Catalog No.
YHJ41901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu133-Leu411
Predicted molecular weight
34.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96Q04
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lemur tyrosine kinase 3, LMTK3, KIAA1883, TYKLM3, Serine/threonine-protein kinase LMTK3
LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer., PMID:40405280
Identification of homer protein homolog 3 as a prognostic marker of colon adenocarcinoma., PMID:39035486
The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl- extrusion., PMID:38715938
Chemoinformatics and machine learning techniques to identify novel inhibitors of the lemur tyrosine kinase-3 receptor involved in breast cancer., PMID:38638686
Proteomic analysis of anti-aging effects of Dendrobium nobile Lindl. alkaloids in aging-accelerated SAMP8 mice., PMID:37150330
Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer., PMID:36921601
The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor., PMID:36614307
Development of a risk model based on immune genes in patients with colon adenocarcinoma., PMID:36058633
Diving into the dark kinome: lessons learned from LMTK3., PMID:34819628
Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α., PMID:34745935
The multifaceted role of lemur tyrosine kinase 3 in health and disease., PMID:34582708
Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway., PMID:34516351
LMTK3 inhibition affects microtubule stability., PMID:33731143
AKT1 Polymorphism (rs10138227) and Risk of Colorectal Cancer in Moroccan Population: A Case Control Study., PMID:33247671
Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes., PMID:33192291
The structure-function relationship of oncogenic LMTK3., PMID:33188023
LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway., PMID:32865871
Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma., PMID:32336043
Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase., PMID:32192797
Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking., PMID:31310731
Molecular screening and docking analysis of LMTK3and AKT1 combined inhibitors., PMID:31223209
The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1., PMID:30944027
The LMTK-family of kinases: Emerging important players in cell physiology and pathogenesis., PMID:30597196
LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma., PMID:30242244
Structure-Based Virtual Screening of High-Affinity ATP-Competitive Inhibitors Against Human Lemur Tyrosine Kinase-3 (LMTK3) Domain: A Novel Therapeutic Target for Breast Cancer., PMID:30066129
Identification of curcumin derivatives as human LMTK3 inhibitors for breast cancer: a docking, dynamics, and MM/PBSA approach., PMID:29719770
LMTK3 confers chemo-resistance in breast cancer., PMID:29540829
Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways., PMID:28848113
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion., PMID:28294115
LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer., PMID:28260052
Designing and optimization of novel human LMTK3 inhibitors against breast cancer - a computational approach., PMID:27056562
LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5., PMID:26739063
LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer., PMID:26212333
An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling., PMID:25962159
Serum lemur tyrosine kinase-3: a novel biomarker for screening primary non-small cell lung cancer and predicting cancer progression., PMID:25755755
Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer., PMID:25287073
Transcriptional CCND1 expression as a predictor of poor response to neoadjuvant chemotherapy with trastuzumab in HER2-positive/ER-positive breast cancer., PMID:25200445
High expression of LMTK3 is an independent factor indicating a poor prognosis in estrogen receptor α-positive breast cancer patients., PMID:25163465
Targeting lemurs against cancer metastasis., PMID:25114035
Prognostic role of lemur tyrosine kinase 3 in postoperative gastric cancer., PMID:25054042
The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin β₁., PMID:24939894
LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking., PMID:24760852
Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer., PMID:24695631
Structural modeling and molecular dynamics studies on the human LMTK3 domain and the mechanism of ATP binding., PMID:24619340
Preoperative serum LMTK3 as a novel biomarker in non-small cell lung cancer., PMID:24510346
Endocrine resistance in breast cancer., PMID:24245601
Serum lemur tyrosine kinase 3 expression in colorectal cancer patients predicts cancer progression and prognosis., PMID:24174317
MicroRNA-34a suppresses cell proliferation by targeting LMTK3 in human breast cancer mcf-7 cell line., PMID:24050776
Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States., PMID:23918832
LMTK3 is implicated in endocrine resistance via multiple signaling pathways., PMID:22869149
For research use only. Not for human or drug use.
