurbinectedin., PMID:40146606
Non-Steroidal FXR Agonistic Dimeric 2-Methyl-4-(1-glycerol)furan with Lipid-Lowering Activities from Marine-Derived Nocardiopsis sp. ZSN1., PMID:40137278
Gut microbiota-derived UDCA enhanced by metformin inhibits FXR to activate autophagy against MCD diet-induced NAFLD in mice., PMID:40121741
β-Sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo., PMID:40120651
Salidroside attenuates NASH through regulating bile acid-FXR/TGR5 signaling pathway via targeting gut microbiota., PMID:40118401
Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice., PMID:40097102
Structural insights into molecular and cellular level FXR binding potentials of GW4064 and LY2562175 hybrids by multi in silico modelling analyses., PMID:40095214
Zinc-Mediated Deacetylation of Farnesoid X Receptor Activates the Adipose Triglyceride Lipase Pathway to Reduce Hepatic Lipid Accumulation and Enhance Lipolysis in Yellow Catfish., PMID:40089111
Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex., PMID:40082595
For research use only. Not for human or drug use.
