Catalog No.
EHJ37701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Gly422
Predicted molecular weight
47.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96B86
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A
Virus-induced RGMa expression drives neurodegeneration in HTLV-1-associated myelopathy., PMID:40305434
Repulsive Guidance Molecule-A as a Therapeutic Target Across Neurological Disorders: An Update., PMID:40244061
The risk of stroke-related pneumonia: a systematic review of peripheral immunodepression markers., PMID:40110857
Pilot Exploration of RGMa-BMP4 Signaling in Neutrophil Activation in NMOSD: Integrating Clinical and Molecular Insights., PMID:40087219
Inhibition of repulsive guidance molecule A ameliorates diabetes-induced cognitive decline and hippocampal neurogenesis impairment in mice., PMID:39972167
The potential role of RhoA/ROCK-inhibition on locomotor recovery after spinal cord injury: a systematic review of in-vivo studies., PMID:39956860
The expression of repulsive guidance molecule a in the rat brain and the diffusion tensor imaging evaluation for crossed cerebellar diaschisis., PMID:39871792
Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis., PMID:39663263
The role of H3K27 acetylation in oxygen-glucose deprivation-induced spinal cord injury and potential for neuroprotective therapies., PMID:39643249
Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice., PMID:39613526
Artificial Microglia Nanoplatform Loaded With Anti-RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke., PMID:39475454
Development and validation of an ultra-performance liquid chromatography with tandem mass spectrometry method for determination of soluble repulsive guidance molecule A in human serum and cerebrospinal fluid., PMID:39387340
Large scale serum proteomics identifies proteins associated with performance decline and clinical milestones in Duchenne muscular dystrophy., PMID:39148831
Long non-coding RNA SNHG12 regulates leptomeningeal collateral remodeling via RGMa after ischemic stroke., PMID:39138027
Protein biomarker signature in patients with spinal and bulbar muscular atrophy., PMID:38973610
Associations between multiple neurological biomarkers and distal sensorimotor polyneuropathy: KORA F4/FF4 study., PMID:38872492
Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis., PMID:38775562
Circular RNA circHIPK2 inhibits colon cancer cells through miR-373-3p/RGMA axis., PMID:38762192
Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism., PMID:38556067
The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity., PMID:38310100
Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats., PMID:38306928
Comparability of Elezanumab Safety, Tolerability, and Pharmacokinetics in Healthy Japanese, Chinese, and White Participants., PMID:38191982
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS., PMID:37992159
EIF4A3-regulated hsa_circ_0001445 can inhibit the progression of laryngeal squamous cell carcinoma via hsa-miR-432-5p-dependent up-regulation of RGMA expression., PMID:37902305
Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases., PMID:37439909
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion., PMID:37326791
Silencing of dentate gyrus inhibits mossy fiber sprouting and prevents epileptogenesis through NDR2 kinase in pentylenetetrazole kindling rat model of TLE., PMID:37043471
LncRNA RP11-551L14.4 suppresses breast cancer development by inhibiting the expression of miR-4472., PMID:36523479
Reduced plasma levels of RGM-A predict stroke-associated pneumonia in patients with acute ischemic stroke: A prospective clinical study., PMID:36188375
Phase 1 Evaluation of Elezanumab (Anti-Repulsive Guidance Molecule A Monoclonal Antibody) in Healthy and Multiple Sclerosis Participants., PMID:36093738
RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro., PMID:36089003
Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury., PMID:35810963
Modulation of Microglia M2 Polarization and Alleviation of Hippocampal Neuron Injury By MiR-106b-5p/RGMa in a Mouse Model of Status Epilepticus., PMID:35789312
Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice., PMID:35784362
RGMa Participates in the Blood-Brain Barrier Dysfunction Through BMP/BMPR/YAP Signaling in Multiple Sclerosis., PMID:35664003
Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus., PMID:35544694
Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D., PMID:35440409
Transcriptomic characterization of the molecular mechanisms induced by RGMa during skeletal muscle nuclei accretion and hypertrophy., PMID:35255809
Expression and Clinical Correlation Analysis Between Repulsive Guidance Molecule a and Neuromyelitis Optica Spectrum Disorders., PMID:35185873
RGMa Signal in Macrophages Induces Neutrophil-Related Astrocytopathy in NMO., PMID:35167145
RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells., PMID:35029290
A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease., PMID:34946941
Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer., PMID:34754080
Elevated RGMA Expression Predicts Poor Prognosis in Patients with Glioblastoma., PMID:34588781
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models., PMID:34478849
miR-106b-5p upregulation is associated with microglial activation and inflammation in the mouse hippocampus following status epilepticus., PMID:34476536
PPARγ-Induced Global H3K27 Acetylation Maintains Osteo/Cementogenic Abilities of Periodontal Ligament Fibroblasts., PMID:34445348
An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury., PMID:34077429
Repulsive Guidance Molecule-a and Central Nervous System Diseases., PMID:33997000
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates., PMID:33991647
For research use only. Not for human or drug use.
