Catalog No.
YHJ39901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys45-Val397
Predicted molecular weight
41.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96JA1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LIG-1, Leucine-rich repeats and immunoglobulin-like domains protein 1, LIG1, LRIG1
Retraction: hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma., PMID:40438511
Hsa-miR-21 promoted the progression of lung adenocarcinoma by regulating LRIG1 expression., PMID:40269842
Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1 Expression During Salivary Gland Development., PMID:39587709
Proteome-wide Mendelian randomization provides novel insights into the pathogenesis and druggable targets of osteoporosis., PMID:39526243
MicroRNA-218-5p accelerates malignant behaviors of breast cancer through LRIG1., PMID:39491279
Application of mass cytometry in multiparametric characterization of precancerous cervical lesions., PMID:39462866
Cytarabine chemotherapy induces meibomian gland dysfunction., PMID:39395739
Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors., PMID:39250533
Regenerative Role of Lrig1+ Cells in Kidney Repair., PMID:39120954
LRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways., PMID:38987622
Exosomal miR-19a derived from melanoma cell promotes the vemurafenib resistance of malignant melanoma through directly targeting LRIG1 to reactivate AKT and MAPK pathway., PMID:38955119
Immunoreactivity of LMO7 and other molecular markers as potential prognostic factors in oropharyngeal squamous cell carcinoma., PMID:38918827
HPV8-induced STAT3 activation led keratinocyte stem cell expansion in human actinic keratoses., PMID:38916963
Preservation of 5-Hydroxymethylcytosine Levels in LRIG1 across Genomic DNA and Cell-Free DNA in Glioma Patients., PMID:38790164
LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses., PMID:38758807
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma., PMID:38454507
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is downregulated in Invasive ductal carcinoma and potential prognostic marker of breast cancer., PMID:38376291
Urban Particulate Matter Triggers Meibomian Gland Dysfunction., PMID:38315493
Dynamic tuft cell expansion during gastric metaplasia and dysplasia., PMID:38117182
An oncogenic phenoscape of colonic stem cell polarization., PMID:38065080
Lrig1 drives cryptogenesis and restrains proliferation during colon development., PMID:37873577
Identification of mitochondria-related action targets of quercetin in melanoma cells., PMID:37869567
Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis., PMID:37666819
Ligand-specific regulation of transforming growth factor beta superfamily factors by leucine-rich repeats and immunoglobulin-like domains proteins., PMID:37603563
FoxC1 activates limbal epithelial stem cells following corneal epithelial debridement., PMID:37488009
Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer., PMID:37357017
Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate., PMID:37330071
A member of the immunoglobulin superfamily lrig-1 might be involved in the immune priming of Scylla paramamosain in response to the infection and re-infection by Vibrio parahaemolyticus., PMID:37302729
Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome., PMID:37212950
Recurrent PAK2 rearrangements in poroma with folliculo-sebaceous differentiation., PMID:37199682
Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines., PMID:37185361
The effect of 1,25-dihydroxyvitamin D3 on the Wnt signaling pathway in bovine intestinal epithelial cells is mediated by the DKK2 (dickkopf2) Wnt antagonist., PMID:37149202
Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche., PMID:36899019
KRAS G12D mutation in Brunner gland adenoma., PMID:36707100
Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation., PMID:36631891
Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells., PMID:36420140
Single-molecule array assay reveals the prognostic impact of plasma LRIG1 in ovarian carcinoma., PMID:36326616
HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?, PMID:35969315
Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis., PMID:35815643
Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer., PMID:35743714
Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer., PMID:35440669
Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development., PMID:35196485
Mechanisms modulating the activities of intestinal stem cells upon radiation or chemical agent exposure., PMID:35021216
Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle., PMID:34929175
Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation., PMID:34576152
hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma., PMID:34532379
Cutaneous Effects of In Utero and Lactational Exposure of C57BL/6J Mice to 2,3,7,8-Tetrachlorodibenzo-p-dioxin., PMID:34437510
Lrig1 expression identifies airway basal cells with high proliferative capacity and restricts lung squamous cell carcinoma growth., PMID:34385275
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation., PMID:34338291
LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers., PMID:34331569
For research use only. Not for human or drug use.
