Catalog No.
YHJ40001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly399-Pro552
Predicted molecular weight
19.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96JB6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LOXC, Lysyl oxidase-related protein C, Lysyl oxidase-like protein 4, Lysyl oxidase homolog 4, LOXL4
A model of basement membrane-related regulators for prediction of prognoses in esophageal cancer and verification in vitro., PMID:40234833
Bortezomib suppresses TGF-β1-mediated LOXL4 reduction through the inhibition of MEK/ERK pathways in MDA-MB-231 cells., PMID:39862152
Lysyl oxidase inhibitors in colorectal cancer progression., PMID:39675250
Family-based whole-exome sequencing implicates a variant in lysyl oxidase like 4 in atypical femur fractures., PMID:39485938
The dual role of LOXL4 in the pathogenesis and development of human malignant tumors: a narrative review., PMID:38737700
Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface., PMID:38595825
Comprehensive Analysis of the Associations of LOXL1-4 with Prognosis and Immune Infiltration in Breast Cancer., PMID:38518152
Pan-Cancer Analysis of the LOX Family Reveals that LOX Affects Tumor Prognosis by Affecting Immune Infiltration., PMID:38073445
LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis., PMID:38047403
The possibilities of LOXL4 as a prognostic marker for carcinomas., PMID:37814029
The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis., PMID:37510994
Epigenetic and Tumor Microenvironment for Prognosis of Patients with Gastric Cancer., PMID:37238607
LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung., PMID:37235663
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles., PMID:37127706
Multifunctional Lysyl Oxidases., PMID:37047014
Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells., PMID:36949528
Overview of the miR-29 family members' function in breast cancer., PMID:36652981
Pyroptosis, apoptosis, and necroptosis molecular subtype derived prognostic signature universal applicable for gastric cancer-A large sample and multicenter retrospective analysis., PMID:36044785
Differential roles for lysyl oxidase (like), family members in chronic obstructive pulmonary disease; from gene and protein expression to function., PMID:35670745
Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy., PMID:35563478
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification., PMID:35433829
Long non-coding RNA AGAP2-AS1 promotes cell proliferation and invasion through regulating miR-193a-3p/LOXL4 axis in laryngeal squamous cell carcinoma., PMID:35113007
Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals., PMID:34852643
LAMA2 and LOXL4 are candidate FSGS genes., PMID:34565340
Polymorphisms in Lysyl Oxidase Family Genes Are Associated With Intracranial Aneurysm Susceptibility in a Chinese Population., PMID:34393991
The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection., PMID:34307505
LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice., PMID:33807332
Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer., PMID:33757755
Collagen type 1A1, type 3A1, and LOXL1/4 polymorphisms as risk factors of pelvic organ prolapse., PMID:33413618
Lysyl Oxidase-Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis., PMID:33068461
The prognostic value of the lysyl oxidase family in ovarian cancer., PMID:33058284
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer., PMID:32754259
In silico identification of the prognostic biomarkers and therapeutic targets associated with cancer stem cell characteristics of glioma., PMID:32725165
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy., PMID:32693113
YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate., PMID:32623954
Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data., PMID:32596059
Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation., PMID:32426343
Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy., PMID:32297656
Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis., PMID:32176358
Down-regulation of MBNL1-AS1 contributes to tumorigenesis of NSCLC via sponging miR-135a-5p., PMID:32092823
Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues., PMID:31705627
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer., PMID:31340433
The analyses of SRCR genes based on protein-protein interaction network in esophageal squamous cell carcinoma., PMID:31217847
Downregulation of lysyl oxidase-like 4 LOXL4 by miR-135a-5p promotes lung cancer progression in vitro and in vivo., PMID:30993701
Clinical significance of LOXL4 expression and features of LOXL4-associated protein-protein interaction network in esophageal squamous cell carcinoma., PMID:30900087
Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53., PMID:30728460
Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis., PMID:30704479
miR-210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting lysyl oxidase-like 4., PMID:30633357
Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues., PMID:30568176
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes., PMID:30510157
For research use only. Not for human or drug use.
