Catalog No.
YHJ41701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys292
Predicted molecular weight
35.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96PP9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GBP4, Guanine nucleotide-binding protein 4, Guanylate-binding protein 4, GBP-4, GTP-binding protein 4
Regulatory effects of lncRNA PVT1 on transcriptome in human breast cancer MDA-MB-231 cell line determined by in silico analyses., PMID:40464801
Genetic Variants of GBP4: Reduced Risks for Drug-Induced Acute Liver Failure in Non-Finnish European Population., PMID:39868816
YTHDF1-mediated m6A modification of GBP4 promotes M1 macrophage polarization in acute lung injury., PMID:39806403
Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers., PMID:38471085
Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions., PMID:38348040
Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors., PMID:38347243
Multi-omics analyses of choroid plexus carcinoma cell lines reveal potential targetable pathways and alterations., PMID:38190092
The effect of TLR3 priming conditions on MSC immunosuppressive properties., PMID:38031182
Construction of a novel prognostic model in skin cutaneous melanoma based on chemokines-related gene signature., PMID:37875556
A diagnostic model based on gene biomarkers for Crohn's disease., PMID:37449318
Multi-omics analysis of Siglec family genes in cutaneous melanoma., PMID:37207210
Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation., PMID:37014865
Comparative study of GBP recruitment on two cytosol-dwelling pathogens, Francisella novicida and Shigella flexneri highlights differences in GBP repertoire and in GBP1 motif requirements., PMID:37012222
Positive regulation of innate immune response by miRNA-let-7a-5p., PMID:36685889
Whole Transcriptomic Analysis of Key Genes and Signaling Pathways in Endogenous ARDS., PMID:36246560
[Transcriptional Modification and Potential Intracellular Signaling Mechanisms in Human Macrophages Primed by Interferon-γ]., PMID:36208271
Multi-OMICs data analysis identifies molecular features correlating with tumor immunity in colon cancer., PMID:35213358
Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis., PMID:35179710
Protein expression of prognostic genes in primary melanoma and benign nevi., PMID:34757537
The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma., PMID:34487971
The impact of gene-body H3K36me3 patterns on gene expression level changes in chronic myelogenous leukemia., PMID:34352296
Identification of prognostic genes and construction of a novel gene signature in the skin melanoma based on the tumor microenvironment., PMID:34032721
Comparison of the Ability of High and Low Virulence Strains of Non-cytopathic Bovine Viral Diarrhea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium., PMID:33898551
Evolution of the guanylate binding protein (GBP) genes: Emergence of GBP7 genes in primates and further acquisition of a unique GBP3 gene in simians., PMID:33550067
Identification of immune-related genes with prognostic significance in the microenvironment of cutaneous melanoma., PMID:33179141
Development of an IFNγ response-related signature for predicting the survival of cutaneous melanoma., PMID:32902917
Prognostic and predictive value of immune/stromal-related gene biomarkers in renal cell carcinoma., PMID:32565957
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms., PMID:32541830
NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNγ Induced Genes., PMID:32265897
Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: A multicentre, prospective study., PMID:31378695
WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance., PMID:31276698
Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells., PMID:31026287
Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo., PMID:30696909
Integrating CNVs into meta-QTL identified GBP4 as positional candidate for adult cattle stature., PMID:29737453
Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma., PMID:29725478
Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility., PMID:29233899
Interferon regulated gene (IRG) expression-signature in a mouse model of chikungunya virus neurovirulence., PMID:29067635
GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8., PMID:29024643
Acute bovine viral diarrhea virus infection inhibits expression of interferon tau-stimulated genes in bovine endometrium., PMID:28605413
Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins., PMID:27363812
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment., PMID:26965581
Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology., PMID:24336069
Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis., PMID:23029268
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor., PMID:22754043
Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7., PMID:22095711
For research use only. Not for human or drug use.
